Detection of an NDM-1-producing Acinetobacter bereziniae strain in Brazil

Chagas, Thiago Pavoni Gomes; Carvalho-Assef, Ana Paula D’Alincourt; Aires, Caio Augusto Martins; Bertocini, Rita; Asensi, Marise Dutra

doi:10.1016/j.jgar.2015.03.005

Cited by 16 publications

(6 citation statements)

References 7 publications

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“…To this date, detection of bla NDM-1 has been occasionally reported in some Acinetobacter species, especially A. baumannii , worldwide [ 15 ]. However, only four similar cases were reported for A. bereziniae : from India (2005) [ 16 ], Argentina (2014) [ 17 ], Brazil (2014) [ 18 ] and Burkina Faso [ 19 ]. Ours is the first to report bla NDM-1 carriage in three distinct carbapenem-resistant clinical A. bereziniae isolates in China and the East Asian region.…”

Section: Discussionmentioning

confidence: 99%

“…Ours is the first to report bla NDM-1 carriage in three distinct carbapenem-resistant clinical A. bereziniae isolates in China and the East Asian region. In previous studies from South Asia and South America, bla NDM-1 in A. bereziniae was reportedly located in Tn 125 , downstream of IS Aba125 within a plasmid, which is presumably acquired via conjugation [ 16 , 17 , 18 ]. Our preliminary study also supported that bla NDM-1 might be on Tn 125 , but whether it is embedded in a plasmid remained uncertain, since several of our assays on plasmid(s) curing proved unsuccessful among the R-type strains (data not shown).…”

Section: Discussionmentioning

confidence: 99%

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First identification of multidrug-resistant Acinetobacter bereziniae isolates harboring blaNDM-1 from hospitals in South China

Pan

Seifert

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

First identification of multidrug-resistant Acinetobacter bereziniae isolates harboring blaNDM-1 from hospitals in South China

Pan

Seifert

et al. 2023

Heliyon

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“…5 Infections caused by A. bereziniae are rarely reported and this species is not frequently isolated. Nevertheless, it has already been identified in the nosocomial environment worldwide, including in Brazil, where studies had shown that this species may be the reservoir of bla IMP-1 and bla NDM-1 genes 6,36 or even carry more than one MBL gene. 23 Our results correlate to this occurrence, since both strains carried bla IMP-1 , which was inserted into In86, as first described in Acinetobacter species and Pseudomonas putida from the 2000s.…”

Section: Discussionmentioning

confidence: 99%

Genomic and Clinical Characterization of IMP-1-Producing Multidrug-Resistant Acinetobacter bereziniae Isolates from Bloodstream Infections in a Brazilian Tertiary Hospital

Tavares

Cunha

Vasconcellos

et al. 2020

Microbial Drug Resistance

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Acinetobacter baumannii is the main species of the Acinetobacter genus; however, non-baumannii Acinetobacter (NBA) species causing infections have been described for the past years, as well as antimicrobial resistance. In this study, we describe the occurrence of two multidrug-resistant (MDR) IMP-1-producing Acinetobacter bereziniae isolates recovered from bloodstream infections in different patients but in the same intensive care unit among 134 carbapenem-resistant Acinetobacter screened. Antimicrobial susceptibility testing revealed resistance to carbapenems, extended spectrum, and antipseudomonad cephalosporins, amikacin, and trimethoprim-sulfamethoxazole. Both A. bereziniae isolates shared the same ApaI-pulsed-field gel electrophoresis (PFGE) pattern. Whole-genome sequencing of both isolates revealed that bla IMP-1 was embedded into an In86 Class I integron carrying also sul1, aac(6¢)-31, and aadA genes. A new sequence type (ST1309 Pasteur) was deposited. The virulence genes lpxC and ompA, seen in A. baumannii, were detected in the A. bereziniae strains. Recognition of A. bereziniae causing invasive MDR infection underscores the role of NBA species as human pathogens especially in at-risk patients.

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“…Although several other carbapenemase-producing bacteria (KPC, GES, SPM, VIM) are reported to cause outbreaks or have endemic behavior in some Latin American institutions, the NDM enzyme has only been described in a few locations 2 . In Brazil, the enzyme has already been described in some states, such as Rio Grande do Sul, São Paulo, Paraná, Rio de Janeiro, Santa Catarina, Bahia, and Pernambuco [3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 98%

Challenges of Multidrug-resistant New Delhi Metallo-beta-Lactamase (NDM-1)-producing Enterobacteriaceae in Kidney Transplant Patients

Foresto¹,

Menezes²,

Nishimura³

et al. 2021

J. Bras. Nefrol.

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Background: The emergence of multidrug-resistant NDM-1-producing enterobacteriaceae strains has become a threat to inpatients, especially to immunosuppressed ones, such as kidney transplant recipients. NDM-1 is a carbapenemase that makes gram-negative bacteria resistant to many types of antibiotics. The incidence of carbapenemase-producing enterobacteria infection in solid organ transplant recipients is around 3 to 10%, with a mortality rate of up to 30%. Methods: We present a case series of 4 patients with NDM-1-producing enterobacteria isolated in urine cultures or rectal swabs. We also conducted a cross-sectional study 30 days after patient identification, collecting surveillance cultures (rectal swab) from all inpatients to assess the extent of spread of this resistance mechanism; a total of 101 patients were included. Results: Two patients were adequately treated with negative control cultures. The other two patients were not treated because they were asymptomatic and had subsequent negative urine cultures. No new colonization was identified in the cross-sectional screening, and no new cases of urinary NDM-1 infection were recorded after a 4-year follow-up. Conclusion: Surveillance for infections caused by multidrug-resistant strains in hospitals treating immunosuppressed patients should be continued and prompt action should be taken in cases of outbreaks of multidrug-resistant infections.

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Detection of an NDM-1-producing Acinetobacter bereziniae strain in Brazil

Cited by 16 publications

References 7 publications

First identification of multidrug-resistant Acinetobacter bereziniae isolates harboring blaNDM-1 from hospitals in South China

First identification of multidrug-resistant Acinetobacter bereziniae isolates harboring blaNDM-1 from hospitals in South China

Genomic and Clinical Characterization of IMP-1-Producing Multidrug-Resistant Acinetobacter bereziniae Isolates from Bloodstream Infections in a Brazilian Tertiary Hospital

Challenges of Multidrug-resistant New Delhi Metallo-beta-Lactamase (NDM-1)-producing Enterobacteriaceae in Kidney Transplant Patients

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