Detection and quantitative estimation of metalloporphyrins in vivo

Nakajima, Susumu; Sakata, Isao; Omote, Yoshiharu; Yamazaki, Kosuke; Maeda, T.; Kubo, Yoshihiro; Samejima, Natsuki; Takemura, Tamiko; Shindo, Yasunori; Yamauchi, Hirohiko; Koshimįzu, Koichi

doi:10.1016/1011-1344(91)80115-x

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…Regarding the distribution of HpD in the liver, its HpD level showed a second increase on day 7. A similar tendency was also noted in the previous reports [15][16][17][18][19]20]. This suggests that HpD was excreted into the intestine as bile, which was reabsorbed from the intestine.…”

supporting

confidence: 74%

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Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Okamoto

Yonemura

Miyatake

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. We evaluated changes in hematology and chemical profile, and the tissue retention of hematoporphyrin derivative (HpD) following the intravenous injection in dogs. HpD at concentrations of 1, 5, 10, and 15 mg/kg was intravenously injected to 16 dogs (n=4 each) and complete blood count (CBC) and blood chemistry were performed on days 1, 3, 5, and 7 after the injection. To examine tissue retention, HpD (5 mg/kg) was administered to 15 dogs and 3 dogs were euthanized on days 1, 2, 7, 14, and 28 after the injection, respectively, to collect the skin, muscle, small intestine, spleen, kidney and liver as tissue samples. There were no significant cha nges in CBC and blood chemical profile except for an increase in LDH concentrations in dogs given 10 and 15 mg/kg of HpD at day 3. The levels of HpD retention in the tissues were ranked in the following order: liver > kidney > spleen > intestine > muscle > skin. KEY WORDS: canine, hematoporhyrin D, photodynamic therapy.

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confidence: 74%

“…In the reports of Kessel et al [10], the HpD level was measured by HPLC [10], a method using a radioactive material [7], and nitrogen-pulsed laser spectrofluorometry (N 2 -PLS) [15,16]. While N 2 -PLS has been pointed out to be less efficient in the quantitative analysis, it can be recommended for its very high simplicity.…”

mentioning

confidence: 99%

Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Okamoto

Yonemura

Miyatake

et al. 2004

The Journal of Veterinary Medical Science

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“…ATX-S10 (Na) is classified as a hydrophilic photosensitizer because it contains four carboxylates (COONa) at the periphery of the porphyrin (8). ATN-2 was synthesized from protoporphyrin dimethyl ester by a method described previously (5). ATN-2 has a molecular weight of 1102.79 and is classified as a hydrophilic metalloporphyrin.…”

Section: Methodsmentioning

confidence: 99%

“…1A) and the metalloporphyrin diethylenetriamine pentaazetic acid ester of the 2-[1-(2-hydroxyethoxy) ethyl]-4-vinyl-deuteroporphyrin (IX) Ga complex (ATN-2) (Fig. 1B), both developed by our group, have significant tumorlocalizing capacity (5,6). Moreover, because ATX-S10 (Na) exhibits a significant phototoxic effect on squamous cell carcinoma (7) and is completely eliminated from all organs except the tumor and liver 24 h after intravenous injection, the risk of cutaneous photosensitivity might be reduced, thus making it a promising drug for PDT (7).…”

Section: Introductionmentioning

confidence: 95%

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX-S10 (Na) and ATN-2, Binding with Human Serum Proteins Using Spectrophotometry¶

Yamaguchi

Tanabe

Nakajima

et al. 2004

Photochem Photobiol

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Intermolecular interactions of human serum proteins with a hydrophilic nonmetalloporphyrin, 13,17-bis(1-carboxypropionyl)carbomoylethyl-8-ethenyl-2-hydroxy-3-hydroxyiminoethylidene-2,7,12,18-tetramethylporphyrin sodium salt (ATX-S10 (Na)), or a hydrophilic gallium-metalloporphyrin, diethylenetriamine pentaacetic acid ester of 2-[1-(2-hydroxy-ethoxy)ethyl]-4-vinyl-deuteroporphyrin (IX) Ga complex (ATN-2), were investigated using spectrophotometry. ATX-S10 (Na) caused a bathochromic shift with albumin, high-density lipoprotein and low-density lipoprotein, but little or no shift was observed with hemopexin, transferrin and immunoglobulin G. In contrast, ATN-2 displayed a bathochromic shift only with hemopexin. These results suggest that the association energy of ATX-S10 (Na) with albumin might be slightly greater than that with lipoproteins and that of ATN-2 with hemopexin might be greater than that with other serum proteins.

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“…1A) and the metalloporphyrin diethylenetriamine pentaazetic acid ester of the 2‐[1‐(2‐hydroxyethoxy) ethyl]‐4‐vinyl‐deuteropophyrin (IX) Ga complex (ATN‐2) (Fig. 1B), both developed by our group, have significant tumor‐localizing capacity (5,6). Moreover, because ATX‐S10 (Na) exhibits a significant phototoxic effect on squamous cell carcinoma (7) and is completely eliminated from all organs except the tumor and liver 24 h after intravenous injection, the risk of cutaneous photosensitivity might be reduced, thus making it a promising drug for PDT (7).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX‐S10 (Na) and ATN‐2, Binding with Human Serum Proteins Using Spectrophotometry^¶

Yamaguchi

Tanabe

Nakajima

et al. 2004

Photochem & Photobiology

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Intermolecular interactions of human serum proteins with a hydrophilic nonmetalloporphyrin, 13,17‐bis(1‐carboxy‐propionyl)carbomoylethyl‐8‐ethenyl‐2‐hydroxy‐3‐hydroxy‐iminoethylidene‐2,7,12,18‐tetramethylporphyrin sodium salt (ATX‐S10 (Na)), or a hydrophilic gallium‐metalloporphyrin, diethylenetriamine pentaacetic acid ester of 2‐[1‐(2‐hydroxyethoxy)ethyl]‐4‐vinyl‐deuteroporphyrin (IX) Ga complex (ATN‐2), were investigated using spectrophotometry. ATX‐S10 (Na) caused a bathochromic shift with albumin, high‐density lipoprotein and low‐density lipoprotein, but little or no shift was observed with hemopexin, transferrin and immuno‐globulin G. In contrast, ATN‐2 displayed a bathochromic shift only with hemopexin. These results suggest that the association energy of ATX‐S10 (Na) with albumin might be slightly greater than that with lipoproteins and that of ATN‐2 with hemopexin might be greater than that with other serum proteins.

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Detection and quantitative estimation of metalloporphyrins in vivo

Cited by 15 publications

References 7 publications

Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX-S10 (Na) and ATN-2, Binding with Human Serum Proteins Using Spectrophotometry¶

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX‐S10 (Na) and ATN‐2, Binding with Human Serum Proteins Using Spectrophotometry^¶

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Detection and quantitative estimation of metalloporphyrins in vivo

Cited by 15 publications

References 7 publications

Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX-S10 (Na) and ATN-2, Binding with Human Serum Proteins Using Spectrophotometry¶

Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX‐S10 (Na) and ATN‐2, Binding with Human Serum Proteins Using Spectrophotometry¶

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Comparison of Nonmetal and Metal Hydrophilic Photosensitizer, ATX‐S10 (Na) and ATN‐2, Binding with Human Serum Proteins Using Spectrophotometry^¶