Details of regional particle deposition and airflow structures in a realistic model of human tracheobronchial airways: two-phase flow simulation

Rahimi‐Gorji, Mohammad; Gorji, Tahereh B.; Gorji-Bandpy, M.

doi:10.1016/j.compbiomed.2016.04.017

Cited by 137 publications

(60 citation statements)

References 27 publications

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“…Computational fluid dynamics (CFD) models have shown that increasing the flow rate enhances the extrathoracic deposition through the interaction between the airflow path and the surrounding mouth-throat geometry. Within the mouth-throat, the irregular surface and geometric deflections can form secondary flows, which can be strengthened by an increased inhalation flow rate, enhancing the deposition surrounding the larynx (Rahimi-Gorji et al, 2016). The sudden reduction in cross-sectional area at the glottis allows the formation of the laryngeal jet (Lin et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder

Yang

Verschuer

Shi

et al. 2016

International Journal of Pharmaceutics

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The present study investigates the effect of DPI resistance and inhalation flow rates on the lung deposition of orally inhaled mannitol dry powder. Mannitol powder radiolabeled with Tc-DTPA was inhaled from an Osmohaler™ by healthy human volunteers at 50-70L/min peak inhalation flow rate (PIFR) using both a low and high resistance Osmohaler™, and 110-130L/min PIFR using the low resistance Osmohaler™ (n=9). At 50-70L/min PIFR, the resistance of the Osmohaler™ did not significantly affect the total and peripheral lung deposition of inhaled mannitol [for low resistance Osmohaler™, 20% total lung deposition (TLD), 0.3 penetration index (PI); for high resistance Osmohaler™, 17% TLD, 0.23 PI]. Increasing the PIFR 50-70L/min to 110-130L/min (low resistance Osmohaler™) significantly reduced the total lung deposition (10% TLD) and the peripheral lung deposition (PI 0.21). The total lung deposition showed dependency on the in vitro FPF (R=1.0). On the other hand, the PI had a stronger association with the MMAD (R=1.0) than the FPF (R=0.7). In conclusion the resistance of Osmohaler™ did not significantly affect the total and regional lung deposition at 50-70L/min PIFR. Instead, the total and regional lung depositions are dependent on the particle size of the aerosol and inhalation flow rate, the latter itself affecting the particle size distribution.

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Section: Discussionmentioning

confidence: 99%

The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder

Yang

Verschuer

Shi

et al. 2016

International Journal of Pharmaceutics

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“…The SIMPLE algorithm was applied for the pressure-velocity coupling. A residual less than 5 10 − was used as the convergence criteria for airflow simulation. Discrete phase model (DPM) with steady particle tracking was used to investigate the transport and deposition of the dust particles in the airway mode.…”

Section: Methodsmentioning

confidence: 99%

“…Numerous CFD simulations of gas-particle flow have been performed in human airway models using Eulerian-Lagrangian approach [3][4][5][6][7] to investigate the transport and deposition of particles in human respiratory tract. In this approach, the fluid phase is modeled with Navier-Stokes equations, and the particle phase is modeled using a large amount of individual particles obeying the Newtonian laws of motion.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Transport and Deposition of Dust Particles in Human Tracheobronchial Airways

Tsega¹,

Katiyar²,

Gupta³

2019

IJBSE

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Dust is a common pollutant of the air we breath. If dust particles are inhaled and deposited in human airways, they can cause a variety of respiratory disorders. The inhaled dust particles motion in human airways goes along with the airflow. The transport process can be considered as a two-phase flow of a gas phase and a particle phase. In this study, we investigated the airflow and dust particles transport and deposition in human tracheobronchial airways using computational fluid dynamics (CFD) techniques. A steady simulation was performed in asymmetric tracheobronchial airway mode consisting of 19 outlets to observe the characteristics of airflow fields. The discrete phase model (DPM) was employed to predict the particle trajectories and deposition in the airway model. Deposition resulted from inertial impaction and gravitational sedimentation was considered. In the simulation, the airflow characteristics differences in the right and left bronchial trees were observed. The influence of secondary flow on dust particles motion was great. More dust particles were deposited in the right bronchial tree than in the left. The deposition fraction of dust particles in human tracheobronchial airways was high. This study can provide awareness on deposition of dust particles passing beyond the larynx and enhance prevention of their entry into the respiratory system. It can also contribute a convenient way on the location of deposition of particles of a given type in human respiratory tract to be used for respiratory disease preventions.

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“…Computational approaches, such as computational fluid dynamics (CFD), are very useful to investigate the HTC for different engineering problems [22]- [24]. Mousavi et al [19] implemented a CFD study to assess the influence of magnetic field on heat transfer of magnetic Fe3O4/water nanofluid (4 vol.…”

Section: Introductionmentioning

confidence: 99%

The influence of magnetic field on heat transfer of magnetic nanofluid in a double pipe heat exchanger proposed in a small-scale CAES system

Malekan

Khosravi

Zhao

2019

Applied Thermal Engineering

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Globally, the integration of renewable energy (which has an intermittent nature) into the power system requires the system operators to improve the system performance to be able to effectively handle the variations of the power production in order to balance the supply and demand. This problem is seen as a major obstacle to the expansion of renewable energy if it is not handled in a suitable way. Efficient electricity storage technology is one of the feasible solutions. The current study proposes Fe3O4/water nanofluid under magnetic field as the secondary fluid in the proposed double pipe heat exchanger before the cavern. The heat of compressed air is absorbed by the secondary fluid and it is stored in an isolation tank. This stored fluid is used to warm up the air that leaves the cavern for expanding in the turbine. The results demonstrated that increasing the mass flow rate of secondary fluid decreases the cavern temperature. Also, the value of convective heat transfer of ferrofluid increases when the volume fraction of nanoparticle as well as magnetic field increases. Furthermore, increasing the volume fraction and magnetic field increases the pressure drop and friction factor of ferrofluid.

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Details of regional particle deposition and airflow structures in a realistic model of human tracheobronchial airways: two-phase flow simulation

Cited by 137 publications

References 27 publications

The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder

The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder

Numerical Simulation of Transport and Deposition of Dust Particles in Human Tracheobronchial Airways

The influence of magnetic field on heat transfer of magnetic nanofluid in a double pipe heat exchanger proposed in a small-scale CAES system

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