Detection of a multi‐disease biomarker in saliva with graphene field effect transistors

Kumar, Narendra; Gray, Mason; Ortiz‐Marquez, Juan C.; Weber, Andrew M.; Desmond, Cameron R.; Argun, Avni A.; Opijnen, Tim van; Burch, Kenneth S.

doi:10.1002/mds3.10121

Cited by 13 publications

(16 citation statements)

References 60 publications

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“…PBASE was the linking molecule for aptamer immobilization which bonded with graphene through π-π interactions. This methodology was capable of detecting low concentrations (70 pM) of the target oncobiomarker which in could act as an alternative technique in the early detection of diseases related to variations in CA1 level [117]. A similar strategy was used to functionalize the surface of a GFET with anti-CD63 antibodies for detecting exosomes.…”

Section: Cancer Biomarkermentioning

confidence: 99%

Laser-Induced Graphene-Functionalized Field-Effect Transistor-Based Biosensing: A Potent Candidate for COVID-19 Detection

Sadighbayan

Minhas-Khan

Ghafar-Zadeh

2022

IEEE Trans.on Nanobioscience

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Speedy and on-time detection of coronavirus disease 2019 (COVID-19) is of high importance to control the pandemic effectively and stop its disastrous consequences. A widely available, reliable, label-free, and rapid test that can recognize tiny amounts of specific biomarkers might be the solution. Nanobiosensors are one of the most attractive candidates for this purpose. Integration of graphene with biosensing devices shifts the performance of these systems to an incomparable level. Between the various arrangements using this wonder material, field-effect transistors (FETs) display a precise detection even in complex samples. The emergence of pioneering biosensors for detecting a wide range of diseases especially COVID-19 created the incentive to prepare a review of the recent graphene-FET biosensing platforms. However, the graphene fabrication and transfer to the surface of the device is an imperative factor for researchers to take into account. Therefore, we also reviewed the common methods of manufacturing graphene for biosensing applications and discuss their advantages and disadvantages. One of the most recent synthesizing techniques -laser-induced graphene (LIG)is attracting attention owing to its extraordinary benefits which are thoroughly explained in this article. Finally, a conclusion highlighting the current challenges is presented.

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Section: Cancer Biomarkermentioning

confidence: 99%

Laser-Induced Graphene-Functionalized Field-Effect Transistor-Based Biosensing: A Potent Candidate for COVID-19 Detection

Sadighbayan

Minhas-Khan

Ghafar-Zadeh

2022

IEEE Trans.on Nanobioscience

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“…Small islands of ≈7 nm height seen in Figure 5c are consistent with previously reported findings where aptamers were immobilization on a substrate. [34][35][36]…”

Section: Fabrication Of Aptamer-functionalized Idmementioning

confidence: 99%

Engineered Nucleotide Chemicapacitive Microsensor Array Augmented with Physics‐Guided Machine Learning for High‐Throughput Screening of Cannabidiol

Yap

Pan

Linh

et al. 2022

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The recent legalization of cannabidiol (CBD) to treat neurological conditions such as epilepsy has sparked rising interest across global pharmaceuticals and synthetic biology industries to engineer microbes for sustainable synthetic production of medicinal CBD. Since the process involves screening large amounts of samples, the main challenge is often associated with the conventional screening platform that is time consuming, and laborious with high operating costs. Here, a portable, high‐throughput Aptamer‐based BioSenSing System (ABS3) is introduced for label‐free, low‐cost, fully automated, and highly accurate CBD concentrations’ classification in a complex biological environment. The ABS3 comprises an array of interdigitated microelectrode sensors, each functionalized with different engineered aptamers. To further empower the functionality of the ABS3, unique electrochemical features from each sensor are synergized using physics‐guided multidimensional analysis. The capabilities of this ABS3 are demonstrated by achieving excellent CBD concentrations’ classification with a high prediction accuracy of 99.98% and a fast testing time of 22 µs per testing sample using the optimized random forest (RF) model. It is foreseen that this approach will be the key to the realistic transformation from fundamental research to system miniaturization for diagnostics of disease biomarkers and drug development in the field of chemical/bioanalytics.

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“…Although diluted buffer solutions, desalting, or purification can increase the Debye screening length, post-processing compromises the real time sensing capabilities of bioelectronics. 65 Shorter bioreceptors such as truncated antibodies 66 and aptamers 67,68 have also been exploited to overcome the charge screening effect, but their application is typically limited by their complex design/synthesis.…”

Section: Biochemical Signalingmentioning

confidence: 99%

Hydrogel facilitated bioelectronic integration

Hsu

Jiang

2021

Biomater. Sci.

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Detection of a multi‐disease biomarker in saliva with graphene field effect transistors

Cited by 13 publications

References 60 publications

Laser-Induced Graphene-Functionalized Field-Effect Transistor-Based Biosensing: A Potent Candidate for COVID-19 Detection

Laser-Induced Graphene-Functionalized Field-Effect Transistor-Based Biosensing: A Potent Candidate for COVID-19 Detection

Engineered Nucleotide Chemicapacitive Microsensor Array Augmented with Physics‐Guided Machine Learning for High‐Throughput Screening of Cannabidiol

Hydrogel facilitated bioelectronic integration

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