Detailed exploration of pathophysiology involving inflammatory status and bleeding symptoms between lipopolysaccharide- and tissue factor-induced disseminated intravascular coagulation in rats

Suga, Yukio; Kubo, Anna; Katsura, Hideyuki; Staub, Yukiko; Tashiro, Kiyomichi; Yamada, Shinya; Morishita, Eriko; Asakura, Hitoshi

doi:10.1007/s12185-021-03158-y

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Different disease-inducing stimuli have been studied in animal models of DIC. However, with comparable coagulation activation, very different patterns of responses have been described for fibrinolytic activity, organ dysfunction, inflammation status, and bleeding symptom, which differed markedly, e.g., between endotoxin- and tissue factor-induced DIC models in rats [ 39 ]. Therefore, a careful characterization of the model is required for an experimental and clinical use of such data, which are mentioned here as examples.…”

Section: Diagnosis and Management Of Sepsis-induced Coagulopathymentioning

confidence: 99%

Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy

Wiedermann

2022

IJMS

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Recent research has contributed significantly to our understanding of the pathogenesis of acute disseminated intravascular coagulation. COVID-19 can be considered as a new underlying condition of disseminated intravascular coagulation. In this narrative review, current evidence is presented regarding biomarker differences between sepsis-induced and COVID-19-associated coagulopathies, supporting the importance of acquired antithrombin deficiency in the early differential diagnosis of septic coagulopathy and its potential impact on treatment with endogenous anticoagulants. Establishing new scoring systems for septic coagulopathy in combination with endogenous anticoagulant biomarker activities may allow for the identification of those in the heterogeneous population of sepsis patients who are more likely to benefit from targeted specific treatment interventions.

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Section: Diagnosis and Management Of Sepsis-induced Coagulopathymentioning

confidence: 99%