Detection of Actinomyces spp. in cervical exudates from women with cervical intraepithelial neoplasia or cervical cancer

Abstract

Patients with cervical cancer had a higher prevalence of the presence of Actinomyces compared to the CIN and control groups. This is the first study in which a deliberate search of this genus has been performed in women with cervical pathologies. The use of specific primers for each species facilitated their detection in comparison with traditional isolation methods. More information is necessary to understand the molecular mechanisms involved in the complex role that bacterial communities may play in the development of cancer (and vice versa).

Infection versus cancer: management of actinomyces mimicking cervical cancer or ovarian cancer

“…As the bacterial density is high in mucous membranes, microbiota may also play a role in the development of pre-cancerous or cancerous lesions of the uterine cervix. 8 Although García et al 7 demonstrated a higher prevalence of actinomyces in patients with cervical pathology when compared with healthy women, the role of this pathogen in pre-invasive and invasive cervical lesions has not been yet confirmed.…”

Oropharynx microbiota transitions in hypopharyngeal carcinoma treatment of induced chemotherapy followed by surgery

“…The genera Fusobacterium , Actinomyces , and Parvinmonas were found to increase in advanced stage HPSCC. Genus Actinomyces is a dangerous bacterium that correlates with cervical carcinoma [ 32 ]. Genus Parvimonas ( Parvimonas micra) is connected with infection and gastric carcinoma [ 33 ].…”

The salivary microbiota is altered in cervical dysplasia patients and influenced by conization

“…Other studies imply that these four genera are all oral opportunistic pathogens and can be linked to inflammatory reactions and cancer development [ 16 , 39 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. Notably, a significant increase of Prevotella and Actinomyces has been previously reported in vaginal or cervical exudates from women with cervical dysplasia or cervical cancer [ 10 , 58 , 59 ]. This finding suggests the potential for the transfer of these opportunistic pathogens between the oral and vaginal tracts.…”

“…Actinomyces , which is significantly increased among smokers in our study, had been linked to higher gingivitis risk among cigarette smokers in other studies [ 67 , 68 , 69 , 70 , 71 ]. Cigarette smoking is an independent risk factor for cervical dysplasia occurrence and development [ 21 , 59 , 72 , 73 ]. We identified a significant positive relationship between the RLR pathway and Actinomyces among patients with dysplasia than the ones without, and among smokers than nonsmokers.…”