Detailed projection patterns of septal and diagonal band efferents to the hippocampus in the rat with emphasis on innervation of CA1 and dentate gyrus

Nyakas, Csaba; Luiten, P.G.M.; Spencer, David; Traber, J.

doi:10.1016/0361-9230(87)90117-1

Cited by 194 publications

(106 citation statements)

References 46 publications

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“…One of the main questions of the present investigation was the effect of high age on 5-HT 1A receptor expression in the areas of cell groups of the cholinergic basal forebrain that are the origin of the cholinergic innervation of cortex and hippocampus (Mesulam et al, 1983;Luiten et al, 1987;Nyakas et al, 1987;Gaykema et al, 1990). A large reduction of [ 3 H]8-OH-DPAT binding was found in all four areas explored: MS, VDB and HDB and the MNB-SI (Fig.…”

Section: Discussionmentioning

confidence: 78%

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

Nyakas

Oosterink

Keijser

et al. 1997

Journal of Chemical Neuroanatomy

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Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging Nyakas, C; Oosterink, BJ; Felszeghy, K; deJong, GI; Korf, J; Luiten, PGM; Keijser, Jan N. Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Nyakas, C., Oosterink, BJ., Felszeghy, K., deJong, GI., Korf, J., Luiten, PGM., & Keijser, J. N. (1997). Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of Chemical Neuroanatomy, 13(1), 53-61. https://doi.org/10.1016/S0891-0618(97)00025-2 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractThe effect of aging on 5-HT 1A receptor binding in several forebrain areas associated with the basal forebrain cholinergic system was investigated in rats of 3-, 24-and 30-months-old by receptor autoradiography and biochemical binding assay using [ 3 H]8-OH-DPAT as a ligand. Autoradiographic measurements demonstrated a marked region-specific decline of ligand binding in: (i) regions of the basal forebrain cholinergic cell groups, i.e. the medial septum, diagonal band nuclei and magnocellular nucleus basalis, (ii) the frontal and parietal neocortex and (iii) the dentate gyrus of the hippocampus. No change or only a slight decrease of the 5-HT 1A receptor density was found in other areas investigated: the CA1 and CA3 sectors of hippocampus, the cingular and perirhinal cerebral cortex and the lateral septum. The autoradiographic findings were substantiated by the biochemical binding assay, which revealed a comparable loss of 5-HT 1A receptor in the hippocampus and neocortex at the age of 30 months. The results clearly show that with increasing age the decrement of 5-HT 1A receptor binding in the rat forebrain is remarkably region-selective and particularly affects the cholinergic cell groups that innervate cortex and hippocampus. This phenomenon appears to be especially significant in relation to the neuronal substrates underlying the age-related alterations of mood and cognition. © 1997 Elsevier Science B.V.

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Section: Discussionmentioning

confidence: 78%

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

Nyakas

Oosterink

Keijser

et al. 1997

Journal of Chemical Neuroanatomy

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“…In LM11A-31-treated samples, the numbers of BrdU cells are significantly increased, while the percentage of cells that are also NeuN1 is significantly less than in the sham-vehicle group, although resulting in numbers of double-labeled cells greater than sham and more than twofold higher than that seen in injury/vehicle. n 5 4/group; *, p < .05; **, p < .01; and ***, expressing fibers (likely type II cholinergic fibers derived from neurons in the medial septal nuclei of the basal forebrain [49,56,57]). In addition, this cell population exhibits neurotrophic responses to cholinergic activity [49].…”

Section: Discussionmentioning

confidence: 99%

A small molecule p75NTR ligand protects neurogenesis after traumatic brain injury

2013

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The p75 neurotrophin receptor (p75 NTR ) influences the proliferation, survival, and differentiation of neuronal precursors and its expression is induced in injured brain, where it regulates cell survival. Here, we test the hypotheses that pharmacologic modulation of p75 NTR signaling will promote neural progenitor survival and proliferation, and improve outcomes of traumatic brain injury (TBI). LM11A-31, an orally available, blood-brain barrier-permeant small-molecule p75 NTR signaling modulator, significantly increased proliferation and survival, and decreased JNK phosphorylation, in hippocampal neural stem/progenitor cells in culture expressing wild-type p75 NTR , but had no effect on cells expressing a mutant neurotrophinunresponsive form of the receptor. The compound also enhanced the production of mature neurons from adult hippocampal neural progenitors in vitro. In vivo, intranasal administration of LM11A-31 decreased postinjury hippocampal and cortical neuronal death, neural progenitor cell death, gliogenesis, and microglial activation, and enhanced long-term hippocampal neurogenesis and reversed spatial memory impairments. LM11A-31 diminished the postinjury increase of SOX2-expressing early progenitor cells, but protected and increased the proliferation of endogenous polysialylated-neural cell adhesion molecule positive intermediate progenitors, and restored the long-term production of mature granule neurons. These findings suggest that modulation of p75 NTR actions using small molecules such as LM11A-31 may constitute a potent therapeutic strategy for TBI. STEM CELLS

