Detection and toxicity assessment of nitrosamines migration from latex gloves in the Chinese market

Feng, Dan; Wang, Huiping; Cheng, Xuelian; Wang, Jiedong; Ning, Lifeng; Zhou, Qingfeng; Zhou, Yue; Yang, Qian

doi:10.1016/j.ijheh.2009.03.001

Cited by 17 publications

(10 citation statements)

References 14 publications

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“…In general, these results suggested that disinfection by chlorine or chloramine and pre-oxidation during drinking water treatment could produce nitrosamines due to the presence of precursors, which is consistent with previous reports (Chen and Young, 2008;Kemper et al, 2010;W.J. Zhou et al, 2009;Q. Zhou et al, 2009).…”

Section: Occurrence Of Multiple Nitrosamines In Source Water and Finisupporting

confidence: 92%

“…The results in our survey indicated the presence of extensive discharge sources. Previous studies have shown that NDMA may be present in secondary effluents from sewage treatment systems and in effluents from industries including rubber, leather, pesticides, food processing, foundries and dyes (Chen and Young, 2008;Feng et al, 2009). NDEA, NDBA, NMor and NDPhA have been detected in emulsion products, such as condoms, baby bottle nipples, rubber, soothers and gloves, and in tobacco, meat and wines (Thilen and Shishoo, 2000;Verna et al, 1996).…”

Section: Occurrence Of Multiple Nitrosamines In Source Water and Finimentioning

confidence: 99%

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Occurrence and profiling of multiple nitrosamines in source water and drinking water of China

Wang

et al. 2016

Science of The Total Environment

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Section: Occurrence Of Multiple Nitrosamines In Source Water and Finisupporting

confidence: 92%

Section: Occurrence Of Multiple Nitrosamines In Source Water and Finimentioning

confidence: 99%

Occurrence and profiling of multiple nitrosamines in source water and drinking water of China

Wang

et al. 2016

Science of The Total Environment

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“…Sources of contamination can include rubber consumable products such as latex gloves [29] and pipette bulbs, as well as ion exchange resins used to prepare ultrapure water [30]. Blank (un-spiked) matrix samples were run to assess background concentrations of the analytes in ultrapure water and tap water.…”

Section: Analyte Recovery Experimentsmentioning

confidence: 99%

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

McDonald

Harden

Nghiem

et al. 2012

Talanta

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, S. J. (2012). Analysis of N-nitrosamines in water by isotope dilution gas chromatography-electron ionisation tandem mass spectrometry. Talanta, Analysis of N-nitrosamines in water by isotope dilution gas chromatography-electron ionisation tandem mass spectrometry a b s t r a c t A method has been developed for the determination of eight N-nitrosamines in drinking water and treated municipal effluent. The method uses solid phase extraction (SPE), gas chromatography (GC) and analysis by tandem mass spectrometry (MS-MS) with electron ionization (EI). The target compounds are N-nitrosodimethylamine (NDMA), N-nitrosomethyethylamine (NMEA), N-nitrosodiethylamineThe use of direct isotope analogues for isotope dilution analysis of all analytes ensures accurate quantification, accounting for analytical variabilities that may occur during sample processing, extraction and instrumental analysis. Method detection levels (MDLs) were determined to describe analyte concentrations sufficient to provide a signal with 99% certainty of detection. The established MDLs for all analytes were 0.4-4 ng L À 1 in a variety of aqueous matrices. Sample matrices were observed to have only a minor impact on MDLs and the method validation confirmed satisfactory method stability over intra-day and inter-day analyses of tap water and tertiary treated effluent samples.

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“…For all nitrosamines, the method showed satisfactory MDL (0.11-0.50 lg kg -1 ) which were much lower than the limit of Directive 93/11/EEC established by European Union, which the migration of nitrosamines from teats and soothers should not exceed 10 lg kg -1 [29]. Thus, the MDL and linear range of this method were satisfactory for detecting most of the nitrosamines at the levels in common reports [7,8]. The average recoveries of six nitrosamines were satisfactory in the range from 103.42 to 119.64% with the RSD between 6.16 and 11.67%.…”

Section: Methods Evaluationmentioning

confidence: 85%

“…Nitrosamines have been detected in various rubber products, such as baby teats and soothers, condoms, gloves, balloons and rubber nettings, which are widely used in our daily life and work [2][3][4][5][6][7][8]. Nitrosamines in rubber products are formed during vulcanization steps as a consequent of the nitrosation of secondary aminated vulcanization accelerators using nitrogen oxides present in the industrial atmosphere and/or nitrites of uncertain origin [9].…”

Section: Introductionmentioning

confidence: 99%

Determination of Volatile Nitrosamines in Latex Products by HS-SPME–GC–MS

et al. 2011

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Nitrosamines which have been detected in various latex products are carcinogens. The method for determination of volatile nitrosamines in latex products was developed using a combination of headspace solid phase micro-extraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS). A carboxen/polydimethylsiloxane (CAR/PDMS) fiber was used for HS-SPME involving the following variables: (1) agitation conditions, (2) extraction temperature (3) extraction time, and (4) salt concentration. The instrument performances of three detection systems including GC combined thermal energy analyzer, nitrogen chemiluminescence detector and MS were evaluated. The agitation conditions including magnetic stirring and ultrasonication were investigated by the comparison of extraction efficiency of HS-SPME for nitrosamines. Obtained optimal detection conditions of nitrosamines were HS-SPME at 45°C for 60 min assisted with magnetic stirring and saturated NaCl followed by GC-MS. To evaluate this method performance, the commercial products including eleven latex products (gloves, balloons and condoms) and four liquid silicone nipples were analyzed with the method. The results revealed that the method is suitable for simple and effective determination of nitrosamines in latex products. The advantage of this HS-SPME-GC-MS method is simple treatment, fast analysis, adequate sensitivity and without organic solvent.

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Detection and toxicity assessment of nitrosamines migration from latex gloves in the Chinese market

Cited by 17 publications

References 14 publications

Occurrence and profiling of multiple nitrosamines in source water and drinking water of China

Occurrence and profiling of multiple nitrosamines in source water and drinking water of China

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

Determination of Volatile Nitrosamines in Latex Products by HS-SPME–GC–MS

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