Detection and Prediction of Active Tuberculosis Disease by a Whole‐Blood Interferon‐γ Release Assay in HIV‐1–Infected Individuals

Aichelburg, Maximilian C.; Rieger, Armin; Breitenecker, F; Pfistershammer, Katharina; Tittes, Julia; Eltz, Stephanie; Aichelburg, Alexander; Stingl, Georg; Makristathis, Athanasios; Kohrgruber, Norbert

doi:10.1086/597351

Cited by 157 publications

(174 citation statements)

References 33 publications

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“…Furthermore, evidence on the actual predictive value of the IGRAs (i.e. the relationship between having a positive or negative IGRA result and developing or not developing tuberculosis) is emerging [19][20][21][22]. To further support public health programmes, a continuous assessment of the use of IGRA for the diagnosis of LTBI is, therefore, needed.…”

Section: Mprovement Of Diagnostic Methods For Latentmentioning

confidence: 99%

“…In the majority of the evaluated studies, it was not possible to compare the NPV estimates for IGRAs to that of the TST results [19,21,22,45,46]. In particular, in two studies performed on HIV-infected persons, TST-negative individuals were excluded from the follow-up [19,22].…”

Section: Npv For Progressionmentioning

confidence: 99%

“…In particular, in two studies performed on HIV-infected persons, TST-negative individuals were excluded from the follow-up [19,22]. Only one study performed a comprehensive follow-up that included TST and IGRA scorednegative subjects [20].…”

Section: Npv For Progressionmentioning

confidence: 99%

“…AICHELBURG et al [19] enrolled 830 HIV-infected individuals in an extensive LTBI screening study. Among the study group, 36 were QFT-G-IT-positive, subsequently diagnosed with LTBI and followed for a mean period of 19 months without receiving preventive treatment.…”

Section: Ppv For Progressionmentioning

confidence: 99%

See 3 more Smart Citations

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection: a systematic review and meta-analysis

Diel¹,

Goletti²,

Ferrara³

et al. 2010

Eur Respir J

492

315

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We conducted a systematic review and meta-analysis to compare the accuracy of the QuantiFERON-TB1 Gold In-Tube (QFT-G-IT) and the T-SPOT1.TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI).The Medline, Embase and Cochrane databases were explored for relevant articles in November 2009. Specificities, and negative (NPV) and positive (PPV) predictive values of interferon-c release assays (IGRAs) and the TST, and the exposure gradient influences on test results among bacille Calmette-Guérin (BCG) vaccinees were evaluated.Specificity of IGRAs varied 98-100%. In immunocompetent adults, NPV for progression to tuberculosis within 2 yrs were 97.8% for T-SPOT1.TB and 99.8% for QFT-G-IT. When test performance of an immunodiagnostic test was not restricted to prior positivity of another test, progression rates to tuberculosis among IGRA-positive individuals followed for 19-24 months varied 8-15%, exceeding those reported for the TST (2-3%). In multivariate analyses, the odd ratios for TST positivity following BCG vaccination varied 3-25, whereas IGRA results remained uninfluenced and IGRA positivity was clearly associated with exposure to contagious tuberculosis cases.IGRAs may have a relative advantage over the TST in detecting LTBI and allow the exclusion of M. tuberculosis infection with higher reliability.

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Section: Mprovement Of Diagnostic Methods For Latentmentioning

confidence: 99%

Section: Npv For Progressionmentioning

confidence: 99%

Section: Npv For Progressionmentioning

confidence: 99%

Section: Ppv For Progressionmentioning

confidence: 99%

See 2 more Smart Citations

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection: a systematic review and meta-analysis

Diel¹,

Goletti²,

Ferrara³

et al. 2010

Eur Respir J

492

315

View full text Add to dashboard Cite

show abstract

“…In countries of low-to-medium tuberculosis prevalence, shortterm progression rates to tuberculosis in individuals belonging to tuberculosis risk groups have been reported to range from 3.3% to 12.9% [5][6][7][8][9]. Although the potential cost-effectiveness of an IGRA for the investigation of LTBI has recently been demonstrated in immigrant screening in the UK [10], information on the predictive values of IGRAs for the development of tuberculosis still relies on a small number of at-risk individuals who actually developed tuberculosis.…”

Section: From the Authorsmentioning

confidence: 99%

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection

et al. 2011

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Interferon‐γ release assay versus tuberculin skin test prior to treatment with golimumab, a human anti–tumor necrosis factor antibody, in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis

Hsia

Schluger

Cush

et al. 2012

Arthritis & Rheumatism

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Objective. To evaluate the performance of an interferon-␥ release assay (IGRA) versus the standard tuberculin skin test (TST) as a screening tool for latent tuberculosis (TB) infection prior to the initiation of anti-tumor necrosis factor therapy in patients with autoimmune inflammatory diseases.Methods. This integrated analysis involved screening of patients with rheumatoid arthritis, those with psoriatic arthritis, and those with ankylosing spondylitis from phase III trials of golimumab. The IGRA used to screen for latent TB was the QuantiFERON-TB Gold In-Tube test.Results. In this pooled analysis, 2,282 patients underwent both IGRA and TST screening prior to golimumab treatment. Among these patients, 13.8% had at least one test yielding positive findings for latent TB, including 9. 0% (62 of 1,248) and the rate of positivity by IGRA was 5.8% (72 of 1,248) (P ‫؍‬ 0.3745). When the IGRA was repeated in patients whose results were initially indeterminate, the rate of indeterminate IGRA findings for latent TB was much lower than has been previously reported.Conclusion. In the absence of a true gold standard test for latent TB infection, results of this comparison of IGRA and TST in a large cohort of patients with rheumatic diseases suggest that the IGRA provides greater specificity and possibly greater sensitivity than the TST.Screening for latent tuberculosis (TB) infection prior to use of tumor necrosis factor (TNF) antagonists

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Detection and Prediction of Active Tuberculosis Disease by a Whole‐Blood Interferon‐γ Release Assay in HIV‐1–Infected Individuals

Abstract: Our results suggest that the QFT-GIT assay may be a sensitive tool for the detection and prediction of active tuberculosis in HIV-1-infected individuals.

Cited by 157 publications

References 33 publications

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection: a systematic review and meta-analysis

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection: a systematic review and meta-analysis

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection

Interferon‐γ release assay versus tuberculin skin test prior to treatment with golimumab, a human anti–tumor necrosis factor antibody, in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis

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