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“…This apparent paradox may be accounted for partly by anatomical differences between the two regions, including density of septohippocampal input (35)(36)(37)(38) and neurotransmitter receptor distribution (39)(40)(41)(42). Functional differences between CA3 and CA1 may also contribute, including position within the primary hippocampal trisynaptic circuit, different requirements for plastic changes in the two regions (43,44), and the greater influence of septohippocampal cholinergic input on neuronal activity in CA3 (45,46).…”

Section: Discussionmentioning

confidence: 99%

Protein kinase C redistribution within CA3 stratum oriens during acquisition of nictitating membrane conditioning in the rabbit.

Scharenberg

Olds

Schreurs

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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This manuscript describes experiments designed to investigate protein kinase C redistribution occurring during acquisition of the rabbit nictitating membrane (NM) conditioned response (CR). The first experiment defined the acquisition phase of the NM response for our laboratory. A group of rabbits (n = 6) was given 2 days of paired NM training; a second group (n = 6) was given 2 days of unpaired NM training. The data document a variable level of responding on day 1 for rabbits given paired training (mean ± SEM, 21 ± 11% CRs) but show that on day 2 most rabbits reached the behavioral asymptote (five of six rabbits responding with >85% CRs). Rabbits responding at the behavioral asymptote were defined as having acquired the NM conditioned response. These data were interpreted to indicate that 1 day of training initiated processes necessary for behavioral acquisition (i.e., responding at the behavioral asymptote). A quantitative finm autoradiographic study of [3H]phorbol 12,13-dibutyrate binding was then used to determine the distribution of hippocampal protein kinase C in rabbits sacrificed after receiving either 1 day ofpaired stimuli (n = 10), 1 day of unpaired stimuli (n = 6), or no stimuli (n = 6). Autoradiograms were analyzed by measuring binding in strictly defined regions of interest and from transept profiles. A significant increase in binding of the phorbol ester was found in the CA3 stratum oriens in the paired group relative to unpaired and naive controls. No other significant differences were found.The nictitating membrane (NM) conditioned response (CR) is an associative learning model in which rabbits learn to associate a tone (conditioned stimulus, CS) with a shock (unconditioned stimulus, US) to the periorbital region (1, 2). Retraction of the NM in response to the tone (a CR) is used to index the progression of learning. The hippocampus has been shown to be necessary for both proper consolidation of the NM response in undertrained rabbits and proper extinction of the response in overtrained rabbits (3, 4). Firing patterns for CA1 and CA3 pyramidal cells formed a striking "neural model" of the CR during paired NM training (5). Furthermore, changes in neuronal firing within the CA1 and CA3 areas of the hippocampus occurred within the first 10 paired trials and increased throughout the training period (5, 6).Extensive studies of hippocampal neurons have been performed with rabbits that were overtrained using this paradigm and sacrificed 24 hr later. In such rabbits, postsynaptic biophysical changes in CA1 neurons were demonstrated, including increased input resistance (7), decreased after hyperpolarizations (8, 9), and increased summation of postsynaptic potentials (10). Accompanying the biophysical changes at this time point were biochemical changes (11-13), with two studies localizing an increase in membrane-bound protein kinase C (mPKC) to the CAl region (11, 12). Binding of phorbol 12,13-dibutyrate (PBt2) in brain of overtrained rabbits sacrificed 72 hr after completion of training showed P...

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Detailed projection patterns of septal and diagonal band efferents to the hippocampus in the rat with emphasis on innervation of CA1 and dentate gyrus

Cited by 194 publications

References 46 publications

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

A small molecule p75NTR ligand protects neurogenesis after traumatic brain injury

Protein kinase C redistribution within CA3 stratum oriens during acquisition of nictitating membrane conditioning in the rabbit.

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