Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA

Walkowiak, Agata; Ledziński, Łukasz; Zapadka, Mariusz; Kupcewicz, Bogumiła

doi:10.1016/j.saa.2018.10.008

Cited by 58 publications

(20 citation statements)

References 27 publications

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“…DNJ (1,5 dideoxy-1,5-imino-d-sorbitol), an alkaloid present in leaves, inhibits the activity of α-glycosidases [114][115][116]. Another dietary supplement component which is widely recognized as rich source of bioactive compounds, are Ginkgo biloba leaves [117,118]. Ginkgo leaves contain substances belonging to flavonoid, terpene and proanthocyanidin groups which thanks to their proportions in the leaves provides beneficial health effects [118].…”

Section: Functional Food Products With Cornelian Cherrymentioning

confidence: 99%

“…Another dietary supplement component which is widely recognized as rich source of bioactive compounds, are Ginkgo biloba leaves [117,118]. Ginkgo leaves contain substances belonging to flavonoid, terpene and proanthocyanidin groups which thanks to their proportions in the leaves provides beneficial health effects [118]. These ingredients help to improve the blood flow in the brain, due to their protective effect against the peroxidation of cerebral lipids.…”

Section: Functional Food Products With Cornelian Cherrymentioning

confidence: 99%

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Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Szczepaniak

Kobus‐Cisowska

Kusek

et al. 2019

Eur Food Res Technol

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Cornus mas, also known as the Cornelian cherry, is a plant that grows in Eastern Europe and the Middle East. Its green leaves and reddish oval fruits are associated with many beneficial properties such as antioxidative and anti-inflammatory effects. These features are driven by the rich polyphenolic composition, with anthocyanins and iridoids in Cornelian cherry fruits as well as flavonoids and phenolic acids in leaves. The antioxidant behavior as well as the composition significantly depends on the cultivar of the plant and its genotype. The functional properties of Cornelian cherry have been recognized in many in vitro and toxicological studies. Cornus mas fruits and their extracts have been found to have significant antiatherogenic, anti-inflammatory, and neuroprotective effects. The beneficial effect of C. mas fruits as a food component has been determined in numerous papers focused on functional food. However, there is no information in existing literature about C. mas leaves in functional food applications. This paper presents the results of current studies including their synthesis to answer the question whether the Cornelian cherry exhibits positive properties due to its bioactive compound content.

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Section: Functional Food Products With Cornelian Cherrymentioning

confidence: 99%

Section: Functional Food Products With Cornelian Cherrymentioning

confidence: 99%

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Szczepaniak

Kobus‐Cisowska

Kusek

et al. 2019

Eur Food Res Technol

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“…Several analytical methodologies have been proposed for authenticity assessment of ginkgo-containing herbal products based on liquid chromatography coupled to mass spectrometry (LC-MS), high performance thin layer chromatography (HPTLC), HPTLC coupled with nuclear magnetic resonance and spectroscopy [1,3,[11][12][13][14]. Those methodologies rely on the identification of bioactive compounds and/or chemical profile, which can be affected by several external factors, such as the plant part/tissue, plant age, environmental conditions, geographical location, and storage conditions, among others.…”

Section: Introductionmentioning

confidence: 99%

Authentication of Ginkgo biloba Herbal Products by a Novel Quantitative Real-Time PCR Approach

Grazina

Amaral

Costa

2020

Foods

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Ginkgo biloba is a widely used medicinal plant. Due to its potential therapeutic effects, it is an ingredient in several herbal products, such as plant infusions and plant food supplements (PFS). Currently, ginkgo is one of the most popular botanicals used in PFS. Due to their popularity and high cost, ginkgo-containing products are prone to be fraudulently substituted by other plant species. Therefore, this work aimed at developing a method for G. biloba detection and quantification. A new internal transcribe spacer (ITS) marker was identified, allowing the development of a ginkgo-specific real-time polymerase chain reaction (PCR) assay targeting the ITS region, with high specificity and sensitivity, down to 0.02 pg of DNA. Additionally, a normalized real-time PCR approach using the delta cycle quantification (ΔCq) method was proposed for the effective quantification of ginkgo in plant mixtures. The method exhibited high performance parameters, namely PCR efficiency, coefficient of correlation and covered dynamic range (50–0.01%), achieving limits of detection and quantification of 0.01% (w/w) of ginkgo in tea plant (Camellia sinensis). The quantitative approach was successfully validated with blind mixtures and further applied to commercial ginkgo-containing herbal infusions. The estimated ginkgo contents of plant mixture samples suggest adulterations due to reduction or almost elimination of ginkgo. In this work, useful and robust tools were proposed to detect/quantify ginkgo in herbal products, which suggests the need for a more effective and stricter control of such products.

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“…The main groups of active components in ginkgo are terpenoids (ginkgolides and bilobalide and flavonoids (e.g., glycosides of kaempferol, quercetin, isorhamnetin) (J. Kobus-Cisowska, Szymanowska-Powałowska et al, 2019;Stark & Behl, 2012;Walkowiak et al, 2019). Flavonoids constitute a significant group of active substances in G. biloba.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, numerous studies are being conducted on specific natural compounds which may be reversible inhibitors of acetylcholine esterase which is crucial for the improvement of transmission in the cholinergic system of the central nervous system (Bilska et al, 2019;Q. Li et al, 2018;Walkowiak et al, 2019). Green leaves of Ginkgo biloba have been identified as a dietary source of compounds which may contribute to the improvement of the brain function and nerve transmission.…”

Section: Introductionmentioning

confidence: 99%

Phytocomponents and evaluation of acetylcholinesterase inhibition by Ginkgo biloba L. leaves extract depending on vegetation period

Kobus‐Cisowska

Dziedziński

Szczepaniak

et al. 2020

CyTA - Journal of Food

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Leaves of the Ginkgo biloba L. have been identified as a source of bioactive compounds and their consumption may lead to the improvement of the brain function. During two vegetation periods, extracts of green and yellow leaves of Ginkgo biloba were analyzed for their chemical constituents and health properties. Samples were analyzed via HPLC and GC methods for the presence and content of phytochemicals. The antioxidant effect towards DPPH and ABTS radicals was studied. The antioxidant activity of samples was measured in Rancimat and Oxidograph tests along with the effectiveness of samples as inhibitors against cholinesterase. The content of individual phytochemicals was found to depend on the harvesting period and type of solvent used in the extraction process. Gingko yellow leaf extracts showed highest radical-scavenging activity as well as cholinesterase inhibition activity, and can be a valuable raw material to produce extracts possessing high cholinesterase inhibition activity.

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Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA

Cited by 58 publications

References 27 publications

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Authentication of Ginkgo biloba Herbal Products by a Novel Quantitative Real-Time PCR Approach

Phytocomponents and evaluation of acetylcholinesterase inhibition by Ginkgo biloba L. leaves extract depending on vegetation period

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