Detectable <scp>CD</scp>8 cells correlate with improved overall survival in adult B lymphoblastic leukaemia patients

Löw, Michael; Lee, Denise; McLean, Catriona; Nguyen, Trung Van; Morgan, Sue; Grigoriadis, George

doi:10.1111/bjh.12794

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Next, psychopathy, like empathy, is multifaceted, and includes as key features: (i) impulsivity; (ii) failure to adopt interpersonal conventions of honesty, modesty and trustworthiness; (iii) failure to experience genuine emotions regarding others (e.g. love, empathy, guilt); (iv) failure to adopt prevailing sociocultural norms pertaining to financial responsibility and safe conduct; and (v) failure to obey the laws of a given society [55,56]. Importantly, individuals with psychopathy may be normative or high in cognitive empathy, yet low in affective empathy, in particular, empathic concern [57] — this combination could facilitate characteristic interpersonal exploitation observed in psychopathic individuals [58].…”

Section: Methodsmentioning

confidence: 99%

Explicating the role of empathic processes in substance use disorders: A conceptual framework and research agenda

Massey

Newmark

Wakschlag

2017

Drug and Alcohol Review

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Adults with alcohol and stimulant use disorders exhibited detectable impairments in both cognitive and affective empathy, measured behaviourally, neuroanatomically and by self-report, relative to controls. There were no developmental studies specifically designed to test the role of empathy in substance use pathways, but several studies that included measures of empathy suggest that empathy may be protective. Studies on severe empathic deficits were mixed regarding a unique role of empathy in substance use trajectories, independent of interpersonal style, impulsivity and social deviance. Implications and Conclusions. In the context of findings and methodological limitations of this review, we recommend more rigorous examination of empathy across the spectrum of substance use behaviour. Future work should utilise the following: (i) prospective assessment of empathic capacity in substance abusers during and following treatment; (ii) large, developmentally based prospective designs beginning prior to substance initiation incorporating multiple measures of empathy; (iii) assessment of the moderating role of gender, race and ethnicity; and (iv) prospective study of empathy in children at elevated risk for substance use disorders. [Massey SH, Newmark RL, Wakschlag LS. Explicating the role of empathic processes in substance use disorders: A conceptual framework and research agenda.

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Section: Methodsmentioning

confidence: 99%

Explicating the role of empathic processes in substance use disorders: A conceptual framework and research agenda

Massey

Newmark

Wakschlag

2017

Drug and Alcohol Review

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“…Several parameters associated with the composition of immune infiltrate in solid tumours have been shown to correlate with prognosis, and in some instances, to predict patient survival more accurately than any other parameter . In B‐ALL, two recent reports examining the immunological composition of bone marrow (BM) at diagnosis demonstrate correlation between CD4 + (where CD is cluster of differentiation) T lymphocytes and favourable early response in paediatric patients and CD8 + T lymphocytes and improved OS in adult patients . In this study, we examined the composition at diagnosis of non‐malignant lymphocytes in the BM of paediatric patients with B‐ALL.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 In B-ALL, two recent reports examining the immunological composition of bone marrow (BM) at diagnosis demonstrate correlation between CD4 + (where CD is cluster of differentiation) T lymphocytes and favourable early response in paediatric patients 4 and CD8 + T lymphocytes and improved OS in adult patients. 5 In this study, we examined the composition at diagnosis of non-malignant lymphocytes in the BM of paediatric patients with B-ALL. We aimed to identify whether non-malignant lymphocytes routinely measured in BM aspirate by flow cytometry are associated with OS.…”

Section: Introductionmentioning

confidence: 99%

Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

Edwin

Dean

Bonnett

et al. 2016

Pediatric Blood & Cancer

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Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B‐cell acute lymphoblastic leukaemia. Our analysis identified a sub‐group (∼30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub‐group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.

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“…Adult B acute lymphoblastic leukemia (B-ALL) has a poor prognosis, with a 5-year overall survival of approximately 35% [ 1 ]. Although treatments have notably improved over the past decade, the outcomes in adults remain unfavorable due to high chemoresistance or relapse [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Suppression of miR-708 inhibits the Wnt/β-catenin signaling pathway by activating DKK3 in adult B-all

Zhang

Cao

et al. 2017

Oncotarget

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Inactivation of Dickkopf-3 (DKK3) is closely associated with a poor prognosis in various solid tumor and hematologic malignancies. Promoter hypermethylation is one potential cause of DKK3 inactivation. However, whether other mechanisms lead to DKK3 inactivation and the subsequent effects of these inactivations on cell proliferation and the Wnt signaling pathway in adult B acute lymphoblastic leukemia (B-ALL) remain unclear. In the present study, we found that low DKK3 expression levels were associated with high miR-708 expression and promoter hypermethylation in adult B-ALL. miR-708 was confirmed to directly decrease DKK3 expression in Nalm-6 and BALL-1 cells. Additionally, a miR-708 inhibitor decreased cell proliferation mainly through apoptosis and cell cycle arrest at the G1 phase, and these effects were eliminated by DKK3 siRNA treatment. Moreover, the demethylating agent 5-aza-2′-deoxycytidine (5-aza) decreased the methylation state of the DKK3 promoter based on methylation-specific PCR (MSP) and bisulfite genomic sequencing PCR (BSP), although this demethylation effect was not enhanced by the miR-708 inhibitor. The miR-708 inhibitor or 5-aza significantly increased DKK3 expression and decreased p-GSK3β, cyclin D1 and nuclear and cytoplasmic β-catenin protein expression, indicating that the Wnt/β-catenin signaling pathway was inhibited. These effects became more pronounced when the miR-708 inhibitor and 5-aza were used simultaneously. These findings provide greater insights into the mechanisms that increase DKK3 expression and suggest that a miR-708 inhibitor and 5-aza might be useful as targeted therapies for adult B-ALL.

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Detectable CD8 cells correlate with improved overall survival in adult B lymphoblastic leukaemia patients

Cited by 5 publications

References 11 publications

Explicating the role of empathic processes in substance use disorders: A conceptual framework and research agenda

Explicating the role of empathic processes in substance use disorders: A conceptual framework and research agenda

Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

Suppression of miR-708 inhibits the Wnt/β-catenin signaling pathway by activating DKK3 in adult B-all

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