Detecting Streptococcus suis by nanopore sequencing in endophthalmitis: A case report

Abstract

Endophthalmitis is a rare and infectious disease caused by Streptococcus suis (S suis). Traditionally, S suis is detected by the pathogenic microorganism culture method, which has low positivity and high false negativity. Nanopore sequencing (NS), which is a third-generation sequencing technology, has several advantages over the traditional method; in particular, it is cost and time effective and has a high throughput. In this report, a case of infectious endophthalmitis caused by trauma is examined. The NS results suggest that the pathogen in question is a mixed infection caused by S suis and Clostridium perfringens. This case report provides evidence of the fact that NS can quickly identify pathogens, which is of great significance for clinical diagnosis and treatment.

Streptococcus Suis Endogenous Endophthalmitis in a Patient With Meningitis

“…Streptococcus suis is traditionally detected by the pathogenic microorganism culture method; however, this method is unreliable because of the high number of false negatives. Recently, a case report by Wang et al 6 presented detecting S. suis by nanopore sequencing in posttraumatic endophthalmitis, which has several advantages over the traditional method. Interestingly, our case report indicated that iris necrosis might be an important sign of ophthalmic complication due to S. suis .…”