Radio signals which reach the receiving antenna by two or more paths will result in a propagation phenomenon called multipath. It is one common propagation phenomenon in wireless telecommunications. Concept of the multipath is also one of teaching contents in electronic and electrical engineering studies. Along with the rapid development of digital computational technology, CAI (“computer aided instruction”) has become one powerful tool widely applied in teaching and study. Based on convolution analysis from time‐domain analysis and Pade approximation from the S‐transform domain, Simulink‐based teaching design upon elimination of the multipath‐effect is presented in this study. Designs of inverse systems for eliminating the multipath‐effect are implemented in two approaches. One is the Pade approximation‐based approach, which is implemented by rational continuous‐time LTI (“linear Time Invariant”) models from the perspective of S‐transform‐domain analysis. Another is the convolution analysis‐based approach called deconvolution, which is implemented in one amendment approach to gradually eliminate the multipath‐effect from the perspective of time‐domain analysis. The teaching design has been integrated into a basic course of “signals and systems” for undergraduate students at Hunan University of Science and Technology, China in recent years. Simulations and feedback results in teaching practice indicate workability of the presented method. Compared to its physical implement, the Simulink‐based method provides one graphical virtual approach in a convenient and vivid way. The proposed teaching design may benefit electronic and electrical engineering studies.