Detecting papillary neovascularization in proliferative diabetic retinopathy using optical coherence tomography angiography

Savastano, Maria Cristina; Federici, Matteo; Falsini, Benedetto; Caporossi, Aldo; Minnella, Angelo Maria

doi:10.1111/aos.13166

Cited by 36 publications

(31 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While FA is currently a better method than OCTA for detecting NV due the much wider field of view, dye leakage on FA can obscure the morphology, so the borders of retinal NV may be better delineated on OCTA (Savastano, et al, 2016). Studies show that NV lesions are similar in shape and size in OCTA compared to FA (Yu, et al, 2016).…”

Section: 8 Neovascularizationmentioning

confidence: 99%

OCT angiography and visible-light OCT in diabetic retinopathy

et al. 2017

View full text Add to dashboard Cite

In recent years, advances in optical coherence tomography (OCT) techniques have increased our understanding of diabetic retinopathy, an important microvascular complication of diabetes. OCT angiography is a non-invasive method that visualizes the retinal vasculature by detecting motion contrast from flowing blood. Visible-light OCT shows promise as a novel technique for quantifying retinal hypoxia by measuring the retinal oxygen delivery and metabolic rates. In this article, we discuss recent insights provided by these techniques into the vascular pathophysiology of diabetic retinopathy. The next milestones for these modalities are large multicenter studies to establish consensus on the most reliable and consistent outcome parameters to study diabetic retinopathy.

show abstract

Section: 8 Neovascularizationmentioning

confidence: 99%

OCT angiography and visible-light OCT in diabetic retinopathy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Conversely, smaller microaneurysms which can be detected with OCT‐A may not be seen with classical angiography because of limited resolution or dye leakage. OCT‐A can also be used to visualise retinal neovascularisation, which is seen to project into the vitreous cavity (Figure ) …”

Section: Applications In Retinal Diseasementioning

confidence: 99%

Future clinical applicability of optical coherence tomography angiography

Chua

Tan

Ang

et al. 2019

Clinical and Experimental Optometry

View full text Add to dashboard Cite

Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. An understanding of the basic principles and limitations of OCT-A technology will better inform clinicians of its future potential in the diagnosis and management of ocular diseases.

show abstract

“…Studies have shown that OCTA has the ability to quantitatively assess neovascularisation in PDR [13][14][15]. Savastano et al [14] conducted a small study of 10 eyes (6 patients) with PDR. It demonstrated that OCTA (RTVue XR Avanti) can characterise the extent of NVD with greater accuracy compared to FA [14].…”

Section: Neovascularisationmentioning

confidence: 99%

“…Savastano et al [14] conducted a small study of 10 eyes (6 patients) with PDR. It demonstrated that OCTA (RTVue XR Avanti) can characterise the extent of NVD with greater accuracy compared to FA [14]. This was due to the fact that early leakage of fluorescein during FA obscures parts of the NVD [14].…”

Section: Neovascularisationmentioning

confidence: 99%

“…It demonstrated that OCTA (RTVue XR Avanti) can characterise the extent of NVD with greater accuracy compared to FA [14]. This was due to the fact that early leakage of fluorescein during FA obscures parts of the NVD [14]. As OCTA enabled this enhanced delineation of NVD, the area (pixel 2 ) could be manually delineated by observers [14].…”

Section: Neovascularisationmentioning

confidence: 99%

See 1 more Smart Citation

The diagnostic value of optical coherence tomography angiography in diabetic retinopathy: a systematic review

Gildea

2018

Int Ophthalmol

View full text Add to dashboard Cite

Purpose Diabetic retinopathy (DR) is one of the leading causes of blindness worldwide. Accurate investigative tools are essential for the early diagnosis and monitoring of the disease. Optical coherence tomography angiography (OCTA) is a recently developed technology that enables visualisation of the retinal microvasculature. Methods A systematic review of the literature was performed to examine the diagnostic use of OCTA in DR to date. Medline, EMBASE, and Cochrane databases were searched to find relevant studies. Sixty-one original studies were selected for the review. Results and discussion OCTA has demonstrated the ability to identify microvascular features of DR such as microaneurysms, neovascularisation, and capillary non-perfusion. Furthermore, OCTA is enabling quantitative evaluation of the microvasculature of diabetic eyes. It has demonstrated the ability to detect early microvascular changes, in eyes with or without clinically evident DR. It has also been shown to detect progressive changes in the foveal avascular zone, and vascular perfusion density, with worsening severity of disease. It provides three-dimensional visualisation of the individual retinal vascular networks and is thereby enhancing our understanding of the role of the deeper vasculature in the pathogenesis of diabetic retinopathy and maculopathy. Conclusion However, limitations exist with current OCTA technology, in respect to the small field of view, image quality, projection artefact, and inaccuracies in analysis of the deeper vascular layers. While questions remain regarding its practical applicability in its present form, with continuing development and improvement of the technology, the diagnostic value of OCTA in diabetic retinopathy is likely to become evident.

show abstract

Detecting papillary neovascularization in proliferative diabetic retinopathy using optical coherence tomography angiography

Cited by 36 publications

References 7 publications

OCT angiography and visible-light OCT in diabetic retinopathy

OCT angiography and visible-light OCT in diabetic retinopathy

Future clinical applicability of optical coherence tomography angiography

The diagnostic value of optical coherence tomography angiography in diabetic retinopathy: a systematic review

Contact Info

Product

Resources

About