Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes

Jin, Bu; Ji, Fangfang; Zuo, Anjun; Liu, Huiting; Lin, Qingshan; He, Yun; Wang, Qingyao; Zhao, Peng

doi:10.1536/ihj.19-372

Cited by 20 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This leads to a decrease in contraction amplitude, longer time of peak and reduced synchronization. 21 Similar TMAO-induced abnormalities in contractility were also reported in ex-vivo human cardiac tissue. 22…”

Section: Direct Cardiotoxic and Proarrhythmic Effects Of Tmaosupporting

confidence: 62%

Trimethylamine N-oxide in cardiovascular disease

Konieczny¹,

Kuliczkowski²

2022

Adv Clin Exp Med

View full text Add to dashboard Cite

Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. Exploring new pathophysiological pathways enables a better understanding of CVD at both the molecular and clinical levels. Gut microbiota as a potential modulator of CVD are the subject of extensive research. In recent years, trimethylamine N-oxide (TMAO), a biologically active molecule generated by the gut microbiota, has been widely tested in studies on various populations of patients. The ultimate TMAO levels depend on individual features and gut microbiota composition. Most of the research on TMAO has focused on atherosclerotic CVD and heart failure (HF). Studies conducted so far support the use of TMAO as a prognostic marker in CVD. Several studies describe diverse interventions aimed at reducing the concentration of TMAO and its harmful effects. This article summarizes the findings from research, discusses the major insights into TMAO metabolism and related pathophysiological processes, as well as indicates the directions for future research.

show abstract

Section: Direct Cardiotoxic and Proarrhythmic Effects Of Tmaosupporting

confidence: 62%

Trimethylamine N-oxide in cardiovascular disease

Konieczny¹,

Kuliczkowski²

2022

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Savi et al found that TMAO promotes the release of calcium ions in cardiac muscle cells of healthy mice and thus alters their contractility [ 95 , 96 ]. Recently, the in-depth work carried out by Jin et al showed that TMAO confers detrimental effects on adult cardiomyocytes by inducing T-tubule network damage and Ca handling dysfunction [ 97 ]. When TMAO was administered to HF mice, Organ et al found that mouse cardiac function deteriorated significantly, characterized by pulmonary oedema, cardiac enlargement, and decreased ejection fraction [ 98 ].…”

Section: Implications Of Gut Microbiota In Cvdsmentioning

confidence: 99%

Implication of Gut Microbiota in Cardiovascular Diseases

Zhou

Cheng

Zhu

et al. 2020

Oxidative Medicine and Cellular Longevity

107

View full text Add to dashboard Cite

Emerging evidence has identified the association between gut microbiota and various diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has been described in detail in CVDs, such as hypertension, atherosclerosis, myocardial infarction, heart failure, and arrhythmia. In contrast, the importance of fermentation metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and secondary bile acid (BA), has also been implicated in CVD development, prevention, treatment, and prognosis. The potential mechanisms are conventionally thought to involve immune regulation, host energy metabolism, and oxidative stress. However, numerous types of programmed cell death, including apoptosis, autophagy, pyroptosis, ferroptosis, and clockophagy, also serve as a key link in microbiome-host cross talk. In this review, we introduced and summarized the results from recent studies dealing with the relationship between gut microbiota and cardiac disorders, highlighting the role of programmed cell death. We hope to shed light on microbiota-targeted therapeutic strategies in CVD management.

show abstract

“…TMAO has been positively correlated with enhanced atherosclerosis [74,75] and cholesterol-laden macrophage foam cell formation [76], platelet hyper-reactivity (through calcium release), and increased thrombosis potential, vascular inflammation, and inflammasome activation [77][78][79]. Consequently, numerous large-scale clinical cohorts have established the vital involvement of TMAO in many CVD phenotypes, such as coronary artery disease (CAD) [80], heart attack and ischemic stroke [81,82], heart failure [83,84], acute coronary syndrome [80], and peripheral artery disease [85]. Bile acids are also responsible for the modulation of certain diseases, as we have already discussed above.…”

Section: Gut Metabolitesmentioning

confidence: 99%

The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives

et al. 2022

View full text Add to dashboard Cite

The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen shapes our health in many ways. Structural and functional perturbations in the gut microbial pool, known as “dysbiosis”, have been proven to play a vital role in the pathophysiology of several diseases, including cardiovascular disease (CVD). Although therapeutic regimes are available to treat this group of diseases, they have long been the main cause of mortality and morbidity worldwide. While age, sex, genetics, diet, tobacco use, and alcohol consumption are major contributors (World Health Organization, 2018), they cannot explain all of the consequences of CVD. In addition to the abovementioned traditional risk factors, the constant search for novel preventative and curative tools has shed light on the involvement of gut bacteria and their metabolites in the pathogenesis of CVD. In this narrative review, we will discuss the established interconnections between the gut microbiota and CVD, as well as the plausible therapeutic perspectives.

show abstract

Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes

Cited by 20 publications

References 40 publications

Trimethylamine N-oxide in cardiovascular disease

Trimethylamine N-oxide in cardiovascular disease

Implication of Gut Microbiota in Cardiovascular Diseases

The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives

Contact Info

Product

Resources

About