BackgroundNormal coronary flow velocity reserve (CFVR) (≥ 2) obtained in the
left anterior descending coronary artery (LAD) from transthoracic
echocardiography is associated with a good prognosis, but there is no study
correlating CFVR with submaximal target heart rate (HR).ObjectiveTo evaluate the prognostic value of CFVR obtained in the LAD of patients with
preserved (>50%) left ventricular ejection fraction (LVEF) who completed
a dobutamine stress echocardiography (DSE), considering target HR.MethodsProspective study of patients with preserved LVEF and CFVR obtained in the
LAD who completed DSE. In Group I (GI = 31), normal CFVR was obtained before
achieving target HR, and, in Group II (GII = 28), after that. Group III (G
III=24) reached target HR, but CFVR was abnormal. Death, acute coronary
insufficiency, coronary intervention, coronary angiography without further
intervention, and hospitalization were considered events.ResultsIn 28 ± 4 months, there were 18 (21.6%) events: 6% (2/31) in GI, 18%
(5/28) in GII, and 46% (11/24) in GIII. There were 4 (4.8%) deaths, 6 (7.2%)
coronary interventions and 8 (9.6%) coronary angiographies without further
intervention. In event-free survival by regression analysis, GIII had more
events than GI (p < 0.001) and GII (p < 0.045), with no difference
between GI and GII (p = 0.160). After adjustment, the only difference was
between GIII and GI (p = 0.012).ConclusionIn patients with preserved LVEF and who completed their DSE, normal CFVR
obtained before achieving target HR was associated with better
prognosis.