A wide variety of astrophysical and cosmological sources are expected to contribute to a stochastic gravitational-wave background. Following the observations of GW150914 and GW151226, the rate and mass of coalescing binary black holes appear to be greater than many previous expectations. As a result, the stochastic background from unresolved compact binary coalescences is expected to be particularly loud. We perform a search for the isotropic stochastic gravitational-wave background using data from Advanced LIGO's first observing run. The data display no evidence of a stochastic gravitational-wave signal. We constrain the dimensionless energy density of gravitational waves to be Ω0 < 1.7 × 10 −7 with 95% confidence, assuming a flat energy density spectrum in the most sensitive part of the LIGO band (20 − 86 Hz). This is a factor of ∼33 times more sensitive than previous measurements. We also constrain arbitrary power-law spectra. Finally, we investigate the implications of this search for the background of binary black holes using an astrophysical model for the background. The recent detections of binary black hole (BBH) coalescences by Advanced LIGO [32,33] suggest that the Universe may be rich with coalescing BBHs. While events like GW150914 and GW151226 are loud enough to be clearly detected, we expect there to be many more events that are too far away to be individually resolved and that contribute to the background. Since this BBH population originates from sources that are too distant to be individually detected, the stochastic search probes a distinct population of binaries compared to nearby sources [34]. The background from these binaries provides complementary information to individually resolved binary coalescences [35].In this Letter, we report on the search for an isotropic background using data from Advanced LIGO's first observing run O1. We search for the background by crosscorrelating data streams from the two separate LIGO detectors and looking for a coherent signal. We find no evidence for the background and place the best upper limits to date on the energy density of the background in the LIGO frequency band. We also update the impli-