Detecting congenital malformations - Lessons learned from the Mpepu study, Botswana

Ajibola, Gbolahan; Zash, Rebecca; Shapiro, Roger; Batlang, Oganne; Botebele, Kerapetse; Bennett, Kara; Chilisa, Florence; Widenfelt, Erik von; Makhema, Joseph; Lockman, Shahin; Holmes, Lewis B.; Powis, Kathleen M.

doi:10.1371/journal.pone.0173800

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Our study is one of the few studies reporting adverse birth outcomes among adolescent women in Sub-Saharan Africa. [30] Our results corroborate previous ndings on birth outcomes and demonstrate that adolescent pregnancy is a risk factor for several neonatal adverse birth…”

Section: Resultssupporting

confidence: 92%

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Serunjogi

Barlow‐Mosha

Mumpe-Mwanja

et al. 2020

Preprint

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Background: Uganda has one of the highest adolescent pregnancy rates in sub-Saharan Africa. We compared the risk of adverse birth outcomes between adolescents (age 12-19 years) and older mothers (age 20-34 years) in four urban hospitals.Methods: Maternal demographics, HIV status, and birth outcomes of all live births, stillbirths, and spontaneous abortions delivered from August 2015 to December 2018 were extracted from a hospital-based birth defects surveillance database. Differences in the distributions of maternal and infant characteristics by maternal age groups were tested with Pearson’s chi-square. Adjusted odds ratios (aORs) and 95% Confidence Intervals (CI) were calculated using logistic regression to compare the prevalence of adverse birth outcomes among adolescents to older mothers.Results: A total of 100,189 births were analyzed, with 11.1% among adolescent mothers and 89.0% among older mothers. A significantly higher proportion of HIV-infected adolescents were not initiated on antiretroviral therapy by the time of delivery compared to HIV-infected older mothers (8.8% vs 4.4%, p<0.001). Adolescent mothers had an increased risk of preterm delivery (aOR: 1.14; CI: 1.06-1.23), low birth weight (aOR: 1.46; CI: 1.34-1.59), and early neonatal deaths (aOR: 1.58; CI: 1.23-2.02). Newborns of adolescent mothers had an increased risk of major external birth defects (aOR: 1.33; CI: 1.02-1.76), specifically, gastroschisis (aOR: 3.20; CI: 1.12-9.13) compared to older mothers.Conclusions: This study found that adolescent mothers had an increased risk for several adverse birth outcomes compared to older mothers, similar to findings in the region and globally. Interventions are needed to improve birth outcomes in this vulnerable population.

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Section: Resultssupporting

confidence: 92%

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Serunjogi

Barlow‐Mosha

Mumpe-Mwanja

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Our study is one of the few studies reporting adverse birth outcomes among adolescent women in sub-Saharan Africa. [32] Our results corroborate previous ndings in developed countries on birth outcomes and demonstrate that adolescent pregnancy is a risk factor for several neonatal adverse birth outcomes. With the growing population and high rates of adolescent pregnancy in Africa, the number of adverse birth outcomes is likely to increase and thereby remain a key public health concern.…”

