Detectability of hypervascularity in early dynamic PET depends on tracer kinetics: ¹⁸F‐FDG versus ⁶⁸Ga‐DOTATOC in hepatic NET metastasis

Abstract

Detectability of hypervascularity in early dynamic PET depends on tracer kinetics: 18 F-FDG versus 68 Ga-DOTATOC in hepatic NET metastasis Contrast-enhanced computed tomography of a 54-yearold woman with pancreatic cancer showed a hypervascular liver lesion (upper row, Fig. 1). Suspecting a pancreatic neuroendocrine tumour with liver metastases, we separately performed positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG), 245 MBq, and 68 Ga-DOTATOC (DOTATOC), 158 MBq, to exclude poor tumour differentiation and evaluate somatostatin receptors.Before conventional late static imaging, we performed early dynamic PET (edPET), with pictures continuously acquired for 90 s starting with bolus tracer injection. Both edPET image sets (second, third rows) depicted a very early signal increase with an inhomogeneous centre Liver International (2014)

Continued rapid growth in 68Ga applications: update 2013 to June 2014

“…The pre‐radiotherapeutic ([ 90 Y]‐DOTA‐LAN) SSTR status was assessed using [ 68 Ga]Ga‐DOTA‐LAN with subsequent radiotherapy response making possible the surgical resection and successful patient recovery . In addition, the concept of using [ 18 F]FDG early dynamic (ed)PET for the assessment of liver lesion hypervascularization was applied to [ 68 Ga]Ga‐DOTA‐TOC/edPET; however, the high first‐pass extraction rate masked the typical signal peak and decline and prevented the methodology translation …”

Early dynamic PET/CT shows open portocaval shunt in a patient with liver cirrhosis

“…A 67‐year‐old male with hepatocellular carcinoma and severe cirrhosis was referred to our department for exclusion of extrahepatic metastases prior to liver transplantation. To assess for tumour vascularization, early dynamic positron emission tomography/computed tomography (edPET/CT) was conducted according to an established protocol: A continuous series of images of the liver was acquired for 4 min starting with injection of 18F‐Fluorodeoxyglucose, 250 MBq, dissolved in 10 ml of 0.9% saline as a 3 ml/sec bolus . There was no early arterial hypervascularization of the tumour (Fig.…”