Detecting colorectal cancer using electrical impedance spectroscopy: an<i>ex vivo</i>feasibility study

Pathiraja, Angela; Ziprin, Paul; Shiraz, Arsam; Mirnezami, Reza; Tizzard, Andrew; Brown, Brian; Demosthenous, Andreas; Bayford, Richard

doi:10.1088/1361-6579/aa68ce

Cited by 19 publications

(15 citation statements)

References 24 publications

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“…Previous research suggested that GNPs has the potential as a contrast agent for bioimpedance measurements [15] and it is possible to detect cancer cells based on the impedance increase [16]. However, the addition of GNPs to decrease impedance in cancer cells would limit the ability to distinguish between GNPs and cancer cells.…”

Section: A Gnps As Contrast Agentsmentioning

confidence: 99%

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

Bayford

Damaso

Neshatvar

et al. 2022

IEEE Trans. Biomed. Eng.

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Section: A Gnps As Contrast Agentsmentioning

confidence: 99%

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

Bayford

Damaso

Neshatvar

et al. 2022

IEEE Trans. Biomed. Eng.

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“…It has a wide range of applications that can help in clinical status monitoring and diagnosis of diseases [2]. Example applications include human-machine interfaces [3], lung function monitoring [4], drug-screening [5], biosensing [6], and cancer detection [7].…”

Section: Introductionmentioning

confidence: 99%

Time Stamp – A Novel Time-to-Digital Demodulation Method for Bioimpedance Implant Applications

Jiang

Habibollahi

et al. 2020

IEEE Trans. Biomed. Circuits Syst.

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Bioimpedance analysis is a non-invasive and inexpensive technology to investigate the electrical properties of biological tissues. The analysis requires demodulation to extract the real and imaginary parts of the impedance. Conventional systems use complex architectures such as I-Q demodulation. In this paper, a very simple alternative time-to-digital demodulation method or 'time stamp' is proposed. It employs only three comparators to identify or stamp in the time domain, the crossing points of the excitation signal and the measured signal. In a CMOS proof of concept design, the accuracy of impedance magnitude and phase is 97.06% and 98.81% respectively over a bandwidth of 10 kHz to 500 kHz. The effect of fractional-N synthesis is analysed for the counter-based zero crossing phase detector obtaining a finer phase resolution (0.51˚ at 500 kHz) using a counter clock frequency (= 12.5 MHz). Because of its circuit simplicity and ease of transmitting the time stamps, the method is very suited to implantable devices requiring low area and power consumption.

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“…As an electrochemical analysis technique, EIS has historically been used industrially for monitoring corrosion (Angelini et al 2006) and battery efficiency (Din et al 2016), while its use for medical applications is less well established (Pathiraja et al 2017). EIS relies on the physical and chemical properties of molecules to alter the transmission of electrical current (Carminati and Li 2017).…”

Section: Introductionmentioning

confidence: 99%

POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

Sawhney

Conlan

2019

Biomed Microdevices

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Point-of-care medical devices offer the potential for rapid biomarker detection and reporting of medical conditions, thereby bypassing the requirements for offline clinical laboratory facilities in many cases. Label-free electrochemical techniques are suitable for use in handheld diagnostic devices due the inherent electronic detection modality and low requirement for processing reagents. While electrochemical impedance sensing is widely used in tissue analysis such as body composition measurement, its use in point-of-care patient testing is yet to be widely adopted. Here we have considered a number of issues currently limiting the translation of electrochemical impedance sensing into clinical biosensor devices. Specifically, we have addressed the current requirement for these sensors to be connected to an external processor by applying a minimum number of frequencies required for optimized biomarker detection, and subsequently delivering analytics within the measurement device. The POISED-5 device was evaluated using a sensor for the ovarian cancer biomarker cancer antigen 125 (CA125), demonstrating performance comparable to standard laboratory equipment, with direct interpretation of response signal amplitude substituting traditional impedance component calculation and model fitting.

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Detecting colorectal cancer using electrical impedance spectroscopy: anex vivofeasibility study

Cited by 19 publications

References 24 publications

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

Time Stamp – A Novel Time-to-Digital Demodulation Method for Bioimpedance Implant Applications

POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

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