Detachable Dissolvable Microneedles: Intra-epidermal and Intradermal Diffusion, Effect on Skin Surface, and Application in Hyperpigmentation Treatment

Sawutdeechaikul, Pritsana; Kanokrungsee, Silada; Sahaspot, Thanyapat; Thadvibun, Kamonwan; Banlunara, Wijit; Limcharoen, Benchaphorn; Sansureerungsikul, Titiporn; Rutwaree, Teeranut; Oungeun, Miranda; Wanichwecharungruang, Supason

doi:10.21203/rs.3.rs-860932/v1

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…The mechanical force of the MN patch required for penetration is notably similar to that required for pressing a microneedle into healthy skin. [29] In essence, our microneedle patch system meets the requirements of the intended application.…”

Section: Preparation and Characterization Of Anti-pbp2a And W379 Co-l...mentioning

confidence: 99%

It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms

Su,

Shahriar,

Andrabi

et al. 2024

Macromolecular Bioscience

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Wound biofilms pose a great clinical challenge. Herein, we report a dissolvable microneedle patch for dual delivery of monoclonal antibodies anti‐PBP2a and engineered antimicrobial peptides W379. in vitro antibacterial efficacy testing with microneedle patches containing a combination of 250 ng/mL W379 and 250 ng/mL anti‐BPB2a decreased the bacterial count from ∼3.31 × 107 CFU/mL to 1.28 × 102 CFU/mL within 2 h without eliciting evident cytotoxicity. ex vivo testing indicates W379 and anti‐PBP2a co‐loaded microneedle patch displayed a remarkable reduction of bacterial load by approximately 7.18 log CFU after administered only once within 48 h. The bacterial count was significantly diminished compared to the treatment by either W379 or anti‐PBP2a‐loaded alone microneedle patches. When administered twice within 48 h, no bacteria were identified. Further in vivo study also revealed that after two treatments of W379 and anti‐PBP2a co‐loaded PVP microneedle patches within 48 h, the bacterial colonies were undetectable in a type II diabetic mouse wound biofilm model. Taken together, W379 and anti‐PBP2a co‐loaded PVP microneedle patches hold great promise in treating wound biofilms.This article is protected by copyright. All rights reserved

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Section: Preparation and Characterization Of Anti-pbp2a And W379 Co-l...mentioning

confidence: 99%

It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms

Su,

Shahriar,

Andrabi

et al. 2024

Macromolecular Bioscience

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Section: μNds Design Distinctions For Pre-clinical and Clinical Testingmentioning

confidence: 99%

“…The immune rich nature of the skin makes it a highly responsive organ towards the μND delivery of any therapeutic medication [64,65]. As a result, mild and temporary erythema may develop as a potential side effect depending on the size and type of the administered medication [64,65]. Therefore, skin irritation, sensitisation, and immune response must be evaluated as part of the safety assessment protocols of μND products during clinical trials.…”

Section: μNds Design Distinctions For Pre-clinical and Clinical Testingmentioning

confidence: 99%

Skin biomechanics: Breaking the dermal barriers with microneedles

et al. 2022

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Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review, we discuss both the anatomical features and biomechanical properties of skin in order to understand the local environment and resistive forces relevant to μNDs insertion. Of particular importance are the factors that affect μND insertion, such as their geometry and material composition, as these can be manipulated in the design and development phase to optimise skin insertion. We review the research relevant to μND and how this interacts with skin properties. We have also reviewed the most commonly used skin drug diffusion modelling used to predict drug behaviour from μNDs, and discussed the current challenges faced by μNDs to enter clinical trials and provide positive clinical outcomes.

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“…Nowadays, there are different types of microneedles available for drug delivery, including solid, coated, dissolving, hollow, and hydrogel microneedles [10]. Recently, detachable dissolvable microneedles, microneedles that can detach from the base and be deposited into the skin during the short application time, have also been introduced [13,14].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Detachable Microneedle Patch Containing Triamcinolone Acetonide in the Treatment of Inflammatory Acne

Thantaviriya

Rojhirunsakool

Kamanamool

et al. 2022

Preprint

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Detachable microneedles (DMNs) are dissolvable microneedles that detach from the base during administration. The use of DMNs-containing steroids for acne has never been investigated. Thirty-five patients with facial inflammatory acne were evaluated for acne treatment efficacy and safety of DMNs and DMNs containing triamcinolone acetonide (TA) via a 28-day randomized, double-blind, controlled trial. Four inflammatory acne lesions were selected from each participant and randomly treated with a single application of 700 µm DMNs containing 262.02 ± 15.62 µg TA (700DMNTA), 1000 µm DMNs containing 160.00 ± 34.92 µg TA (1000DMNTA), 700 µm DMN without TA (700DMN), and a control. Efficacy was measured by assessing physical grading, diameter, volume, erythema index, and melanin index. Safety was evaluated by assessing reports of adverse effects from patients and physicians. All three treatment groups achieved resolution of inflammatory acne significantly faster than the control group, with median times for resolution of 4.6, 5.25, 6.7, and 8.1 days in the 1000DMNTA, 700DMNTA, 700DMN, and control, respectively. When compared to the control group, the diameters and post-acne erythema of inflammatory acne were significantly reduced in the treatment groups. The 1000DMNTA decreased acne size and erythema more than other treatments. DMNTA also tended to decrease acne size and erythema more than DMN with no TA, but there was no statistically significant difference. All participants preferred DMN over conventional intralesional steroid injection due to less pain and self-application. No adverse effect was observed. DMNTA is a safe, effective alternative treatment for inflammatory acne that significantly reduces post-acne erythema. Trial registration: TCTR20211215006 on December 15, 2021

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Detachable Dissolvable Microneedles: Intra-epidermal and Intradermal Diffusion, Effect on Skin Surface, and Application in Hyperpigmentation Treatment

Cited by 3 publications

References 36 publications

It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms

It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms

Skin biomechanics: Breaking the dermal barriers with microneedles

Efficacy and Safety of Detachable Microneedle Patch Containing Triamcinolone Acetonide in the Treatment of Inflammatory Acne

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