Computational intelligence techniques have emerged as a promising approach to the diagnosis of various medical conditions, including memory impairment. The increasing abuse of psychoactive drugs presents a global public health burden, as repeated exposure to these substances can cause neurodegeneration, premature aging, and negatively affect memory impairment. Although the basis for these neurotoxic effects has not been fully elucidated, compelling evidence has shown that dysregulation of neurotransmission, disruption of mitochondrial function and dynamics, impairment of neuroimmunomodulation, and epigenetic changes result from many psychoactive substances. (eg, alcohol, cannabis, opiates, amphetamines and cocaine). Computational intelligence used in this study to classify the brain image from MRI or CT scan and show the effective of dose ratio on the health with time of treatment, diagnosis of memory impairment in psychoactive substance users. Understanding the neurotoxic profiles of psychoactive substances and the underlying pathways is assumed to be of great importance towards improved risk assessment and treatment of substance use disorders. As such, we found the brain diagram and its effect on drug-induced cellular and molecular mechanisms. thus we conclude that good classification in such field may save human life or early detection of memory impairment via classification of brain cells and tissues.