Detección de iones metálicos en cabello tras artroplastia de cadera metal-metal

The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, the Cobalt-Chromium-Molybdenum (Co-Cr-Mo) and Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant in joint prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, and corrosion resistance. Nonetheless, over time, the physical wear, electrochemical corrosion, and inflammation induced by these alloys that occur post-implantation can cause the release of various metallic components. The released metals can then flow and metabolize in vivo, subsequently causing potential local or systemic harm. This review first details joint prosthesis development and acknowledges the release of prosthetic metals. Second, we outline the metallic concentration, biodistribution, and elimination pathways of the released prosthetic metals. Lastly, we discuss the possible organ, cellular, critical biomolecules, and significant signaling pathway toxicities and adverse effects that arise from exposure to these metals.

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Detección de iones metálicos en cabello tras artroplastia de cadera metal-metal

Cited by 3 publications

References 29 publications

Cobalt toxicity after revision total hip replacement due to fracture of a ceramic head

Cobalt toxicity after revision total hip replacement due to fracture of a ceramic head

Elevated blood metal ion levels in patients undergoing instrumented spinal surgery: a systematic review and meta-analysis

Prosthetic Metals: Release, Metabolism and Toxicity

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