Detection of a miRNA biomarker for cancer diagnosis using SERS tags and magnetic separation

Treerattrakoon, Kiatnida; Roeksrungruang, Pimporn; Dharakul, Tararaj; Japrung, Deanpen; Faulds, Karen; Graham, Duncan

doi:10.1039/d2ay00210h

Cited by 12 publications

(2 citation statements)

References 49 publications

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“…The regulation of miRNAs is influenced by oncogenic viruses in a variety of ways [103], including upregulating the host miRNA to stimulate the division of virally infected cells, encoding viral miRNAs that target the mRNA of the host cell, and reducing the miRNA of the host that restricts tumor growth. Electrodes for measuring miRNA-21 concentrations in the serum of breast cancer patients are modified using AuNPs@NIPAm-co-AAc microgel nanocomposites [104]. The SERS platform, which is based on nanotechnology, offers a precise and focused investigation of the miR-29a biomarker for cancer diagnosis [104].…”

Section: Microrna (Mirna) Biomarkersmentioning

confidence: 99%

“…Electrodes for measuring miRNA-21 concentrations in the serum of breast cancer patients are modified using AuNPs@NIPAm-co-AAc microgel nanocomposites [104]. The SERS platform, which is based on nanotechnology, offers a precise and focused investigation of the miR-29a biomarker for cancer diagnosis [104]. A simple blood sample is adequate to detect the presence of miRNAs because miRNAs are not affected by the RNase enzyme and, hence, circulating miRNAs are more stable.…”

Section: Microrna (Mirna) Biomarkersmentioning

confidence: 99%

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Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

et al. 2023

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Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis and treatment. Nanomaterials are extensively employed in the field of oncology because of their minute size and ultra-specificity. A wide range of nanocarriers, such as dendrimers, micelles, PEGylated liposomes, and polymeric nanoparticles are used to facilitate the efficient transport of anti-cancer drugs at the target tumor site. Real-time labeling and monitoring of cancer cells using quantum dots is essential for determining the level of therapy needed for treatment. The drug is targeted to the tumor site either by passive or active means. Passive targeting makes use of the tumor microenvironment and enhanced permeability and retention effect, while active targeting involves the use of ligand-coated nanoparticles. Nanotechnology is being used to diagnose the early stage of cancer by detecting cancer-specific biomarkers using tumor imaging. The implication of nanotechnology in cancer therapy employs photoinduced nanosensitizers, reverse multidrug resistance, and enabling efficient delivery of CRISPR/Cas9 and RNA molecules for therapeutic applications. However, despite recent advancements in nano-oncology, there is a need to delve deeper into the domain of designing and applying nanoparticles for improved cancer diagnostics.

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Section: Microrna (Mirna) Biomarkersmentioning

confidence: 99%

Section: Microrna (Mirna) Biomarkersmentioning

confidence: 99%

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

et al. 2023

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miRNA interplay: Mechanisms and therapeutic interventions in cancer

Wang,

Zhou

et al. 2024

MedComm – Oncology

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MicroRNAs (miRNAs) are key molecules that regulate gene expression. miRNAs regulate protein synthesis by binding to mRNA, influencing processes such as cell proliferation, metastasis, and apoptosis. They play a pivotal role in cancer development. Current research mainly explores miRNA mechanisms and applications, and the techniques underpinning this research are foundational to both basic science and clinical translation. However, no review has comprehensively examined miRNA mechanisms and applications from a technical perspective, creating a need for this work. Advances in RNA sequencing technology, CRISPR/Cas9 technology, and bioinformatics tools have deepened our understanding of miRNA interactions. miRNA can serve as a biomarker for cancer diagnosis and prognosis, with significant clinical potential. The development of miRNA mimics and inhibitors has brought new hope for cancer treatment, especially in reversing cancer drug resistance. This article reviews the vital role of miRNA interactions in cancer occurrence, development, diagnosis, and treatment, providing new perspectives and strategies for personalized medicine and cancer therapy.

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Surface-Enhanced Raman Scattering (SERS)-based biosensors for advanced extracellular vesicle detection: A review

Fan,

Chen,

Lan

et al. 2024

Analytica Chimica Acta

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Detection of a miRNA biomarker for cancer diagnosis using SERS tags and magnetic separation

Abstract: Detection of miR-29a, a biomarker of cancers, using SERS tags and magnetic separation is described. The assay was designed to detect the miR-29a sequence by taking the complementary sequence and...

Cited by 12 publications

References 49 publications

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

miRNA interplay: Mechanisms and therapeutic interventions in cancer

Surface-Enhanced Raman Scattering (SERS)-based biosensors for advanced extracellular vesicle detection: A review

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