Detection and characterization of a human G9P[4] rotavirus strain in Japan

Yamamoto, Seiji; Kaida, Atsushi; Ono, Atsushi; Kubo, Hideyuki; Iritani, Nobuhiro

doi:10.1002/jmv.24121

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…Regarding the variation in the prevalence of some uncommon genotypes (e.g., G9P[4] G9P[6], G3P[4], G3P[6]) detected after vaccine introduction in Mozambique, it is important to mention that a number of studies in Africa [ 16 , 25 , 32 ] and Asia (India and Japan) also reported these uncommon genotypes before vaccine introduction in low frequency [ 33 , 34 ]. These uncommon genotypes, apart from G9P[6], were also observed in Ireland before vaccine introduction [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (Rotarix®) Introduction in Mozambique, 2012–2019: Emergence of Genotypes G3P[4] and G3P[8]

et al. 2020

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Group A rotavirus (RVA) remains the most important etiological agent associated with severe acute diarrhea in children. Rotarix® monovalent vaccine was introduced into Mozambique’s Expanded Program on Immunization in September 2015. In the present study, we report the diversity and prevalence of rotavirus genotypes, pre- (2012–2015) and post-vaccine (2016–2019) introduction in Mozambique, among diarrheic children less than five years of age. Genotyping data were analyzed for five sentinel sites for the periods indicated. The primary sentinel site, Mavalane General Hospital (HGM), was analyzed for the period 2012–2019, and for all five sites (country-wide analyses), 2015–2019. During the pre-vaccine period, G9P[8] was the most predominant genotype for both HGM (28.5%) and the country-wide analysis (46.0%). However, in the post-vaccine period, G9P[8] was significantly reduced. Instead, G3P[8] was the most common genotype at HGM, while G1P[8] predominated country-wide. Genotypes G9P[4] and G9P[6] were detected for the first time, and the emergence of G3P[8] and G3P[4] genotypes were observed during the post-vaccine period. The distribution and prevalence of rotavirus genotypes were distinct in pre- and post-vaccination periods, while uncommon genotypes were also detected in the post-vaccine period. These observations support the need for continued country-wide surveillance to monitor changes in strain diversity, due to possible vaccine pressure, and consequently, the effect on vaccine effectiveness.

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (Rotarix®) Introduction in Mozambique, 2012–2019: Emergence of Genotypes G3P[4] and G3P[8]

et al. 2020

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“…Recently, surveillance studies conducted on RVAs reported a high prevalence of unusual G9P [4] rotavirus strains in many countries, such as Japan, Bangladesh, Paraguay and the Republic of Korea, and also including India [23,28,34,35]. Up to 2014, only two studies reported whole-genome analysis of G9P [4] RVA strains from countries such as Japan and the USA [36,37]. Subsequently, full-genome analysis of G9P [4] strains was also reported from eastern and western parts of India and Italy [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Rotavirus G9P[4], G9P[6] and G1P[6] strains isolated from children with acute gastroenteritis in Pune, western India, 2013–2015: evidence for recombination in genes encoding VP3, VP4 and NSP1

Tatte

Maran

Walimbe

et al. 2019

Journal of General Virology

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Species A rotaviruses (RVAs) are genetically diverse pathogens. These are the most evolutionarily adaptable organisms, with a multitude of mechanisms for evolutionary change. To date, full-genome classification has been proved to be an excellent tool for studying the evolution of unusual rotavirus strains. As limited data are available from Pune (Maharashtra), western India, the current study was undertaken with the aim of understanding the genetic diversity in three (G1P[6], G9P[4] and G9P[4]) unusual RVA strains circulating in Pune, India during 2013–2015. Full-genome analysis of these strains classified them as G1-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1, G9-P[4]-I2-R2-C2-[M1-M2_R]-[A1-A2_R]-N2-T2-E6-H2 and G9-[P4-P6_R]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Sequencing and phylogenetic analysis of the structural and non-structural genes of these unusual RVA strains showed nucleotide/amino acid identities of 82.3–98.5 %/77.3–99.8 % and 86.6–97.6 %/89.6–97.8 % between the strains of the study. Evidence of recombination events was found within the genes encoding VP3, VP4 and NSP1, which showed a combination of genetic information for genogroup 1 [M1/P[6]/A1] and genogroup 2 [M2/P[4]/A2] strains. This study will facilitate future investigations into the molecular pathogenesis of such RVAs as the exchange of whole or partial genetic material between rotaviruses through recombination contributes directly to their diversification, adaptation and evolution.

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“…A number of rotavirus surveillances conducted in several parts of Japan revealed that the prevalence of rotavirus A in pediatric patients in Japan was highly variable, ranging from 7.7% to 63.0% [Konno et al, ; Zhou et al, , ; Kitahori et al, , ; Phan et al, 2004, 2007a,b,c; Nakagomi et al, ; Yoshinaga et al, ; Dey et al, ; Harada et al, ; Nakagomi et al, ; Nakanishi et al, ; Ito et al, ; Kamiya et al, ; Chan‐it et al, ; Kawada et al, ; Kuzuya et al, ; Thongprachum et al, ; Yoneda et al, ; Thongprachum et al, ; Yamamoto et al, ], while rotavirus C was detected sporadically within the range of 0.1–6.8% [Kuzuya et al, ; Kuzuya et al, ; Thongprachum et al, ], as shown in Table . The rotavirus A was first reported in Japan in children hospitalized with diarrhea at considerable high prevalence of 63% [Konno et al, ].…”

Section: Gastroenteritis Virusesmentioning

confidence: 99%

Epidemiology of gastroenteritis viruses in Japan: Prevalence, seasonality, and outbreak

Thongprachum

Khamrin

Maneekarn

et al. 2015

Journal of Medical Virology

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Acute gastroenteritis has been recognized as one of the most common diseases in humans and continues to be a major public health problem worldwide. Several groups of viruses have been reported as the causative agents of acute gastroenteritis, including rotavirus, norovirus, sapovirus, human astrovirus, adenovirus, and an increasing number of others which have been reported more recently. The epidemiology, prevalence, seasonality, and outbreaks of these viruses have been reviewed in a number of studies conducted in Japan over three decades. Rotavirus and norovirus were the two most common viruses detected almost equally in children under 5 years of age who were suffering from acute gastroenteritis. Like many other countries, the main rotavirus strains circulating in pediatric patients in Japan are G1P[8], G2P[4], G3P[8], and G9P[8]. Norovirus GII.4 was involved in most outbreaks in Japan and found to be associated with the emergence of new variants Sydney_2012. The classic human astrovirus, MLB, and VA clades astroviruses were also commonly found in pediatric patients with acute diarrhea. The sapovirus and adenovirus have been identified as the minor viral causative agents for acute gastroenteritis in Japan.

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Detection and characterization of a human G9P[4] rotavirus strain in Japan

Cited by 23 publications

References 39 publications

Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (Rotarix®) Introduction in Mozambique, 2012–2019: Emergence of Genotypes G3P[4] and G3P[8]

Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (Rotarix®) Introduction in Mozambique, 2012–2019: Emergence of Genotypes G3P[4] and G3P[8]

Rotavirus G9P[4], G9P[6] and G1P[6] strains isolated from children with acute gastroenteritis in Pune, western India, 2013–2015: evidence for recombination in genes encoding VP3, VP4 and NSP1

Epidemiology of gastroenteritis viruses in Japan: Prevalence, seasonality, and outbreak

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