Detection and counting of a submicrometer particle in liquid flow by self-mixing microchip Yb:YAG laser velocimetry

Ohtomo, Takayuki; Sudo, Seiichi; Otsuka, Kenju

doi:10.1364/ao.55.007574

Cited by 17 publications

(5 citation statements)

References 25 publications

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“…The self-mixing laser Doppler velocimeter is one of the promising technologies applied in the observation and detection of the particles flowing in liquid [64,65], which has been recognized as the simplest, most cost-effective, and most self-aligned metrology. The system is shown in Figure 10 using a drained suspension including polystyrene latex standard spheres (PLS).…”

Section: Particle Sensingmentioning

confidence: 99%

Frequency-Shifted Optical Feedback Measurement Technologies Using a Solid-State Microchip Laser

et al. 2018

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Since its first application toward displacement measurements in the early-1960s, laser feedback interferometry has become a fast-developing precision measurement modality with many kinds of lasers. By employing the frequency-shifted optical feedback, microchip laser feedback interferometry has been widely researched due to its advantages of high sensitivity, simple structure, and easy alignment. More recently, the laser confocal feedback tomography has been proposed, which combines the high sensitivity of laser frequency-shifted feedback effect and the axial positioning ability of confocal microscopy. In this paper, the principles of a laser frequency-shifted optical feedback interferometer and laser confocal feedback tomography are briefly introduced. Then we describe their applications in various kinds of metrology regarding displacement measurement, vibration measurement, physical quantities measurement, imaging, profilometry, microstructure measurement, and so on. Finally, the existing challenges and promising future directions are discussed.

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Section: Particle Sensingmentioning

confidence: 99%

Frequency-Shifted Optical Feedback Measurement Technologies Using a Solid-State Microchip Laser

et al. 2018

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“…10,11 In this scheme, the laser source acts as an emitter, responder, and intrinsic amplifier simultaneously, which does rarely need optical alignment and reduces optical components required. Because of its compactness, self-collimation, and sensitivity, LHFI has been widely explored for displacement sensing, 12 particle detection, 13 confocal tomography, 14 and so on. Despite its promise, enhanced sensitivity to SPR via the LHFI is rarely reported so far.…”

Section: ■ Introductionmentioning

confidence: 99%

“…More specifically, the frequency-shifted incident light senses and then partially returns to the laser cavity, in turn resonating with the relaxation oscillation and inducing the intensity modulation of the laser; as a consequence, the modulated output of the laser can be enhanced even up to 10 6 -fold compared with the feedback one. , In this scheme, the laser source acts as an emitter, responder, and intrinsic amplifier simultaneously, which does rarely need optical alignment and reduces optical components required. Because of its compactness, self-collimation, and sensitivity, LHFI has been widely explored for displacement sensing, particle detection, confocal tomography, and so on. Despite its promise, enhanced sensitivity to SPR via the LHFI is rarely reported so far.…”

Section: Introductionmentioning

confidence: 99%

An Ultrasensitive and Universal Surface Plasmonic Biosensor for Detection of Micropollutants in Aquatic Environments

Tan

Dai

Zhou

et al. 2023

Environ. Sci. Technol.

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Simple yet ultrasensitive and accurate quantification of a variety of analytical targets by virtue of a universal sensing device holds promise to revolutionize environmental monitoring, medical diagnostics, and food safety. Here, we propose a novel optical surface plasmon resonance (SPR) system in which the frequency-shifted light of different polarizations returned the laser cavity to stimulate laser heterodyne feedback interferometry (LHFI), hence amplifying the reflectivity change caused by the refractive index (RI) variations on the gold-coated SPR chip surface. In addition, the s-polarized light was further used as the reference to compensate the noise of the LHFI-amplified SPR system, resulting in nearly 3 orders of magnitude enhancement of RI resolution (5.9 × 10–8 RIU) over the original SPR system (2.0 × 10–5 RIU). By exploiting nucleic acids, antibodies, and receptors as recognition materials, a variety of micropollutants were detected with ultralow detection limits, ranging from a toxic metal ion (Hg2+, 70 ng/L) to a group of commonly occurring biotoxin (microcystins, 3.9 ng microcystin-LR/L) and a class of environmental endocrine disruptors (estrogens, 0.7 ng 17β-estradiol/L). This sensing platform exhibits several distinct characteristics, including dual improvement of sensitivity and stability and common-path optical construction without needing optical alignment, demonstrating a promising avenue toward environmental monitoring.

