Detection and Prognostic Value of Cytokeratin Positive Tumor Cells in Bone Marrow of Patients With Renal Cell Carcinoma

Büchner, Alexander; Riesenberg, Rainer; Kotter, Ines; Crispin, Alexander; Hofstetter, A.; Oberneder, R.

doi:10.1097/01.ju.0000091877.49439.cf

Cited by 7 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one series of 139 patients, bone marrow status was a strong predictor for both tumor relapse and tumor-associated death, which could also be confirmed by multivariate analysis [28,93]. Further prospective clinical trials have underlined the relevance of ITCs in bone marrow as a predictor of poor prognosis and reduced OS in various other epithelial tumor entities, including head and neck [94][95][96], prostate [97][98][99][100][101], pancreatic [102][103][104][105], and renal and bladder [106,107] cancers, and neuroblastoma [108][109][110][111][112][113][114].…”

Section: Mrd In Solid Tumorsmentioning

confidence: 92%

Detection of Micrometastatic Disease in Bone Marrow: Is It Ready for Prime Time?

et al. 2005

View full text Add to dashboard Cite

show abstract

Section: Mrd In Solid Tumorsmentioning

confidence: 92%

Detection of Micrometastatic Disease in Bone Marrow: Is It Ready for Prime Time?

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In addition, one study on bone marrow samples detected disseminated tumor cells in 25% of renal cell carcinoma patients (27). At the follow-up (median, 40 months) 14% of patients with CK+ disseminated tumor cells in their bone marrow suffered from tumor progression in contrast to 11% of patients without CK+ disseminated tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Renal Cell Carcinoma Correlates with Prognosis

Bluemke

Bilkenroth

Meye

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Purpose: The aim of this study was to evaluate the clinical relevance of the presence of disseminated tumor cells in peripheral blood (so-called circulating tumor cells) for renal cell carcinoma patients. Methods: Two hundred thirty-three peripheral blood samples from 154 renal cell carcinoma patients were investigated for the presence of disseminated tumor cells by autoMACS technique and immunocytochemical staining of cytokeratin. The frequency of circulating tumor cells was analyzed statistically for correlation with relevant clinical data. Results: Two kinds of tumor cells were detected: those with expression of cytokeratin 8/18 (CK+) and cells without a detectable cytokeratin expression, which we called large blue-stained cells with a tumorlike morphology. After following the CD45 autoMACS depletion protocol, we identified circulating tumor cells in 96 (41%) of 233 peripheral blood samples, which originated from 81 (53%) of 154 renal cell carcinoma patients.A significant correlation between the detection of circulating tumor cells and positive lymph node status (P < 0.001; χ 2 test) and the presence of synchronous metastases at the time of primary tumor resection (P = 0.014; χ 2 test) was found. In a multivariate Cox's regression hazard model, presence of CK+ circulating tumor cells was significantly correlated with poor overall survival for renal cell carcinoma patients (relative risk, 2.3; P = 0.048). Conclusions:The presence of circulating tumor cells correlated to lymph node status and presence of synchronous metastases in renal cell carcinoma. It is important to evaluate CK+ and blue-stained tumor cells together to determine the role of circulating tumor cells in tumor behavior and disease progression. Detection of CK+ circulating tumor cells in peripheral blood is a significant and independent prognostic factor for renal cell carcinoma. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2190-4)

show abstract

“…In one study conducted with non-metastatic RCC patients, no prognostic relevance was found for disseminated cytokeratin-positive (CK+) cells in the bone marrow [54]. However, in another study, Buchner et al [50] found the prognostic values of disseminated CK+ cells in the bone marrow of patients with metastatic RCC indicated that these cells played an important role in tumour spread in metastatic RCC.…”

Section: Introductionmentioning

confidence: 99%

Metastasis-Initiating Cells in Renal Cancer

Khan¹,

Czarnecka²,

Duchnowska³

et al. 2014

CST

View full text Add to dashboard Cite

Metastasis is a complex process that propagates cells from the primary or initial site of the cancer occurrence to distant parts of the body. Cancer cells break from the cancer site and circulate through the bloodstream or lymph vessels, allowing them to reach nearly all parts of the body. These circulating tumour cells (CTCs) contain specialized metastasis-initiating cells (MICs) that reside in the biological heterogeneous primary tumour. Researchers have hypothesized that metastasis of renal cell carcinoma is initiated by circulation of MICs in patients’ blood and bone marrow. Based on the cancer stem/progenitor cell concept of carcinogenesis, understanding the molecular phenotypes of metastasis-initiating cells (MICs) in renal cancer could play a vital role in developing strategies for therapeutic interventions in renal cancer. Existence of MICs among CTCs in renal carcinoma has not been proven in large scale. However, some studies have reported that specialized markers are found on the surface of circulating cells from the primary tumour. In mice, MICs have been isolated from CTCs using such markers, which have then been transplanted into xenograft model to show whether they give rise to metastasis in different organs. Considering these findings, in this review we have attempted to summarize the studies connected with MICs and their gene expression profiles that are responsible for metastasis in renal cancer.

show abstract

Detection and Prognostic Value of Cytokeratin Positive Tumor Cells in Bone Marrow of Patients With Renal Cell Carcinoma

Abstract: These results indicate that the immunocytochemical detection of disseminated cytokeratin positive tumor cells in the bone marrow of patients with RCC has no prognostic significance.

Cited by 7 publications

References 18 publications

Detection of Micrometastatic Disease in Bone Marrow: Is It Ready for Prime Time?

Detection of Micrometastatic Disease in Bone Marrow: Is It Ready for Prime Time?

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Renal Cell Carcinoma Correlates with Prognosis

Metastasis-Initiating Cells in Renal Cancer

Contact Info

Product

Resources

About