Detailed structural assessment of healthy interventricular septum in the presence of remodeling infarct in the free wall – A finite element model

Abstract

Purpose Computational modelling may improve the fundamental understanding of various mechanisms of diseases more particularly related to clinical challenges. In this study the effect of remodeling infarct presence in the left ventricle on the interventricular septal wall is studied using the finite element methods. Methods In this study, two rat heart (one model with healthy myocardium and one model with remodeling free wall and healthy septal wall) with magnetic resonance imaging data was gathered to reconstruct three-dimensional (3D) rat heart models. 3D data points from Segment® were imported into SolidEdge® for creation of 3D rat heart models. Abaqus® was used for finite element modeling. Results The strain in the healthy interventricular septum of the infarcted left ventricle wall increased when compared to the healthy interventricular septum in the healthy left ventricle. Similarly, the average stress in the healthy left ventricle was observed to have increased on the healthy the interventricular septum where the free wall is subjected to remodeling infarct. When comparing the infarcted models to the healthy model, it was found that the average strain had greatly increased by up to 50.0 %. Conclusions The remodeling infarct in the left ventricle has an impact on the healthy interventricular septal wall. Even though the interventricular septal wall was modelled as healthy, it was observed that it has undergone considerable changes in stresses and strains in circumferential and longitudinal direction. The observed changes in myocardial stresses and strains may result in poor global functioning of the heart.

Passive Biaxial Tensile Dataset of Three Main Rat Heart Myocardia: Left Ventricle, Mid-Wall and Right Ventricle

“…Mechanical properties of soft tissues have been utilized for decade in studying the mechanisms of diseases [1][2][3][4][5]. Accuracy of mechanical properties of soft tissues is vital in the developed of computational models.…”

“…Biventricular subject specific heart models have been used for decades to study various stages of cardiovascular diseases including myocardial infarction [6,7]. The accurate computational models are critical in the development of therapies for different diseases [2,8,9]. Currently, when building the computational models, the mechanical properties of the heart are assumed to be the same in all regions of the heart [10][11][12][13][14].…”

Sheep Sclera Soft Tissue Subjected to Mechanical Equi-Biaxial Testing

“…The constitutive models require accurate material parameters for the development of computational models. Computational models have been utilized to understand various mechanisms of diseases [5][6][7][8][9][10]. In this study, the equi-biaxial mechanical properties of the sheep sclera are presented.…”

Determination of Cross-directional and Cross-Wall Variations of Passive Biaxial Mechanical Properties of Rat Myocardium

“…Besides, other studies [12] further recommended that for cardiac tissue constitutive modelling, more uniaxial or biaxial tensile tests, identification of viscoelastic properties in various time scales, use of pressure-volume curves be carried out, and that there is need for correlating the passive biomechanical cardiac tissue properties with microstructural observations. Previous studies have been conducted to understand the tissue mechanics of healthy myocardia [13] to assist in the advancement of heart-specific computational models [1, 3,[14][15][16][17][18][19] and development of new materials for use in diagnosing and treatment of coronary illnesses. This study is aimed at investigating cross-direction and cross-wall variations in infarcted rat myocardium.…”