Detecting Progression of Retinitis Pigmentosa Using the Binomial Pointwise Linear Regression Method

Asano, Shotaro; Oishi, Akio; Asaoka, Ryo; Fujino, Yuri; Murata, Hiroshi; Azuma, Keiko; Miyata, Manabu; Obata, Ryo; Inoue, Tatsuya

doi:10.1167/tvst.10.13.15

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Inclusion criteria were: (1) typical fundus findings of RP, such as bone spicule pigmentation, arteriolar attenuation, and waxy disc pallor; (2) reduction in a-wave and b-wave amplitudes or non-detectable full-field electroretinogram; (3) absence of diseases of the anterior and posterior segments of the eye other than RP that could affect VF with slit-lamp examination, intraocular pressure measurement, and funduscopy, including cataract, except for clinically insignificant cataract, and; (4) patient age �20 years. Patients who underwent intraocular surgery, including cataract surgery, during the observation period were excluded [18]. VF measurements were performed using HFA with the 10-2 program and the Swedish Interactive Threshold Algorithm standard.…”

Section: Patientsmentioning

confidence: 99%

Investigating the clinical validity of the guided progression analysis definition with 10–2 visual field in retinitis pigmentosa

Asano,

Asaoka,

Oishi

et al. 2023

PLoS ONE

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Purpose To investigate the clinical validity of the Guided Progression Analysis definition (GPAD) and cluster-based definition (CBD) with the Humphrey Field Analyzer (HFA) 10–2 test in retinitis pigmentosa (RP). Methods Ten non-progressive RP visual fields (VFs) (HFA 10–2 test) were simulated for each of 10 VFs of 111 eyes (10 simulations × 10 VF sequencies × 111 eyes = 111,000 VFs; Dataset 1). Using these simulated VFs, the specificity of GPAD for the detection of progression was determined. Using this dataset, similar analyses were conducted for the CBD, in which the HFA 10–2 test was divided into four quadrants. Subsequently, the Hybrid Definition was designed by combining the GPAD and CBD; various conditions of the GPAD and CBD were altered to approach a specificity of 95.0%. Subsequently, actual HFA 10–2 tests of 116 RP eyes (10 VFs each) were collected (Dataset 2), and true positive rate, true negative rate, false positive rate, and the time required to detect VF progression were evaluated and compared across the GPAD, CBD, and Hybrid Definition. Results Specificity values were 95.4% and 98.5% for GPAD and CBD, respectively. There were no significant differences in true positive rate, true negative rate, and false positive rate between the GPAD, CBD, and Hybrid Definition. The GPAD and Hybrid Definition detected progression significantly earlier than the CBD (at 4.5, 5.0, and 4.5 years, respectively). Conclusions The GPAD and the optimized Hybrid Definition exhibited similar ability for the detection of progression, with the specificity reaching 95.4%.

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Section: Patientsmentioning

confidence: 99%

Investigating the clinical validity of the guided progression analysis definition with 10–2 visual field in retinitis pigmentosa

Asano,

Asaoka,

Oishi

et al. 2023

PLoS ONE

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“…Therefore, functional testing is required to solve the shortage of morphological tests. Routine perimetry examination is practical for peripheral retina or optic neuropathy, e.g., glaucoma ( 1 ) and retinitis pigmentosa ( 2 ). Nevertheless, in the macular function assessment, the standard perimetry test shows the limitations of high test–retest variability ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Trends in research related to ophthalmic microperimetry from 1992 to 2022: A bibliometric analysis and knowledge graph study

Ming

Qin

2023

Front. Med.

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BackgroundMicroperimetry is a novel technology to assess macular function. The aim of the study was to explore the global research status and trends in microperimetry.MethodsDocuments related to microperimetry in ophthalmology from 1992 to 2022 were extracted from the Science Citation Index Expanded (SCI-E) database of the Web of Science Core Collection (WOSCC). Raw data were analyzed using the VOSviewer and CiteSpace software. Bibliometric parameters included annual publication quantity, countries, authors, journals, international cooperation, and keywords.ResultsA total of 1,217 peer-reviewed documents were retrieved. Annual research output has increased significantly since 2005, especially since 2013. Holz F, Rubin G, and Guymer R contributed most to the number of articles published about microperimetry. Rubin G, Fitzke F, and Holz F, respectively, received the most citations for their study. The countries publishing most were the USA, Italy, and the UK, while the USA, the UK, and Germany received the most citation frequency. Univ Bonn, UCL, and Moorfields Eye Hosp were the top three productive institutions for microperimetry research in the world. The top three journals that publish articles about microperimetry were Retina-The Journal of Retinal and Vitreous Diseases, Investigative Ophthalmology and Visual Science, and the American Journal of Ophthalmology. The top 10 common keywords included microperimetry, optical coherence tomography, eye, retinal sensitivity, macular degeneration, fundus autofluorescence, scanning laser ophthalmoscope, visual acuity, sensitivity, and degeneration. Keywords “optical coherence tomography angiography,” “retinitis pigmentosa,” and “internal limiting membrane” burst in the last 3 years.ConclusionThe bibliometric and knowledge graph analysis of research status and trends in microperimetry provided global researchers with valuable information to propose future cooperation and track cutting-edge progress.

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Detecting Progression of Retinitis Pigmentosa Using the Binomial Pointwise Linear Regression Method

Cited by 2 publications

References 48 publications

Investigating the clinical validity of the guided progression analysis definition with 10–2 visual field in retinitis pigmentosa

Investigating the clinical validity of the guided progression analysis definition with 10–2 visual field in retinitis pigmentosa

Trends in research related to ophthalmic microperimetry from 1992 to 2022: A bibliometric analysis and knowledge graph study

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