Destruction of living cells by pulsed high-voltage application

Mizuno, Akira; Hori, Yasuhiko

doi:10.1109/28.2886

Cited by 176 publications

(56 citation statements)

References 4 publications

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“…The most popular theory describing PEF inactivation of microorganisms was recently reviewed by Castro et al (2) and involves pore formation and destruction of the semipermeable membrane barrier. Changes to the S. cerevisiae cells observed by scanning electron microscopy (SEM) after PEF treatment include: surface roughening and pinholes (17), craters or holes (18), elongation, roughening, wrinkling and increased bud scar formation (19). Reports of transmission electron microscopy (TEM) techniques to observe PEF treated yeast cells are not available.…”

Section: Introductionmentioning

confidence: 99%

Structural Changes Induced by Pulsed Electric Field Treatment

Harrison

Barbosa‐Cánovas

Swanson

1997

LWT - Food Science and Technology

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Section: Introductionmentioning

confidence: 99%

Structural Changes Induced by Pulsed Electric Field Treatment

Harrison

Barbosa‐Cánovas

Swanson

1997

LWT - Food Science and Technology

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“…Mizuno reported killing living cells using pulsed arc discharges (Mizuno and Hori 1988) and Laroussi (1996) reported the use of DBD to kill bacteria. Kono and Iwamoto (2004) Gliding arc 3 60 Korolev et al (2014), Wu et al (2015) NEAPP -320 Iwasaki et al (2008) LIBS 100 800 Nedanovska et al (2011) In 2006, Fridman reported replacing one of the electrodes in a DBD with a biological object with high capacitance and using it as a floating electrode, as shown in Fig.…”

Section: Plasma Sourcesmentioning

confidence: 99%

State of the art in medical applications using non-thermal atmospheric pressure plasma

Tanaka

Ishikawa

Mizuno

et al. 2017

Rev. Mod. Plasma Phys.

107

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Plasma medical science is a novel interdisciplinary field that combines studies on plasma science and medical science, with the anticipation that understanding the scientific principles governing plasma medical science will lead to innovations in the field. Non-thermal atmospheric pressure plasma has been used for medical treatments, such as for cancer, blood coagulation, and wound healing. The interactions that occur between plasma and cells/tissues have been analyzed extensively. Direct and indirect treatment of cells with plasma has broadened the applications of non-thermal atmospheric pressure plasma in medicine. Examples of indirect treatment include plasma-assisted immune-therapy and plasma-activated medium. Controlling intracellular redox balance may be key in plasma cancer treatment. Animal studies are required to test the effectiveness and safety of these treatments for future clinical applications.Keywords Plasma medical science Á Plasma cancer therapy Á Plasma-activated medium (PAM) Á Reactive oxygen species (ROS) Abbreviations ALKAnaplastic lymphoma kinase AMD Age-related macular degeneration APF Aminophenyl Fluorescein CNV

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“…Researchers have proposed other, more efficient electrode systems for PEF sterilization [22]. Ohshima et al [12] has reported that a partially concentrated PEF yields efficient PEF sterilization.…”

Section: Improvement Of Chamber Structure For Pef Sterilizationmentioning

confidence: 99%