Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy

Abstract

PurposeThe purpose of this study was to evaluate the efficacy of narrow-band imaging (NBI) as a diagnostic tool for detecting bladder tumors during cystoscopy compared with white light cystoscopy (WLC).Materials and MethodsFrom December 2013 to June 2017, a randomized prospective study was conducted on 198 patients underwent transurethral resection of bladder tumor by a single surgeon. The patients were divided into two groups according to diagnostic method. In Group I, WLC only was performed. In Group II, NBI was additionally performed after WLC. We analyzed the rate of detection of bladder tumors as a primary endpoint. In addition, we evaluated rates of recurrence in each group.ResultsThere were no significant differences between the two groups in characteristics except hypertension. In the analysis of rates of detection, the probability of diagnosing cancer was 80.9% (114/141) in the WLC group, and the probability of diagnosing cancer using WLC in the NBI group was 85.5% (159/186). After switching from WLC to NBI for second-look cystoscopy in the NBI group, NBI was shown to detect additional tumors with a detection rate of 35.1% (13/37) from the perspective of the patients and 42.2% (27/64) from the perspective of the tumors. The 1-year recurrence-free rate was 72.2% in the WLC group and 85.2% in the NBI group (p=0.3).ConclusionsNBI had benefits for detecting tumors overlooked by WLC. Although the difference in the 1-year recurrence-free rate was not statistically significant, our results showed a trend for higher recurrence in the NBI group.

Impact of enhanced optical techniques at time of transurethral resection of bladder tumour, with or without single immediate intravesical chemotherapy, on recurrence rate of non‐muscle‐invasive bladder cancer: a systematic review and network meta‐analysis of randomized trials

“…Based on the selection criteria, we identified 22 articles comprising 4519 patients for this systematic review and network meta‐analysis [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 . Extracted data from the 22 studies are outlined in the online supplementary materials .…”

Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line

“…This therapeutic combination has undergone little changes in recent decades. In terms of surgery, there are some novelties such as en bloc resections of the tumors [ 3 ], that could be an alternative the classic transurethral resections [ 4 ] for some patients. However, in terms of intravesical therapy, the therapeutic agents in use are the same since the 1980s, such as mitomycin C and Bacillus Calmette-Guérin (BCG) [ 5 , 6 ].…”

Novel Visualization Methods Assisted Transurethral Resection for Bladder Cancer: An Updated Survival-Based Systematic Review and Meta-Analysis

“…We excluded 13 published studies. We included 20 studies (reported in 28 articles) in this review ( 19 , 26 – 52 ). A flow diagram illustrating the study selection process is shown in Figure 1 .…”

“…Narrow-band imaging (NBI) is another novel endoscopic technique applied in clinical practice. NBI enhance the contrast between the superficial mucosa and microvascular structures via only emitting two bandwidths of illumination, 415 nm (blue) and 540 nm (green) ( 18 , 19 ). Assisted by specialized cystoscopes, surgeons could notice abnormal microvasculature and perform NBI-guided TURBT without prior instillation of dyes ( 20 ).…”