Destruction of meningeal cells over the newborn hamster cerebellum with 6-hydroxydopamine prevents foliation and lamination in the rostral cerebellum

Doeberitz, C. von Knebel; Sievers, Jobst; Sadler, Martin; Pehlemann, F. W.; Berry, Martin; Halliwell, P.

doi:10.1016/0306-4522(86)90256-3

Cited by 57 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Dandy-Walker malformations are not always associated with congenital hydrocephalus, and these patients tend to develop hydrocephalus after birth, so that this theory seems to be far away from dealing with the exact underlying mechanism. Recent experimental studies suggest a possible modulator role of meningeal cells in the development of the cerebellum and 4th ventricle [28, 29]. Barkovich et al [5, 27, 30]hypothesized that excessive meningeal melanosis may result in defective ectodermal-mesodermal interaction causing the missed development of the cerebellum and 4th ventricle.…”

Section: Discussionmentioning

confidence: 99%

Neurocutaneous Melanosis Associated with Dandy-Walker Malformation

et al. 2000

View full text Add to dashboard Cite

Neurocutaneous melanosis is a rare dysmorphogenesis associated with single or multiple giant pigmented cutaneous nevi and diffuse involvement of the leptomeninges anywhere in the central nervous system (CNS). It is interesting that almost 8–10% of patients had associated Dandy-Walker malformation in the literature, suggesting a common origin of the developmental abnormalities. In this article, we present a 2-year-old patient with neurocutaneous melanosis associated with Dandy-Walker malformation. We reviewed the literature and discuss the pathogenesis based on the preferred hypotheses so far.

show abstract

Section: Discussionmentioning

confidence: 99%

Neurocutaneous Melanosis Associated with Dandy-Walker Malformation

et al. 2000

View full text Add to dashboard Cite

show abstract

“…A number of studies have shown that the pial BL is crucial for neocortical development. Removal of the BL leads to detachment of RGC fibers, affecting RGC survival and cortical lamination von Knebel Doeberitz et al 1986;Sievers et al 1994;Radakovits et al 2009). Laminins are major components of the BL (Timpl et al 1979) and are also present in the VZ of the developing neocortex (Campos et al 2004;Lathia et al 2007).…”

Section: Lamininsmentioning

confidence: 99%

Extracellular Matrix: Functions in the Nervous System

Barros

Franco

Müller

2010

Cold Spring Harbor Perspectives in Biology

360

274

View full text Add to dashboard Cite

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system.

show abstract

“…24 Furthermore, the authors of recent experimental studies have indicated the possibility of a modulator role for meningeal cells in the development of the cerebellum and fourth ventricle. 28,33 Barkovich and colleagues 3,4 and Kadonaga, et al, 15 have suggested that the association of neurocutaneous melanosis and Dandy-Walker malformation might be related to a generalized defect in ectodermal-mesodermal interaction based on these experimental data. Moreover, because meningeal cells are not destroyed in neurocutaneous melanosis, these authors have proposed that leptomeningeal melanosis might interfere with the normal inductive effects of primitive meningeal cells on the deposition of extracellular matrix, neuronal cell migration, and formation of normal basal CSF resorption pathways, resulting in vermian hypogenesis and retrocerebellar cyst formation.…”

Section: Discussionmentioning

confidence: 95%

Neurocutaneous melanosis associated with Dandy—Walker malformation and a meningohydroencephalocele

Arai

Nosaka²,

Kashihara³

et al. 2004

Journal of Neurosurgery: Pediatrics

View full text Add to dashboard Cite

Neurocutaneous melanosis and Dandy-Walker malformation are both forms of rare congenital neurodysplasia. Interestingly, 8 to 10% of patients with neurocutaneous melanosis also harbor an associated Dandy-Walker malformation, indicating that these developmental abnormalities share a common origin. The authors describe a case of neurocutaneous melanosis associated with Dandy-Walker malformation and an occipital meningohydroencephalocele with a giant melanotic nevus. Multiple congenital liver masses were also observed in the infant. The occipital nevus was totally excised, and ventriculoperitoneal and cyst-peritoneal shunts were created to prevent subsequent hydrocephalus. Findings in this case support the possibility that excessive melanocytes hinder normal mesenchymal development, causing Dandy-Walker malformation and an occipital meningocele.

show abstract

Destruction of meningeal cells over the newborn hamster cerebellum with 6-hydroxydopamine prevents foliation and lamination in the rostral cerebellum

Cited by 57 publications

References 33 publications

Neurocutaneous Melanosis Associated with Dandy-Walker Malformation

Neurocutaneous Melanosis Associated with Dandy-Walker Malformation

Extracellular Matrix: Functions in the Nervous System

Neurocutaneous melanosis associated with Dandy—Walker malformation and a meningohydroencephalocele

Contact Info

Product

Resources

About