Detection and removal of biologically active organic micropollutants from hospital wastewater

Meza, Luis Castillo; Piotrowski, Paulina K.; Farnan, James; Tasker, Travis L.; Xiong, Boya; Weggler, Benedikt; Dorman, Frank L.; Heuvel, John P. Vanden; Burgos, William D.

doi:10.1016/j.scitotenv.2019.134469

Cited by 30 publications

(14 citation statements)

References 33 publications

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“…Although Al Amal hospital is a psychiatric medical facility, nontargeted characterization of the wastewaters from this hospital showed that the most abundant (32%) chemical constituents are medications including antibiotics, antidepressants and antipsychotics. Meza et al detected the presence of 52 organic contaminants in Hershey Medical Center wastewater and observed 83% of the identified chemicals to be pharmaceuticals, while the rest were pharmaceutical metabolites or antifungals (Meza et al, 2020). Another study also characterized the wastewater collected from 4 general hospitals and detected 31 out of 55 (56%) identified chemicals to be pharmaceuticals.…”

Section: Discussionmentioning

confidence: 99%

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Baasher

Wang

Yusnan

et al. 2022

Front. Environ. Sci.

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This study characterizes a total of 21 wastewater samples collected from Al Amal hospital, and aims to determine if untreated hospital wastewater may impose a potentially detrimental impact on the downstream municipal biological wastewater treatment process. By means of solid phase extraction and liquid chromatography with tandem mass spectrometry (LC-MS/MS), chemical contaminants in these wastewater samples were determined in a non-targeted manner. In-silico characterization for the mutagenicity and reactive oxygen species (ROS) producing capabilities was performed by checking against database and literature. However, majority of the chemical contaminants have no prior information available and remain uncharacterized for both traits. Instead, in-vitro mutagenicity tests by means of Ames test showed that majority of the samples were non-mutagenic except for 5 samples that imposed mutagenic effect at high concentrations of >×10. In-vitro tests to determine for intracellular ROS production further showed that one of the mutagenic samples collected on Jun-22 positively induce ROS production and subsequently increased horizontal gene transfer via natural transformation. The findings in this study suggest that a specialty hospital like Al Amal does not frequently contribute mutagenic compounds and ROS to the wastewater streams, and in instances where it contributed positively, would require a high concentration to do so. Hence in general, wastewater streams from a specialty hospital like Al Amal may be unlikely to significantly perturb the downstream environment.

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Section: Discussionmentioning

confidence: 99%

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Baasher

Wang

Yusnan

et al. 2022

Front. Environ. Sci.

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“…While macro-pollutants include contaminants such as bacteria, viruses and contributors to physio-chemical aspects like chemical oxygen demand (COD), biological oxygen demand (BOD), suspended solids (SS), pH, etc. (Achak et al 2021 ; Castillo Meza et al 2020 ; Lee et al 2014 ; Luo et al 2014 ; Verlicchi et al 2010 ). Both types of pollutants are of significant concern to humans and environment.…”

Section: Hospital Wastewater Characteristicsmentioning

confidence: 99%

Strategies for safe management of hospital wastewater during the COVID-19 pandemic

Balakrishnan

Jacob²,

Kumar³

et al. 2023

Int. J. Environ. Sci. Technol.

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Management of hospital wastewater is a challenging task, particularly during the situations like coronavirus 2019 (COVID-19) pandemic. The hospital effluent streams are likely to contain many known and unknown contaminants including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) along with a variety of pollutants arising from pharmaceuticals, life-style chemicals, drugs, radioactive species, and human excreta from the patients. The effluents are a mixed bag of contaminants with some of them capable of infecting through contact. Hence, it is essential to identify appropriate treatment strategies for hospital waste streams. In this work, various pollutants emerging in the context of COVID-19 are examined. A methodical review is conducted on the occurrence and disinfection methods of SARS-CoV-2 in wastewater. An emphasis is given to the necessity of addressing the challenges of handling hospital effluents dynamically involved during the pandemic scenario to ensure human and environmental safety. A comparative evaluation of disinfection strategies makes it evident that the non-contact methods like ultraviolet irradiation, hydrogen peroxide vapor, and preventive approaches such as the usage of antimicrobial surface coating offer promise in reducing the chance of disease transmission. These methods are also highly efficient in comparison with other strategies. Chemical disinfection strategies such as chlorination may lead to further disinfection byproducts, complicating the treatment processes. An overall analysis of various disinfection methods is presented here, including developing methods such as membrane technologies, highlighting the merits and demerits of each of these processes. Finally, the wastewater surveillance adopted during the COVID-19 outbreak is discussed. Supplementary Information The online version contains supplementary material available at 10.1007/s13762-023-04803-1.

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“…Although nowadays many contaminants, such as pesticides, halogenated compounds, and polycyclic aromatic hydrocarbons, are recognized as priority pollutants regulated under environmental laws, contaminants of emerging concerns are not currently under any regulations but might be under investigation for future regulation. In such context, advanced separation methods such as GC×GC presenting enhanced peak capacity and sensitivity are preferable to monitor multi-class contaminants in diverse and complex environmental samples such as water, 71,72 wastewater, 73,74 aerosol, [75][76][77] and oil. 78,79 Meza et al used GC×GC to characterize biologically active micropollutants in hospital wastewater and to evaluate the efficiency of the wastewater treatment for such pollutants removal.…”

Section: Environmental Applicationsmentioning

confidence: 99%

“…As can be seen in Figure 8, polyalkylene glycol monoalkyl ethers were not detected anymore in the total ion chromatogram obtained from the wastewater after treatment (bottom). 73 In another study, the coupling of SBSE with GC×GC was investigated for multiclass organic contaminants characterization in wastewater. 74 Compared to classical liquid-liquid extraction, similar extraction efficiencies were obtained for influent wastewater.…”

Section: Environmental Applicationsmentioning

confidence: 99%

30^th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances

Zanella

Focant

Franchina

2021

Analytical Science Advances

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In this review, we report on the latest (2020‐Early 2021) instrumental advances and applications of comprehensive two‐dimensional gas chromatography (GC×GC), including its hyphenation with novel upstream or downstream processes (sample preparation approaches or detection technologies). We also discuss software and analysis workflow developments necessary to elaborate the dense chemical information obtained. Thirty years after its inception, the use of GC×GC, as the main analytical tool or as a complementary platform, is undoubtedly shifting toward more applied challenges in a vast breadth of applications. Therefore, we consider the major fields (energy, fuel, foodstuff, plant, biological, and environmental) in which GC×GC has been successfully used, discussing some of the recent innovative research works.

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Detection and removal of biologically active organic micropollutants from hospital wastewater

Cited by 30 publications

References 33 publications

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Strategies for safe management of hospital wastewater during the COVID-19 pandemic

30^th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances

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Detection and removal of biologically active organic micropollutants from hospital wastewater

Cited by 30 publications

References 33 publications

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Strategies for safe management of hospital wastewater during the COVID-19 pandemic

30th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances

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Product

Resources

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30^th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances