Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma

Neves, A.; Thompson, Gertrude; Carvalheira, J.; Trindade, José Costa; Rueff, José; Caetano, Joaquim Machado; Casey, James W.; Hermouet, Sylvie

doi:10.1016/j.brainres.2008.05.009

Cited by 28 publications

(22 citation statements)

References 52 publications

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“…Moreover, VZV DNA was detected in two out of 35 pilocytic astrocytoma by Neves et al (46). None of the samples in the present study were positive for VZV DNA.…”

Section: Discussioncontrasting

confidence: 51%

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Strojnik

Duh

Lah

2017

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“…Moreover, VZV DNA was detected in two out of 35 pilocytic astrocytoma by Neves et al (46). None of the samples in the present study were positive for VZV DNA.…”

Section: Discussioncontrasting

confidence: 51%

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Strojnik

Duh

Lah

2017

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“…HHV-6 infection may be associated with the nodular sclerosing (NS)-type Hodgkin lymphoma and angioimmunoblastic T cell lymphoma (AITL). In addition, recent studies from our group and others demonstrated that HHV-6 may also be associated with glioma (5)(6)(7)(8).…”

mentioning

confidence: 70%

Development of Virus-Specific CD4 ⁺ and CD8 ⁺ Regulatory T Cells Induced by Human Herpesvirus 6 Infection

Wang

Chi

Peng

et al. 2014

J Virol

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؉ effector T cell immune responses but also could impair dendritic cell (DC) maturation and functions. In addition, the suppressive effects mediated by HHV-6-specific Treg cells were mainly through a cell-to-cell contact-dependent mechanism but not through the identified cytokines. These results suggest that HHV-6 may utilize the induction of Treg cells as a strategy to escape antivirus immune responses and maintain the latency and immunosuppression in infected hosts.

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“…Virtually all neurons, ependymal cells, choroid plexus epithelial cells, meningothelial cells, vascular endothelial cells, as well as many oligodendrocytes, astrocytes, and vascular smooth muscle cells express nectin-1 [149–152], However, reports on the presence of HSV-1 DNA in brain tumors are contradictory [123, 153, 154]. This may be explained both by the differences in the sensitivity of the used techniques and by the presence of only the fragments of the viral DNA.…”

Section: Hsv-1 and -2mentioning

confidence: 99%

“…EBV was detected in a significant number of samples obtained from patients with pilocytic astrocytoma, a non-malignant glioma [123]. However, EBV, which is known for its link with primary brain lymphomas [225, 226], has not been associated with malignant gliomas before.…”

Section: Other Herpesvirusesmentioning

confidence: 99%

The roles of viruses in brain tumor initiation and oncomodulation

et al. 2011

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While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

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Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma

Cited by 28 publications

References 52 publications

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Development of Virus-Specific CD4 ⁺ and CD8 ⁺ Regulatory T Cells Induced by Human Herpesvirus 6 Infection

The roles of viruses in brain tumor initiation and oncomodulation

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Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma

Cited by 28 publications

References 52 publications

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential

Development of Virus-Specific CD4 + and CD8 + Regulatory T Cells Induced by Human Herpesvirus 6 Infection

The roles of viruses in brain tumor initiation and oncomodulation

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Product

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Development of Virus-Specific CD4 ⁺ and CD8 ⁺ Regulatory T Cells Induced by Human Herpesvirus 6 Infection