Section: Resultssupporting

confidence: 92%

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Serunjogi

Barlow‐Mosha

Mumpe-Mwanja

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Uganda has one of the highest adolescent pregnancy rates in sub-Saharan Africa. We compared the risk of adverse birth outcomes between adolescents (age 12-19 years) and older mothers (age 20-34 years) in four urban hospitals.Methods: Maternal demographics, HIV status, and birth outcomes of all live births, stillbirths, and spontaneous abortions delivered from August 2015 to December 2018 were extracted from a hospital-based birth defects surveillance database. Differences in the distributions of maternal and infant characteristics by maternal age groups were tested with Pearson’s chi-square. Adjusted odds ratios (aORs) and 95% Confidence Intervals (CI) were calculated using logistic regression to compare the prevalence of adverse birth outcomes among adolescents to older mothers.Results: A total of 100,189 births were analyzed, with 11.1% among adolescent mothers and 89.0% among older mothers. Adolescent mothers had an increased risk of preterm delivery (aOR: 1.14; CI: 1.06-1.23), low birth weight (aOR: 1.46; CI: 1.34-1.59), and early neonatal deaths (aOR: 1.58; CI: 1.23-2.02). Newborns of adolescent mothers had an increased risk of major external birth defects (aOR: 1.33; CI: 1.02-1.76), specifically, gastroschisis (aOR: 3.20; CI: 1.12-9.13) compared to older mothers. The difference between the prevalence of gastroschisis among adolescent mothers (7.3 per 10,000 births; 95% CI: 3.7-14.3) was statistically significant when compared to older mothers (1.6 per 10,000 births; 95% CI: 0.9-2.6).Conclusions: This study found that adolescent mothers had an increased risk for several adverse birth outcomes compared to older mothers, similar to findings in the region and globally. Interventions are needed to improve birth outcomes in this vulnerable population.

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“…In this systematic review and meta-analysis, 60 articles, which included about 3,091,946 births and 52,569 congenital anomalies, were analyzed. Of these, 4 studies were conducted in Ethiopia [ 30 – 33 ]; 16 studies were conducted in Nigeria [ 34 – 48 ]; 9 studies were conducted in Egypt [ 49 – 59 ]; 3 studies were conducted in South Africa [ 60 – 64 ]; 5 studies were conducted in Morocco [ 65 – 69 ]; 6 studies were conducted in Libya [ 70 – 75 ]; 2 studies were conducted in Tunisia [ 76 – 79 ]; and 7 studies were conducted in Mozambique [ 80 ], Botswana [ 81 ], Cameroon [ 82 ], the DRC [ 83 ], Malawi [ 84 ], Zambia [ 85 ], Gabon [ 86 ], and Uganda [ 87 ]. Two studies were from Sudan [ 88 , 89 ].…”

Section: Resultsmentioning

confidence: 99%

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Gebremeskel

Gedion

2022

The Scientific World Journal

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Introduction. Worldwide, surveys have shown that the frequency of chromosomal disorders among births with congenital anomalies varies greatly from country to country. It is well known that chromosomal disorders are an important cause of premature death or life-long disability; however, the absence of local epidemiological data on their birth prevalence and outcomes impedes policy and service development in many countries and continents. Therefore, the current systematic review and meta-analysis intend to show the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa. Methods. From PubMed, Cochrane Library, and Google Scholar, we systematically reviewed and meta-analyzed the studies that examined the incidence, prevalence, and types of chromosomal disorders using PRISMA guidelines. A weighted inverse variance random-effects model was used to estimate the pooled proportion of chromosomal disorders among births with congenital anomalies. Results. From the total of 3,569 studies identified, 1,442 were from PubMed, 108 were from Cochrane Library, 1,830 were from Google Scholar, and 189 were from other sources. After duplication was removed, a total of 844 articles remained (2725 were removed by duplication). Finally, 144 full-text studies were reviewed and 60 articles with 52,569 births having congenital anomalies met the inclusion criteria and were selected for this meta-analysis. The pooled proportion of chromosomal disorders among births with congenital anomalies was 8.94% (95% CI; 7.02, 10.86; I2 = 98.8%; p < 0.001 ). Conclusions and Future Implications. In the current systematic review and meta-analysis, the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa was small. Down syndrome (trisomy 21) accounted for more than 80% of chromosomal disorders. The pooled proportion of chromosome disorders was the highest in North African regions and countries compared to other regions of the continent. Healthcare managers should focus on establishing proper cytogenetic diagnostic facilities in collaboration with well-trained genetic counseling services in the continent.

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Detecting congenital malformations - Lessons learned from the Mpepu study, Botswana

Cited by 8 publications

References 12 publications

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Adverse Neonatal Birth Outcomes Among Adolescent Pregnancies in Kampala, Uganda Between 2015 –2018

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

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