Detailed droplet routing and complexity characterization on a digital microfluidic biochip

L'Orsa, Rachael; Bhattacharjee, Biddut; Hoorfar, Mina; Holzman, Jonathan F.; Najjaran, Homayoun

doi:10.1117/12.819356

Cited by 2 publications

(1 citation statement)

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“…A typical compilation sequence is shown in Figure 3. The DAG is first scheduled [Ding et al 2001;Ricketts et al 2006;Su and Chakrabarty 2008;Grissom and Brisk 2012b;O'Neal et al 2012]; dimensions for each operational module are selected [Su and Chakrabarty 2005;; scheduled operations are then placed onto the 2D grid, ensuring that no concurrently executing operations overlap to prevent interference [Su and Chakrabarty 2006b;Yuh et al 2007;Liao and Hu 2011]; lastly, non-interfering droplet routes are computed to deliver droplets to the appropriate DMFB locations at appropriate times [Su et al 2006;Bohringer 2006;Cho and Pan 2008;Yuh et al 2008;Huang and Ho 2009;L'Orsa et al 2009;Roy et al 2010Roy et al , 2012Singha et al 2010], in some cases, all of these problems can be solved in conjunction with one another .…”

Section: High-level Synthesis Backgroundmentioning

confidence: 99%

Interpreting Assays with Control Flow on Digital Microfluidic Biochips

Grissom

Curtis

Brisk

2014

J. Emerg. Technol. Comput. Syst.

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BioCoder is a C++ library developed at Microsoft Research, India, for the unambiguous specification of biochemical assays. This article describes language extensions to BioCoder along with a compiler and runtime system that translate and execute assays specified using BioCoder on a software simulator. The simulator mimics the behavior of laboratories-on-a-chip (LoCs) based on a droplet actuation technology called electrowetting on dielectric (EWoD). To date, prior compilers targeting similar EWoD devices are limited to assays specified as directed acyclic graphs (DAGs) and cannot handle arbitrary control flow or feedback from the LoC. The framework presented herein addresses these challenges through dynamic interpretation, thereby enlarging the space of assays that can be compiled onto EWoD devices.

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