Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow, Daniel D.; Cassada, David A.; –Hunt, Shannon L. Bartelt; Li, Xu; D’Alessio, Matteo; Zhang, Yun; Zhang, Yuping; Sallach, J. Brett

doi:10.2175/106143016x14696400494335

Cited by 18 publications

(9 citation statements)

References 49 publications

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“…The presence of pharmaceuticals (e.g., estrogen and estrogendisrupting compounds, anticonvulsant, psychiatric, and antibiotic drugs) in surface waters and effluent from sewage treatment plants has been a concern for at least 2 decades (Daughton and Ternes 1999). More recently, concerns have emerged about antimicrobials used in animal feedlot operations (Snow et al 2015) and aquaculture (Justino et al 2016). These compounds are frequently detected in municipal wastewater effluent as well as in agricultural runoff in rural areas (Tillitt and Buxton 2012;Liu et al 2015) and have potential adverse consequences for fish populations and humans that consume them.…”

Section: Box 1 Pharmaceuticalsmentioning

confidence: 99%

A Call for Collaboration among Water Quality and Fisheries Professionals

Kusnierz¹,

Jager

Todd³

2020

Fisheries

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Section: Box 1 Pharmaceuticalsmentioning

confidence: 99%

A Call for Collaboration among Water Quality and Fisheries Professionals

Kusnierz¹,

Jager

Todd³

2020

Fisheries

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“…The principal route of 17b-trenbolone entering the environment is through runoff of wastes (urine and feces) from livestock dosed with trenbolone acetate (Lange et al 2002;Kolok and Sellin 2008;Snow et al 2013;Jones et al 2014bJones et al , 2014c. Hence, aquatic species would be most prone to unintended exposures.…”

Section: Environmental Fate and Exposurementioning

confidence: 99%

A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β‐trenbolone

Ankley

Coady

Gross³

et al. 2018

Enviro Toxic and Chemistry

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Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17b-trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlots. The 17b-trenbolone isomer can affect androgen receptor signaling pathways in various vertebrate species at comparatively low concentrations/doses. The present article provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of 17b-trenbolone, with an emphasis on potential risks to aquatic animals. In vitro studies indicate that, although 17b-trenbolone can activate several nuclear hormone receptors, its highest affinity is for the androgen receptor in all vertebrate taxa examined, including fish. Exposure of fish to nanograms per liter water concentrations of 17b-trenbolone can cause changes in endocrine function in the short term, and adverse apical effects in longer exposures during development and reproduction. Impacts on endocrine function typically are indicative of inappropriate androgen receptor signaling, such as changes in sex steroid metabolism, impacts on gonadal stage, and masculinization of females. Exposure of fish to 17b-trenbolone during sexual differentiation in early development can greatly skew sex ratios, whereas adult exposures can adversely impact fertility and fecundity. To fully assess ecosystem-level risks, additional research is warranted to address uncertainties as to the degree/breadth of environmental exposures and potential population-level effects of 17b-trenbolone in sensitive species.

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“…The first model analyte that was considered in this study was the anti-epileptic drug carbamazepine. This compound has been of interest as an emerging contaminant because of its widespread occurrence and relatively high concentrations in water samples, along with its resistance to natural degradation and to common methods for wastewater treatment [2,4,[28][29][30]. These features have led to the use of carbamazepine in a number of studies as a general indicator for emerging contaminants in wastewater [22,23,28].…”

Section: Initial Column Developmentmentioning

confidence: 99%

“…Over the last two decades there has been increasing interest in biologically-active contaminants in environmental samples such as water [1][2][3][4][5][6][7][8][9][10][11][12][13]. These contaminants can arise from municipal, industrial, and agricultural sources and include many substances whose potential effects on the environment and human health are not fully understood and for which regulations are not yet in place [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…This report describes the development and testing of affinity sorbents containing BSA for use in the on-line extraction and analysis of biologically-active environmental contaminants in water, as carried out by LC-MS/MS or LC. Several model compounds of interest as emerging contaminants are used in the evaluation of these BSA sorbents; these compounds include carbamazepine, which is often used as a general marker for such contaminants in water [2][3][4]22,23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

Papastavros

Remmers

Snow

et al. 2018

J of Separation Science

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Affinity sorbents using bovine serum albumin as a binding agent were developed and tested for the extraction of environmental contaminants from water. Computer simulations based on a countercurrent distribution model were also used to study the behavior of these sorbents. Several model drugs, pesticides, and hormones of interest as emerging contaminants were considered in this work, with carbamazepine being used as a representative analyte when coupling the albumin column on-line with liquid chromatography and tandem mass spectrometry. The albumin column was found to be capable of extracting carbamazepine from aqueous solutions that contained trace levels of this analyte. Further studies of the bovine serum albumin sorbent indicated that it had higher retention under aqueous conditions than a traditional C support for most of the tested emerging contaminants. Potential advantages of using these protein-based sorbents included the low cost of bovine serum albumin and its ability to bind to a relatively wide range of drugs and related compounds. It was also shown how simulations could be used to describe the elution behavior of the model compounds on the bovine serum albumin sorbents as an aid in optimizing the retention and selectivity of these supports for use with liquid chromatography or methods such as liquid chromatography with tandem mass spectrometry.

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Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Cited by 18 publications

References 49 publications

A Call for Collaboration among Water Quality and Fisheries Professionals

A Call for Collaboration among Water Quality and Fisheries Professionals

A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β‐trenbolone

Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

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