Detailed characterization of an injectable hyaluronic acid-polyaspartylhydrazide hydrogel for protein delivery

Zhang, Rui; Huang, ZhiBing; Xue, Mingyuan; Yang, Jing; Tan, Tianwei

doi:10.1016/j.carbpol.2011.02.014

Cited by 34 publications

(19 citation statements)

References 37 publications

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“…HA-based injectable hydrogels formed via hydrazone chemistry have been demonstrated by the Tan group to be effective for sitespecifi c protein delivery while eliciting low cellular toxicity. [ 170 ] Kohane and co-workers have demonstrated the high tolerability of hydrazone-cross-linked hydrogels prepared based on a variety of carbohydrates in the peritoneum, a typically particularly challenging biological environment for biomaterial use. [ 15 ] Varghese and co-workers [ 171 ] demonstrated the effective use of hydrazone-cross-linked HA-based hydrogels to deliver a growth factor used in spinal fusion and promote simultaneous angiogenesis.…”

Section: Cross-linking Via Hydrazone Bond Formationmentioning

confidence: 99%

Designing Injectable, Covalently Cross‐Linked Hydrogels for Biomedical Applications

Patenaude

Smeets

Hoare

2014

Macromol. Rapid Commun.

165

125

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Hydrogels that can form spontaneously via covalent bond formation upon injection in vivo have recently attracted significant attention for their potential to address a variety of biomedical challenges. This review discusses the design rules for the effective engineering of such materials, and the major chemistries used to form injectable, in situ gelling hydrogels in the context of these design guidelines are outlined (with examples). Directions for future research in the area are addressed, noting the outstanding challenges associated with the use of this class of hydrogels in vivo.

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Section: Cross-linking Via Hydrazone Bond Formationmentioning

confidence: 99%

Designing Injectable, Covalently Cross‐Linked Hydrogels for Biomedical Applications

Patenaude

Smeets

Hoare

2014

Macromol. Rapid Commun.

165

125

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“…However, they do not dissolve in water when brought into contact with water (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009). The water holding capacity of hydrogels is induced by the presence of hydrophilic groups, such as hydroxyl, carboxyl, amide, and sulfonic groups distributed along the backbone of polymer chain; whereas the cross-links are formed by either covalent bonds, electrostatic or dipole-dipole interactions (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009.Hydrogels have achieved considerable interest in the last few decades due to their wide range of clinical and biomedical applications ranging from drug delivery (Qui and Park, 2001), tissue engineering (El-Sherbiny and Yacoub, 2013;Vlierberghe, 2011&Hoffman, 2002,regenerative medicine (El-Sherbiny and Yacoub, 2013), contact lenses (Walther, 2011& Zhang, 2011), wound dressings (El-Kased, 2017Gupta, 2011& Lu, 2010, soil water retention (Wei and Durian, 2013) to disposable diapers (Colón, 2011).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Xanthan gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Evaluating Skin Wound Healing Efficacy

Shawan¹,

Islam²,

Aziz³

et al. 2019

MAS

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With the background of snowballing threat of skin wound to public health and economy, this study was undertaken utilizing xanthan gum (Xnt), citric acid (C), gelatin (Gel), glutaraldehyde (G) and HPLC-grade water to fabricate a series of composite hydrogels i.e. experimental rat skin wound model. Physicochemical characterization revealed that all the composite hydrogels contained more than 90% water. The hydrogels displayed swelling ability, biodegradability, good polymeric networks and porosity. Fourier Transform Infrared Spectroscopy (FT-IR) studies confirmed the presence of bound water and free, intra and inter molecular bound hydrogen bonded OH and NH in the hydrogels. All the hydrogels showed significant wound healing potency in experimental deep second degree skin burns in rats compared to controls.

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“…However, studies have demonstrated that these kinds of hydrogels show low mechanical capacity and structural stability. Recently, chemically cross‐linked injectable hydrogels formed by in situ formation of chemical bonds under physiological conditions through mixing two functional polymers have attracted more attention for their good stability and functionality . For example, Weng et al has prepared a series of in situ gelable hydrogels from oxidized dextran and N ‐carboxyethyl chitosan based on Schiff base without any extraneous cross‐linking agent.…”

Section: Introductionmentioning

confidence: 99%

“…These preparation approaches always involve toxic reagents and limit their biomedical applications. Several semi‐synthetic hydrogels were prepared by combined natural polymer with PAsp derivatives, especially polyaspartyl hydrazide (PAHy) . Zhang et al prepared an injectable hyaluronic acid (HA)‐PAHy hydrogel for protein delivery.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, chemically cross-linked injectable hydrogels formed by in situ formation of chemical bonds under physiological conditions through mixing two functional polymers have attracted more attention for their good stability and functionality. [14][15][16][17][18] For example, Weng et al 16 has prepared a series of in situ gelable hydrogels from oxidized dextran and N-carboxyethyl chitosan based on Schiff base without any extraneous cross-linking agent. In this system, both dextran and chitosan are natural polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

Wang

et al. 2013

J Biomedical Materials Res

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An injectable hydrogel via hydrazone cross-linking was prepared under mild conditions without addition of cross-linker or catalyst. Hydrazine and aldehyde modified poly(aspartic acid)s were used as two gel precursors. Both of them are water-soluble and biodegradable polymers with a protein-like structure, and obtained by aminolysis reaction of polysuccinimide. The latter can be prepared by thermal polycondensation of aspartic acid. Hydrogels were prepared in PBS solution and characterized by different methods including gel content and swelling, Fourier transformed-infrared spectroscopy, and in vitro degradation experiment. A scanning electron microscope viewed the interior morphology of the obtained hydrogels, which showed porous three-dimensional structures. Different porous sizes were present, which could be well controlled by the degree of aldehyde substitution in precursor poly(aspartic acid) derivatives. The doxorubicin-loaded hydrogels were prepared and showed a pH-sensitive release profile. The release rate can be accelerated by decreasing the environmental pH from a physiological to a weak acidic condition. Moreover, the cell adhesion and growth behaviors on the hydrogel were studied and the polymeric hydrogel showed good biocompatibility.

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Detailed characterization of an injectable hyaluronic acid-polyaspartylhydrazide hydrogel for protein delivery

Cited by 34 publications

References 37 publications

Designing Injectable, Covalently Cross‐Linked Hydrogels for Biomedical Applications

Designing Injectable, Covalently Cross‐Linked Hydrogels for Biomedical Applications

Fabrication of Xanthan gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Evaluating Skin Wound Healing Efficacy

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

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