Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer’s disease dementia

Kouzuki, Minoru; Ichikawa, Junya; Shirasagi, Daiki; Katsube, Fumiya; Kobashi, Yuuki; Matsui, Hideki; Chao, Huichia; Yoshida, Shintaro; Urakami, Katsuya

doi:10.1186/s12883-020-01691-7

Cited by 28 publications

(17 citation statements)

References 52 publications

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“… 17 Little research has explored dietary changes and challenges of survivors with cancer-related fatigue specifically, but due to its prevalence among survivors, should be explored. While taste changes are common in cancer survivors, 41 they are not known to be linked with cognitive impairment 42 and likely to be a broader survivorship challenge.…”

Section: Discussionmentioning

confidence: 99%

Dietary Drivers and Challenges of Australian Breast Cancer Survivors: A Qualitative Study

Coro

Hutchinson

Banks

et al. 2022

Women's Health Reports

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Purpose: Cancer survivors often make long-term dietary changes, and nutrition is important for survivorship outcomes. Many survivors experience persisting cognitive difficulties, which can impact health behaviors. This study aimed to identify perceived drivers of eating habit changes, and the barriers to making intentional dietary changes, among breast cancer survivors with persisting self-reported cancer-related cognitive impairment. Materials and Methods: A qualitative framework explored survivors' perceptions of dietary habit changes. Thirteen Australian breast cancer survivors (M.time since diagnosis: 23.6 months, standard deviation [SD] 15.3; M.time since completing primary treatment: 14.7 months, SD 15.3) completed semistructured interviews. Questions related to dietary changes since diagnosis and treatment. Major themes were identified from interview transcripts using thematic analysis. Results: While most individuals perceived their diet to be broadly similar to prediagnosis, several changes to diet and eating habits were identified, which were often meaningful to these survivors. Themes relating to survivors' eating habit changes included the following: (1) meal timing and frequency shifts, (2) more plant-based eating, and (3) less variety and more convenience. Changes in eating habits were attributed to the following: (1) persisting treatment-related changes, (2) help and support from others, (3) old treatment habits, (4) preventative health and self-care, and (5) changes to work schedule. Barriers to making intentional dietary changes included the following: (1) too much time and effort, (2) food cravings and enjoyment, and (3) lacking dietary ideas and resources. Conclusions: Many survivors reported long-term changes in dietary habits, some of which align with current recommendations. Causes of dietary habit changes, and barriers to engaging in healthier dietary habits, involved multiple biopsychosocial elements. Additional resources or strategies that assist navigating survivorship challenges and their effects on dietary habits are needed. Future studies should explore whether post-treatment nutritional review with a qualified dietary health professional is helpful for survivors who experience long-term cancer-related cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Dietary Drivers and Challenges of Australian Breast Cancer Survivors: A Qualitative Study

Coro

Hutchinson

Banks

et al. 2022

Women's Health Reports

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“…Children with onset before the age of 7 years are found to have mild central brain atrophy and significant differences in intellectual performance in adulthood ( 27 ). Taste recognition is also thought to be associated with cognitive function, although studies have been focused on the elderly ( 28 , 29 ). Based on this evidence, we can speculate that differences in cognitive ability may also contribute to taste recognition observed in type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Altered Taste Function in Young Individuals With Type 1 Diabetes

et al. 2022

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Past studies on altered taste function in individuals with type 1 diabetes have yielded inconsistent results. We therefore evaluated taste recognition and possible association with personal and diseases characteristics in young individuals with type 1 diabetes and healthy controls. Taste recognition and intensity for 6-n-propylthiouracil (PROP), quinine, citric acid, sucrose, and sodium chloride were assessed using a filter paper method in 276 participants with type 1 diabetes and 147 healthy controls. Personal and clinical data were recorded for all participants during a baseline visit. Regression analysis was adjusted for sex, age, and standardized BMI. Overall, 47% of participants with type 1 diabetes vs. 63.5% of healthy controls recognized all tastes (p = 0.006). Moreover, a lower capacity for recognizing the bitter taste of PROP and the sour taste of citric acid was found in participants with type 1 diabetes compared to healthy controls (p = 0.014 and p = 0.003, respectively). While no significant effect of glycemic control on taste recognition was found, an association with lower age at onset emerged. Our findings suggest an impaired taste perception in individuals with type 1 diabetes, possibly linked to age at onset.

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“…On the other hand, it has been reported that age-related changes in taste function are related to alterations in the neuronal circuits [7]. In addition, some studies reported that patients with Alzheimer's disease show higher taste threshold than control subjects [8][9][10][11]. These suggest that functional changes in the central nervous system, such as cognitive function decline, may affect the age-dependent changes in taste sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that functional changes in the central nervous system may affect to taste sensitivity. Furthermore, studies have reported a decline in taste sensitivity in patients with Alzheimer's disease [8][9][10][11]. Alzheimer's disease is a syndrome caused by a number of progressive illnesses that affect cognitive capacity in adults aged 65 years and older [8].…”

Section: Introductionmentioning

confidence: 99%

Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice

et al. 2021

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Several studies have suggested that cognitive impairment affects taste sensitivity. However, the mechanism behind this is still unclear. In this study, we focused on short-term memory. Using senescence-accelerated mouse prone 1 (SAMP1) mice, we compared whether the effects of aging are observed earlier in taste sensitivity or short-term memory. We used 8-week-old mice as the young group, and 70- and 80-week-old mice as aged groups. Taste sensitivity was evaluated using a 48-hour two-bottle preference test, and short-term memory was evaluated using the Y-maze test. SAMP1 mice showed apparently changes in taste sensitivity at 70-weeks-old. However, the influence of aging on spontaneous alternation behavior, which is indicative of short-term memory alterations, was not observed in 70-week-old mice. At 80-weeks-old, the influence of aging was observed, and spontaneous alternation behavior was significantly decreased. This suggests that age-dependent changes in taste sensitivity occur prior to short-term memory function decline. In addition, there was no significant influence of aging on the mRNA expression of long-term potentiation-related genes in the hippocampus of 80-week-old mice. Therefore, the age-related decline of short-term memory may not affect taste sensitivity.

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Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer’s disease dementia

Cited by 28 publications

References 52 publications

Dietary Drivers and Challenges of Australian Breast Cancer Survivors: A Qualitative Study

Dietary Drivers and Challenges of Australian Breast Cancer Survivors: A Qualitative Study

Altered Taste Function in Young Individuals With Type 1 Diabetes

Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice

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