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“…8,9 In this scheme, the laser source acts as an emitter, responder, and intrinsic amplifier simultaneously, which does rarely need optical alignment and reduces the required optical components. Because of its compactness, self-collimation, and sensitivity, LHFI has been widely explored for displacement sensing, 10 particle detection, 11 confocal tomography, 12 and so on. Despite its promise, enhanced sensitivity to SPR via LHFI is rarely reported so far.…”

Section: ■ Introductionmentioning

confidence: 99%

“…More specifically, the frequency-shifted incident light senses and then partially returns to the laser cavity, in turn resonating with the relaxation oscillation and inducing the intensity modulation of the laser; as a consequence, the modulated output of the laser can be enhanced even up to 10 6 -fold compared with the feedback one. , In this scheme, the laser source acts as an emitter, responder, and intrinsic amplifier simultaneously, which does rarely need optical alignment and reduces the required optical components. Because of its compactness, self-collimation, and sensitivity, LHFI has been widely explored for displacement sensing, particle detection, confocal tomography, and so on. Despite its promise, enhanced sensitivity to SPR via LHFI is rarely reported so far.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Screening of Endocrine-Disrupting Chemicals Using a Surface Plasmon Resonance Biosensor with Polarization-Compensated Laser Heterodyne Feedback

et al. 2023

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Developing an ultrasensitive and reliable device for continuous monitoring of various endocrine-disrupting chemicals (EDCs) is in high demand, yet it remains a significant challenge. Traditional label-free surface plasmon resonance (SPR) sensing relies on the interaction of the surface plasmon wave and the sensing liquid via intensity modulation, endowed with simple structure and easy-to-miniaturization, however suffering from inferior sensitivity and stability. Here, we propose a novel optical structure in which the frequency-shifted light of different polarization returned to the laser cavity to stimulate laser heterodyne feedback interferometry (LHFI), hence amplifying the reflectivity change caused by the refractive index (RI) variations on the gold-coated SPR chip surface, and the s-polarized light could be further used as a reference to compensate for the noise of the LHFI-amplified SPR system, resulting in nearly three orders of magnitude enhancement of the RI sensing resolution (5.9 × 10 −8 RIU) compared to the original SPR system (2.0 × 10 −5 RIU). To further boost intense signal enhancement, customdesigned gold nanorods (AuNRs), which were optimized by the finite-difference time-domain (FDTD) simulation, were used to generate localized surface plasmon resonance (LSPR). By exploiting the estrogen receptor as the recognition material, estrogenic active chemicals were detected with a 17β-estradiol/L detection limit of 0.004 ng, which is nearly 180-fold lower than that of the system without introducing AuNRs. The developed SPR biosensor is expected to be capable of screening various EDCs with universality by using several nuclear receptors, such as the androgen receptor and thyroid receptor, and will substantially accelerate the assessment of global EDCs.

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Detection and counting of a submicrometer particle in liquid flow by self-mixing microchip Yb:YAG laser velocimetry

Cited by 17 publications

References 25 publications

Frequency-Shifted Optical Feedback Measurement Technologies Using a Solid-State Microchip Laser

Frequency-Shifted Optical Feedback Measurement Technologies Using a Solid-State Microchip Laser

An Ultrasensitive and Universal Surface Plasmonic Biosensor for Detection of Micropollutants in Aquatic Environments

Ultrasensitive Screening of Endocrine-Disrupting Chemicals Using a Surface Plasmon Resonance Biosensor with Polarization-Compensated Laser Heterodyne Feedback

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