Detailed Histopathological Study of Endometrial Carcinoma, and Importance of Immunohistochemistry

Modi, Manisha P; Nilkanthe, Ramrao; Trivedi, Manasi

doi:10.1093/ajcp/aqw162.012

Cited by 3 publications

(3 citation statements)

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“…Modi et al in their study reported most common endometrial carcinoma were well differentiated adenocarcinoma (41%), followed by moderately differentiated adenocarcinoma (27%) and then poorly differentiated adenocarcinoma (10%). [22] Similar patterns were also observed in our study also.…”

Section: Discussionsupporting

confidence: 91%

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Bhattacharya

Jha²,

Agarwal³

et al. 2018

APALM

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Background: Endometrial lesions are represented by a set of diversified disorders which has challenged clinicians for a long time. Due to its chances of progressing to malignant states, the condition needs prompt and focussed study, keeping clinical context in view. Methods: This 12-month (June 2016-May 2017) cross-sectional studyinvolved 100 specimens from dilatation and curettage (D & C) and hysterectomy specimens from female patientsaged ≥ 18 years who presented with complain of pelvic pain, abnormal uterine bleeding, dysmenorrhoea, pelvic mass and infertility. For all the specimens received,histopathological and immunohistochemical assessment was done. Results: Out of 100 cases of abnormal uterine bleeding 44 females showed physiological changes, 25 females showed benign lesions and 20 females had malignant lesions of endometrium. Out of 20 cases of endometrial carcinoma 50 % were well differentiated and 25% were moderately differentiated and 25% were poorly differentiated. Expression of Ki-67 was >35% in poorly differentiated carcinoma. Well differentiated carcinoma showed 80-85% positivity of ER, moderately differentiated showed 30-35% positivity and poorly differentiated carcinoma showed 6-12%. The association between benign and malignant endometrial lesion was found to be statistically significant with age-group, history of contraceptive use and chronic illnesses (p<0.05). Conclusion: Endometrial biopsy is one of the prompt tools in diagnosis and assessment of the benign and malignant diseases of endometrium. Immunohistochemical markers like ER (hormonal receptor) and Ki-67 (proliferative marker) play a major role in diagnosis, prognostication and therapeutic management of malignant cases.

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Section: Discussionsupporting

confidence: 91%

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Bhattacharya

Jha²,

Agarwal³

et al. 2018

APALM

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“…In a study conducted by Modi et al most cases of endometrial carcinoma were well differentiated adenocarcinoma (41%), followed by moderately differentiated (27%) and then poorly differentiated (10%). [6] In our study most of the cases were moderately and poorly differentiated may be that patients in our case mostly report late because of illiteracy especially in rural population.…”

Section: Discussionsupporting

confidence: 47%

Expression Of Androgen Receptor, Estrogen Receptor And Progesterone Receptor In Endometrial Carcinoma (Immunohistochemical Study)

Mangal

Sharma

Manjari

et al. 2020

APALM

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Background: Endometrial carcinoma is the most common pelvic genital malignancy and 4th most frequently diagnosed cancer in females with it's incidence being 4.3/ 1 lac females.Methods: Thirty histologically proven cases of endometrial carcinoma were taken up for the study in pathology department. Immunohistochemistry for expression of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR)was done using Biocare system kit.Results: 80% of the cases were in 5th and 6th decade of life. Bleeding per vagina and post menopausal bleeding were the main complaints. Out of the total 22 abdominal hysterectomies the size of tumor varied from 1cm to >4cm. All were adenocarcinoma with 20 being moderately differentiated and only 2 being well differentiated.AR was positive in 8 cases with ER and PRbeing positive in 16 and 21 cases respectively with score being also the same. Receptor positivity decreased with increasing grade of the tumor. Conclusion:ER and PR status are important prognostic biomarkers which also predict response to antihormonal therapy in endometrial carcinoma. AR expression though associated with low grade tumors , but still is a driver for tumor growth and therefore a potential therapeautic target. Anti androgen therapy -enzalutamide may inhibit proliferation of AR positive primary endometrial cancer cells.

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“…The difference could be attributed to an overall smaller number of cases of ovarian carcinoma. Endometrial malignancies presented relatively earlier in 62% in stage I [15,16] . An interesting aspect observed was that in all the different types of malignancies the commonest age group was 51-60 years, and the commonest presenting feature was postmenopausal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Gynaecologic malignancies in women of Andaman and Nicobar islands: An insight

Sahoo¹,

Malhotra²,

Malakar³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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The rural areas of India have been under reached with respect to the gynaecologic malignancies with no previous documented studies among the tribals. The Islands of Andaman and Nicobar are home to 62% rural female population. In this study it is proposed to find the approximate incidence, evaluate the sociodemographic and clinicopathologic features associated with gynaecologic malignancies. A retrospective analysis filtering all the cases for the islands was conducted at this Secondary level care Hospital between May 2015 and April 2018. Descriptive statistics and Z test were used for statistical analysis. There were 102 newly detected cases of gynaecologic malignancies during the study period of 3 years. The approximate annual incidence of gynaecologic cancers in these Islands was around 17.29 per 100,000 and age-adjusted incidence for carcinoma cervix was around 13.62 per 100,000. Cervical cancer was the commonest type 59%. Ovarian cancer had predominance in the tribal groups (61%).

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Detailed Histopathological Study of Endometrial Carcinoma, and Importance of Immunohistochemistry

Cited by 3 publications

References 0 publications

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Histopathological and Immunohistochemical Study of Endometrial Lesions Obtained from D&C and Hysterectomy Specimens at a Tertiary Care Hospital

Expression Of Androgen Receptor, Estrogen Receptor And Progesterone Receptor In Endometrial Carcinoma (Immunohistochemical Study)

Gynaecologic malignancies in women of Andaman and Nicobar islands: An insight

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