Detecting lung infections in breathprints: empty promise or next generation diagnosis of infections

Haick, Hossam; Cohen‐Kaminsky, Sylvia

doi:10.1183/09031936.00183714

Cited by 15 publications

(11 citation statements)

References 27 publications

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“…For example, a distinctive smell is well recognized in cases of increased bacterial activity such as sinus‐related illness and tonsillitis (Ferguson, Aydin, & Mickel, ). In adults, both acute and chronic respiratory diseases result in significant shifts in the exhaled volatolome (Haick & Cohen‐Kaminsky, ). Respiratory diseases can induce an unpleasant odor described as “acidic” or “cheesy” in the exhaled breath (Bollen & Beikler, ).…”

Section: Non‐sulfuric Vocs Contributing To Halitosismentioning

confidence: 99%

Detection of halitosis in breath: Between the past, present, and future

2017

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To develop a new generation of diagnostics for halitosis, replacing the subjective organoleptic assessment, a series of exhaled breath analyzers has been developed and assessed. All three devices rely on the assessment of exhaled volatile sulfuric compounds (VSCs), which are mainly generated in and emitted from the oral cavity, contributing to the malodor. Portable, on-site and easy to use, these devices have potential for non-invasive diagnosis of halitosis. However, global assessment of exhaled VSCs alone has two main drawbacks: (i) the absence of VSCs does not rule out halitosis; (ii) non-sulfuric volatile compounds that could be biomarkers of systemic diseases, found in up to 15% of halitosis cases, are neglected. In this article, we review and discuss progress to date in the field of oral/exhaled volatile compounds as potential noninvasive diagnostics for halitosis. We will briefly describe the generation of these compounds both from local (oral) and distal (extra-oral) sources. In addition, we debate the different analytical approaches in use and discuss the potential value of bio-inspired artificially intelligent olfaction in diagnosing and classifying oral and systemic diseases by analyzing exhaled breath.

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Section: Non‐sulfuric Vocs Contributing To Halitosismentioning

confidence: 99%

Detection of halitosis in breath: Between the past, present, and future

2017

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“…Recently, the gas sensors have found a new potential in medical applications such as detection of various volatile organic compounds (VOCs), which can be considered as biomarkers related to different diseases—especially pulmonary ones [1,2]. Their biggest advantage comes from the non-invasiveness of patient screening via VOC breath-prints produced mainly through changes in specific biochemical pathways in the body [3].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Polypyrrole-Based Ammonia and Volatile Organic Compound Sensors

Šetka

Drbohlavová

Hubálek

2017

Sensors

114

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The aim of this review is to summarize the recent progress in the fabrication of efficient nanostructured polymer-based sensors with special focus on polypyrrole. The correlation between physico-chemical parameters, mainly morphology of various polypyrrole nanostructures, and their sensitivity towards selected gas and volatile organic compounds (VOC) is provided. The different approaches of polypyrrole modification with other functional materials are also discussed. With respect to possible sensors application in medicine, namely in the diagnosis of diseases via the detection of volatile biomarkers from human breath, the sensor interaction with humidity is described as well. The major attention is paid to analytes such as ammonia and various alcohols.

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“…Pathophysiological events affecting the lung can increase or modify the presence of VOCs in the exhaled breath changing its profile, called exhaled volatome. As they are not detected in the peripheral blood system, they are not metabolised or stored in the fat compartment [44,45]. Given these considerations, VOCs have been suggested as noninvasive biomarkers in numerous diseases, included PH.…”

Section: Biomarkers Research For Early Diagnosis and Prognosismentioning

confidence: 99%

Pulmonary hypertension and chronic lung disease: where are we headed?

et al. 2019

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Pulmonary hypertension related to chronic lung disease, mainly represented by COPD and idiopathic pulmonary fibrosis, is associated with a worse outcome when compared with patients only affected by parenchymal lung disease. At present, no therapies are available to reverse or slow down the pathological process of this condition and most of the clinical trials conducted to date have had no clinically significant impact. Nevertheless, the importance of chronic lung diseases is always more widely recognised and, along with its increasing incidence, associated pulmonary hypertension is also expected to be growing in frequency and as a health burden worldwide. Therefore, it is desirable to develop useful and reliable tools to obtain an early diagnosis and to monitor and follow-up this condition, while new insights in the therapeutic approach are explored.

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Detecting lung infections in breathprints: empty promise or next generation diagnosis of infections

Cited by 15 publications

References 27 publications

Detection of halitosis in breath: Between the past, present, and future

Detection of halitosis in breath: Between the past, present, and future

Nanostructured Polypyrrole-Based Ammonia and Volatile Organic Compound Sensors

Pulmonary hypertension and chronic lung disease: where are we headed?

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