2019
DOI: 10.1155/2019/8243813
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Destruction of the Dorsal Motor Nucleus of the Vagus Aggravates Inflammation and Injury from Acid-Induced Acute Esophagitis in a Rat Model

Abstract: Background/Aims. The aim of this study is to examine the protective effect of the cholinergic anti-inflammatory pathway (CAP) in experimental esophagitis in rats. Methods. A total of 40 male Sprague-Dawley (SD) rats were randomly divided into five groups as follows: control group, sham + saline group, sham + acid group, operation + saline group, and operation + acid group. Two weeks after the dorsal motor nucleus of the vagus (DMV) destruction, hydrochloric acid with pepsin was perfused into the lower part of … Show more

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Cited by 3 publications
(1 citation statement)
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“…In animal models, this deleterious effect of acid‐induced oesophageal inflammation can be ameliorated with ketotifen, a noncompetitive H1‐antihistamine and mast cell stabiliser 31 . Moreover, acid‐induced acute oesophagitis is worsened by destruction of the dorsal motor nucleus of the vagus, the efferent source of vagal tone, and in combination with our data suggest that the cholinergic anti‐inflammatory pathway may represent a therapeutic target 32 …”
Section: Discussionsupporting
confidence: 56%
“…In animal models, this deleterious effect of acid‐induced oesophageal inflammation can be ameliorated with ketotifen, a noncompetitive H1‐antihistamine and mast cell stabiliser 31 . Moreover, acid‐induced acute oesophagitis is worsened by destruction of the dorsal motor nucleus of the vagus, the efferent source of vagal tone, and in combination with our data suggest that the cholinergic anti‐inflammatory pathway may represent a therapeutic target 32 …”
Section: Discussionsupporting
confidence: 56%