Detecting functional decline from normal aging to dementia: Development and validation of a short version of the Amsterdam IADL Questionnaire

Jutten, Roos J.; Peeters, Carel F.W.; Leijdesdorff, Sophie; Visser, Pieter Jelle; Maier, Andrea B.; Terwee, Caroline B.; Scheltens, Philip; Sikkes, Sietske A.M.

doi:10.1016/j.dadm.2017.03.002

Cited by 79 publications

(137 citation statements)

References 59 publications

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“…The FAQ has been described as one of the more sensitive functional questionnaires for people with early-stage dementia 44,70 with studies recommending its use to distinguish mild cognitive decline from dementia. 71,72 However, while the brevity of the FAQ ensures suitability for people with dementia, it is likely that important aspects of functional ability have been omitted from the measure, such as those included in the Amsterdam Instrumental Activity of Daily Living Questionnaire; 73,74 we previously modified the FAQ to include a question on telephone use. 30 Our findings suggest that for some people with early-stage dementia, the FAQ may not have adequate sensitivity to identify perceived functional difficulties.…”

Section: Discussionmentioning

confidence: 99%

The relationship between perceived functional difficulties and the ability to live well with mild‐to‐moderate dementia: Findings from the IDEAL programme

Martyr

Nelis

Quinn

et al. 2019

Int J Geriat Psychiatry

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Objectives The objectives of the study are to investigate how different levels of functional ability relate to quality of life, well‐being, and satisfaction with life, conceptualised as reflecting capability to “live well” in people with dementia. Methods/design Participants were 1496 people with mild‐to‐moderate dementia and 1188 informants who completed baseline assessments in the Improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort study. Total self‐rated and informant‐rated scores on the Functional Activities Questionnaire were split into six ability levels to monitor how poorer functioning impacts the ability to live well. We also investigated the potential influence of sociodemographic and diagnostic variables, depression, cognition, and carer stress. Results Multivariate multiple regression models found that people with dementia who had the greatest functional impairment according to self‐ratings and informant ratings had poorer living well scores than those with the least functional impairment. Sociodemographic and diagnostic factors and cognition had little impact on effect sizes. For self‐ratings, depression attenuated the relationship between functional ability and living well, whereas carer stress attenuated informant ratings. Conclusions People with dementia with the least functional impairments had greater capability to live well than those with the most functional impairment. Even subtle perceived difficulties in functional ability had a detrimental effect on the ability of people with dementia to live well. Depression in people with dementia and carer stress in informants influenced these associations, and therefore, these factors should be routinely included in future research studies and clinical assessments.

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Section: Discussionmentioning

confidence: 99%

The relationship between perceived functional difficulties and the ability to live well with mild‐to‐moderate dementia: Findings from the IDEAL programme

Martyr

Nelis

Quinn

et al. 2019

Int J Geriat Psychiatry

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“…The A‐IADL‐Q is an informant‐based questionnaire covering a broad range of complex IADLs such as household, administration, work, computer use, leisure time, appliances, and transport activities. For the present study, the short version was used, consisting of 30 items [11]. For each item, difficulty in performance is rated on a 5‐point Likert scale (ranging from “no difficulty in performing this task” to “no longer able to perform this task”).…”

Section: Methodsmentioning

confidence: 99%

“…An independent blinded person entered the answers on an online version of the questionnaire. We used the short version of A-IADL-Q because it has the same psychometric quality than the original version and it is shorter thus more user friendly/less burdensome to the informant [11]. Results were compiled and extracted for each patient and each visit of the 3-year follow-up (M0, M12, M24, and M36).…”

Section: Amsterdam Iadl Questionnairementioning

confidence: 99%

“…The initial version of the A‐IADL‐Q was an adaptive 47‐ to 70‐item questionnaire, covering a broad range of cognitive IADLs, aimed to detect early dementia and early‐onset dementia. The A‐IADL‐Q short version has been recently developed and has maintained the psychometric quality of the original version [11]. It consists of 30 items (derived from the original version) that can be used to detect functional decline from normal aging to dementia.…”

Section: Introductionmentioning

confidence: 99%

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Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease

Villeneuve¹,

Houot²,

Cacciamani

et al. 2019

A&D Transl Res & Clin Interv

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IntroductionTrials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance.MethodsWe assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q).ResultsNo overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load (P = .0005), and lower education (P = .0392).DiscussionThe A-IADL-Q identified a subtle functional decline in asymptomatic at-risk AD individuals. This could have important implications in the field of early intervention in AD.

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“…Assess instrumental activities with scales overcoming typical cultural limitations, like the A-IADL [8,44] R-II, 3-0-2…”

Section: Baseline General Assessment (T0)mentioning

confidence: 99%

Italian consensus recommendations for a biomarker‐based aetiological diagnosis in mild cognitive impairment patients

Boccardi

Nicolosi

Festari

et al. 2019

Euro J of Neurology

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Background and purpose Biomarkers support the aetiological diagnosis of neurocognitive disorders in vivo. Incomplete evidence is available to drive clinical decisions; available diagnostic algorithms are generic and not very helpful in clinical practice. The aim was to develop a biomarker‐based diagnostic algorithm for mild cognitive impairment patients, leveraging on knowledge from recognized national experts. Methods With a Delphi procedure, experienced clinicians making variable use of biomarkers in clinical practice and representing five Italian scientific societies (neurology – Società Italiana di Neurologia per le Demenze; neuroradiology – Associazione Italiana di Neuroradiologia; biochemistry – Società Italiana di Biochimica Clinica; psychogeriatrics – Associazione Italiana di Psicogeriatria; nuclear medicine – Associazione Italiana di Medicina Nucleare) defined the theoretical framework, relevant literature, the diagnostic issues to be addressed and the diagnostic algorithm. An N–1 majority defined consensus achievement. Results The panellists chose the 2011 National Institute on Aging and Alzheimer's Association diagnostic criteria as the reference theoretical framework and defined the algorithm in seven Delphi rounds. The algorithm includes baseline clinical and cognitive assessment, blood examination, and magnetic resonance imaging with exclusionary and inclusionary roles; dopamine transporter single‐photon emission computed tomography (if no/unclear parkinsonism) or metaiodobenzylguanidine cardiac scintigraphy for suspected dementia with Lewy bodies with clear parkinsonism (round VII, votes (yes‐no‐abstained): 3‐1‐1); 18F‐fluorodeoxyglucose positron emission tomography for suspected frontotemporal lobar degeneration and low diagnostic confidence of Alzheimer’s disease (round VII, 4‐0‐1); cerebrospinal fluid for suspected Alzheimer’s disease (round IV, 4‐1‐0); and amyloid positron emission tomography if cerebrospinal fluid was not possible/accepted (round V, 4‐1‐0) or inconclusive (round VI, 5‐0‐0). Conclusions These consensus recommendations can guide clinicians in the biomarker‐based aetiological diagnosis of mild cognitive impairment, whilst guidelines cannot be defined with evidence‐to‐decision procedures due to incomplete evidence.

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Detecting functional decline from normal aging to dementia: Development and validation of a short version of the Amsterdam IADL Questionnaire

Cited by 79 publications

References 59 publications

The relationship between perceived functional difficulties and the ability to live well with mild‐to‐moderate dementia: Findings from the IDEAL programme

The relationship between perceived functional difficulties and the ability to live well with mild‐to‐moderate dementia: Findings from the IDEAL programme

Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease

Italian consensus recommendations for a biomarker‐based aetiological diagnosis in mild cognitive impairment patients

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