Destructive Arthritis in Vaccinated Interferon Gamma-Deficient Mice Challenged withBorrelia burgdorferi: Modulation by Tumor Necrosis Factor Alpha

Abstract

We found that

Lyme Arthritis: Current Concepts and a Change in Paradigm

“…Depending upon the experimentation, however, investigators can utilize another model of Lyme arthritis. Arthritis is induced in hamsters (40,89) and mice (28,35,70,(109)(110)(111) following Borrelia-vaccination and challenge. The histopathology of the tibiotarsal joint induced in Borrelia-vaccinated and -challenged hamsters or mice is similar to the histopathology induced in Borrelia-infected mice; however, the histopathology is enhanced.…”

Expanded role for interleukin‐17 in lyme arthritis: Comment on the article by Codolo et al

“…In summary, the studies by Codolo and colleagues (1) and those using the Borrelia vaccination and challenge model of Lyme arthritis (3)(4)(5)(6)(7)(8) can be used to further explore the complex immunologic pathways responsible for the development and resolution of Lyme arthritis.…”

Reply to letter by Nardelli and Schell commenting on the pathogenesis of lyme arthritis

“…Nardelli and Schell make important points that are largely consistent with our own findings. In particular, the authors stress that Th1 cells, producing high levels of interferon-␥ [IFN␥], are not solely responsible for the induction of Lyme arthritis (3,4), since experimental Lyme arthritis can occur and propagate even in IFN␥-deficient mice (5,6). The possible involvement of interleukin-17 (IL-17) in the genesis of Lyme arthritis is suggested by the observations that IL-17 inhibition prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi (7), and that T cell priming with peptides in the presence of B burgdorferi induces IL-17 production in Th cells (8).…”