Detection and fine mapping of quantitative trait loci for bone traits on chicken chromosome one

Zhang, H.; Zhang, Y.D.; Wang, S.Z.; Liu, X.F.; Zhang, Q.; Tang, Zhijie; Li, H.

doi:10.1111/j.1439-0388.2010.00871.x

Cited by 20 publications

(22 citation statements)

References 27 publications

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“…2008) and the QTL was located near the microsatellite marker ADL328. The QTL for BW from 4 to 12 weeks of age and CW at 12 weeks of age was the same as the QTL for bone traits, including metatarsus length (MeL) and metatarsus circumference (MeC) at 4, 6, 8, 10 and 12 weeks of age and keel length (KeL) and metatarsus claw weight (MeCW) at 12 weeks of age, that was reported by Zhang et al. (2010) using the same F 2 population.…”

Section: Introductionmentioning

confidence: 54%

“…A QTL with pleiotropic effects on BW and bone traits was mapped and fine‐mapped near the marker ADL328 (Liu et al. 2007, 2008; Zhang et al. 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The Northeast Agricultural University Resource Population (NEAURP) was used in the current study (Liu et al. 2007, 2008; Zhang et al. 2010).…”

Section: Methodsmentioning

confidence: 99%

“…The traits analysed in the current study included BW from 4 to 12 weeks of age and CW at 12 weeks of age and 12 bone traits (MeL and MeC at 4, 6, 8, 10 and 12 weeks of age and KeL and MeCW at 12 weeks of age) had been fine‐mapped previously (Liu et al. 2008; Zhang et al. 2010).…”

Section: Methodsmentioning

confidence: 99%

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Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Zhang

Liu

Zhang

et al. 2011

Journal of Animal Breeding and Genetics

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Previously, a quantitative trait locus (QTL) that affects body weight (BW) at 4-12 weeks of age and carcass weight at 12 weeks of age had been mapped on chicken chromosome 1. After including more markers and individuals, the confidence interval was narrowed down to approximately 5.5 Mbps and located this QTL near a microsatellite marker (ADL328). This QTL is the same as the QTL for 12 bone traits, including metatarsus length and metatarsus circumference at 4, 6, 8, 10 and 12 weeks of age and keel length and metatarsus claw weight at 12 weeks of age, that was identified using the same population. In the current study, 1010 individuals from the Northeast Agricultural University F(2) resource population were used and 14 single-nucleotide polymorphism (SNPs) around ADL328 were developed to construct haplotypes, and an association analysis was performed to fine-map the QTL. The haplotypes were constructed on the basis of a sliding 'window', with three SNP markers included in each 'window'. The association analysis results indicated that the haplotypes in 'windows' 6-12 were significantly associated with BW and bone traits and suggested that the QTL for BW and bone traits was located between SNP8 and SNP14 or was in linkage disequilibrium with this region. The interval from SNP8 to SNP14 was approximately 400 kbps. This region contained five RefSeq genes (RB1, P2RY5, FNDC3A, MLNR and CAB39L) on the University of California Santa Cruz website. The RB1 gene was selected as a candidate gene and five SNPs were identified in the gene. The association results indicated that the RB1 gene was a major gene for BW and bone traits. The SNPs g.39692 G>A and g.77260 A>G in RB1 gene might be two quantitative trait nucleotides for BW and bone traits.

show abstract

Section: Introductionmentioning

confidence: 54%

“…A QTL with pleiotropic effects on BW and bone traits was mapped and fine‐mapped near the marker ADL328 (Liu et al. 2007, 2008; Zhang et al. 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The Northeast Agricultural University Resource Population (NEAURP) was used in the current study (Liu et al. 2007, 2008; Zhang et al. 2010).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Zhang

Liu

Zhang

et al. 2011

Journal of Animal Breeding and Genetics

Self Cite

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“…Zhang et al (2010) studied bone traits and identified 12 QTL between LEI0079 and ROS0025 markers on GGA1. In the current study, we mapped a QTL region for tibia width and weight between the LEI0079 and MCW145 markers on GGA1.…”

Section: Quantitative Trait Loci Mappingmentioning

confidence: 99%

Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers

Ragognetti¹,

Stafuzza²,

Silva³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Selection among broilers for performance traits is resulting in locomotion problems and bone disorders, once skeletal structure is not strong enough to support body weight in broilers with high growth rates. In this study, genetic parameters were estimated for body weight at 42 days of age (BW42), and tibia traits (length, width, and weight) in a population of broiler chickens. Quantitative trait loci (QTL) were identified for tibia traits to expand our knowledge of the genetic architecture of the broiler population. Genetic correlations ranged from 0.56 ± 0.18 (between tibia length and BW42) to 0.89 ± 0.06 (between tibia width and weight), suggesting that these traits are either controlled by pleiotropic genes or by genes that are in linkage disequilibrium. For QTL mapping, the genome was scanned with 127 microsatellites, representing a coverage of 2630 cM. Eight QTL were mapped on Gallus gallus chromosomes (GGA): GGA1, GGA4, GGA6, GGA13, and GGA24. The QTL regions for tibia length and weight were mapped on GGA1, between LEI0079 and MCW145 markers. The gene 17545 Genetic parameters and QTL mapping in broilers ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17544-17554 (2015) DACH1 is located in this region; this gene acts to form the apical ectodermal ridge, responsible for limb development. Body weight at 42 days of age was included in the model as a covariate for selection effect of bone traits. Two QTL were found for tibia weight on GGA2 and GGA4, and one for tibia width on GGA3. Information originating from these QTL will assist in the search for candidate genes for these bone traits in future studies.

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A combination of genome-wide association study and selection signature analysis dissects the genetic architecture underlying bone traits in chickens

Liu

et al. 2021

Animal

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Detection and fine mapping of quantitative trait loci for bone traits on chicken chromosome one

Cited by 20 publications

References 27 publications

Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers

A combination of genome-wide association study and selection signature analysis dissects the genetic architecture underlying bone traits in chickens

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