Detection Levels of Cytokines (IL-6 and IL-18) and Microbial Parameters in Patients with Renal Failure in Diyala Province

Abstract

Current study was conducted in Diyala province for kidney failure patients ( Ibn Sina Center ) for dialysis in Baqubah teaching hospital and started from beginning August 2016 to end April 2017. A total 100 blood sample had from kidney failure patients, has been the number males 61 and females 39 with age range (10 -88) years and collected 50 of blood sample from oculary healthy individuals act as a control group , has been the number males 25 and females 25 with age range 10 -88 years . By (ELISA) technique detection immunological parameters (IL-6 , IL-18) , and (SRID) for detection microbial parameters (HBV, CMV , T. gondii, HCV) . Result of study expressed that the incidence of disease rate among males 61% more than females 39% with no significant different (P>0.05), also highest rate disease in both age groups (31-50, 51-70) years , while lowest rate disease the age range (10-30 , >70) years recorded with significance different) P <0.05(. So, high levels of ( IL-18) for patients than to control with significance different between study groups (P <0.05), while (IL-6) was raised in patients compared to control. Also, result showed positivity of ( HBV, CMV , T. gondii, HCV ) in patients was (8% , 13%, 10%, 25% ) respectively with high significant different (P<0.05). Conclusions of current study showed male more than female, age period >70 and 51-17 year recorded highest percentage infection ,high levels of immunological (IL-6 and IL-18) in renal dialysis patients, as well as to some microbial infected patients with kidney failure. The aim of study is detection levels of cytokines (IL-6 and IL-18) and some microbial infection in patients with renal failure.