2024
DOI: 10.1002/anie.202407114
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Desymmetrization of Cyclic Sulfonimidamides by Asymmetric Allylation

David A. Gutierrez,
Garrett Toth‐Williams,
Croix J. Laconsay
et al.

Abstract: Herein we report the first transition metal‐catalyzed approach to the enantioenriched synthesis of cyclic sulfonimidamides relying on commercially available palladium catalysts and ligands. High‐throughput experimentation (HTE) was employed to identify the optimal catalyst system and solvent.  The method is applied to a variety of saturated and unsaturated rings and exhibits the highest selectivity for 2‐substituted allyl electrophiles. The products are further elaborated to complex, tricyclic scaffolds. DFT e… Show more

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