Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice

Zhang, Kun; Xian, Qiming; Qiu, Juhui; Sun, Tong; Qu, Kai; Din, Ahmad Ud; Yan, Wenhua; Li, Tianhan; Chen, Yidan; Gu, Wei; Rao, Xiancai; Wang, Guixue

doi:10.1016/j.gendis.2021.09.007

Cited by 26 publications

(21 citation statements)

References 50 publications

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“…Meanwhile, the metabolite lipopolysaccharide synthesized by Desulfovibrio of the Proteobacteria phylum is a potential causative factor for inflammatory diseases of the gastrointestinal tract [47]. It could be speculated that Met and TGP improve insulin resistance and reduce FBG levels in diabetic mice by reducing the relative abundance of norank_f_Lachnospiraceae and Desulfovibrio.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Jiang¹,

Chen²,

Wang³

et al. 2024

Food Science and Human Wellness

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Type 2 diabetes mellitus (T2DM) is a complex metabolic disease threatening human health. We investigated the effects of Tegillarca granosa polysaccharide (TGP) and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin. TGP (5.1×10 3 Da) was composed of mannose, glucosamine, rhamnose, glucuronic acid, galactosamine, glucose, galactose, xylose, and fucose. It could significantly alleviate weight loss, reduce fasting blood glucose levels, reverse dyslipidemia, reduce liver damage from oxidative stress, and improve insulin sensitivity. RT-PCR and western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance. TGP increased the abundance of Allobaculum, Akkermansia, and Bifidobacterium, restored the microbiota abundance in the intestinal tracts of mice with T2DM, and promoted short-chain fatty acid production. This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Jiang¹,

Chen²,

Wang³

et al. 2024

Food Science and Human Wellness

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“…[ 39 ] Orally gavaged of A. muciniphila inhibits AS by protecting the gut barrier and alleviating metabolic endotoxemia‐induced inflammation. [ 7 ] Additionally, it increased the thickness of the intestinal mucosal layer and goblet cell numbers. [ 7 ] Goblet cells synthesize and secrete mucins to form a mucosal barrier and prevent bacteria from contacting the intestinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Additionally, it increased the thickness of the intestinal mucosal layer and goblet cell numbers. [ 7 ] Goblet cells synthesize and secrete mucins to form a mucosal barrier and prevent bacteria from contacting the intestinal epithelium. [ 40 ] CMOS intervention (400–1200 mg kg −1 ·bw d −1 ) improved the expression of tight junction proteins and recovered the goblet cell number (Figures 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

“…[9,10] Probiotic strain Akkermansia muciniphila attenuates atherosclerotic lesions by ameliorating inflammation and intestinal barrier damage induced by metabolic endotoxemia. [7] Metformin effectively suppresses the atherosclerotic process by altering the gut microbiota and increasing intestinal permeability. [11] These results suggest that AS can be mitigated through the modulation of gut microbiotainduced inflammation and the restoration of intestinal barrier dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…[5] Numerous studies have demonstrated that the intestinal permeability in atherosclerotic mice is upregulated by increased intestinal inflammation. [6][7][8] Moreover, an unbalanced intestinal microbiota can induce gut inflammation and can damage the integrity of the gut barrier. [9,10] Probiotic strain Akkermansia muciniphila attenuates atherosclerotic lesions by ameliorating inflammation and intestinal barrier damage induced by metabolic endotoxemia.…”

Section: Introductionmentioning

confidence: 99%

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Manno‐oligosaccharides from Cassia Seed Gum Attenuate Atherosclerosis through Inflammation Modulation and Intestinal Barrier Integrity Improvement in ApoE^−/− Mice

Li,

Zhen,

Yang

et al. 2023

Molecular Nutrition Food Res

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ScopeManno‐oligosaccharides from cassia seed gum (CMOS) have demonstrated anti‐inflammatory and regulatory effects on cholesterol metabolism. However, their protective effects against the progression of atherosclerosis (AS) and underlying molecular mechanisms have not been investigated. This study investigates the anti‐atherosclerotic effects of CMOS on ApoE−/− mice.Methods and resultsCMOS are supplemented in atherosclerotic male ApoE−/− mice fed with a high‐fat‐high‐cholesterol diet (HFHCD). After the 12‐week intervention, CMOS at 1200 mg kg−1·bw d−1 significantly decrease the atherosclerotic lesion area by 0.63‐fold and the aortic arch lesion size by 0.63‐fold when compared to the HFHCD group. Moreover, inflammation in atherosclerotic lesions is reduced by CMOS intervention, and the levels of serum lipids and inflammatory cytokines are decreased. The number of goblet cells and the expression of intestinal epithelial tight junction proteins in the H‐CMOS group increase, thus indicating that CMOS can restore intestinal barrier integrity in atherosclerotic mice. Furthermore, CMOS reshape the unbalanced gut microbiota in ApoE−/− mice caused by HFHCD, and reduce the relative abundance of Desulfovibrio and Faecalibaculum that exhibits positive relationships with inflammation.ConclusionCMOS inhibit inflammation, alter intestinal barrier integrity, and regulate gut microbiota to attenuate AS in ApoE−/− mice.

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Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism

Hassan,

Luqman,

Zhang

et al. 2024

World J Microbiol Biotechnol

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Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice

Cited by 26 publications

References 50 publications

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Manno‐oligosaccharides from Cassia Seed Gum Attenuate Atherosclerosis through Inflammation Modulation and Intestinal Barrier Integrity Improvement in ApoE^−/− Mice

Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism

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Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice

Cited by 26 publications

References 50 publications

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Manno‐oligosaccharides from Cassia Seed Gum Attenuate Atherosclerosis through Inflammation Modulation and Intestinal Barrier Integrity Improvement in ApoE−/− Mice

Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism

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Product

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Manno‐oligosaccharides from Cassia Seed Gum Attenuate Atherosclerosis through Inflammation Modulation and Intestinal Barrier Integrity Improvement in ApoE^−/− Mice