2024
DOI: 10.21203/rs.3.rs-4418948/v1
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Detection and characterization of colorectal cancer by autofluorescence lifetime imaging: a preliminary study on surgical specimens

Alberto Ignacio Herrando,
Laura M. Fernández,
José Azevedo
et al.

Abstract: Colorectal cancer (CRC) ranks among the most prevalent malignancies worldwide, driving a quest for comprehensive characterization methods. We report a characterization of the ex vivo autofluorescence lifetime fingerprint of colorectal tissues obtained from 73 patients that underwent surgical resection. We specifically target the autofluorescence characteristics of collagens, reduced nicotine adenine (phosphate) dinucleotide (NAD(P)H), and flavins employing a fiber-based dual excitation (375 nm and 445 nm) opti… Show more

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