Detection of anti-Borrelia burgdorferi antibodies in buffaloes (Bubalus bubalis) in the state of Pará, Brazil

Corrêa, Fabíola do Nascimento; Teixeira, Rafaella Câmara; Oliveira, Carlos Magno Chaves; Barbosa, José Diomedes; Fonseca, Adivaldo Henrique da

doi:10.1590/s1984-29612012000300033

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…has been studied in different animal species at Rio de Janeiro (RJ), São Paulo (SP) and Pará (PA) states and these studies have shown prevalences, ranging from 9.7% to 83.91% using different sorological methodologies (ALVES et al, 2004;CORDEIRO et al, 2012;CORREA et al, 2012;JOPPERT et al, 2001;SOARES et al, 1999). It is important to emphasize that among dogs, the frequency of these antibodies has doubled in the last 14 years in the Rio de Janeiro state (SOARES et al, 2000;ALVES et al, 2004;CORDEIRO et al, 2012, SOARES et al, 1999.…”

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confidence: 99%

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First record of Borrelia burgdorferi sensu lato antibodies in stray dogs in the Northwest Region of Parana State, Brazil

et al. 2015

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The aim of this study was to determine the occurrence of B. burgdorferi sensu lato s.l. antibodies in stray dogs of the urban area of Umuarama Town, localized in the northwest region of Parana state, Brazil. Serum samples from 168 dogs were tested using indirect immunofluorescence assay (IFA) and Western Blot (WB) in order to detect anti-Borrelia burgdorferi s.l. antibodies. The IFI analysis was used as screening test and positive results were confirmed employing the WB technique. Sixty-five (38.69%) of 168 serum samples were positive in the IFI; 54 of them (83.07%) were confirmed by the WB. The overall data analysis confirmed the presence of anti-B. burgdorferi s.l. antibodies in 32.14% (54/168) dogs, what suggests that northwest region of Parana State may constitute a risk area for Lyme disease. Further studies are necessary to determine the epidemiological characteristics of this disease in the region studied. Key words: Borreliosis, canids, diagnostic, IFA, western blot ResumoO objetivo deste estudo foi determinar a ocorrência de anticorpos anti-B. burgdorferi sensu lato sl em cães errantes da área urbana da cidade de Umuarama, localizado na região noroeste do estado do Paraná, Brasil. Amostras de soro de 168 cães foram testados utilizando imunofluorescência indireta (IFI) e Western Blot (WB), a fim de detectar anticorpos anti-Borrelia burgdorferi sl. A IFI foi utilizada como teste de triagem e os resultados positivos foram confirmados empregando a técnica de WB. Sessenta e cinco (38,69%) de 168 amostras de soro foram positivas na IFI; 54 deles (83,07%) foram confirmados pela WB. A análise geral dos dados confirmaram a presença de anticorpos anti-B. burgdorferi sl em

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Section: Resultsmentioning

confidence: 99%

“…antibodies in cattle, buffalos, equines, dogs and humans (CORREA et al, 2012;DANTAS-TORRES, 2008;JOPPERT et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

First record of Borrelia burgdorferi sensu lato antibodies in stray dogs in the Northwest Region of Parana State, Brazil

et al. 2015

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The presence of Borrelia theileri in Argentina

Morel

Salvo²,

Cicuttin³

et al. 2019

Veterinary Parasitology: Regional Studies and Reports

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Lyme borreliosis in Brazil: a critical review on the Baggio–Yoshinari syndrome (Brazilian Lyme-like disease)

Labruna,

Faccini-Martínez,

Muñoz-Leal

et al. 2024

Clin Microbiol Rev

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SUMMARY Lyme borreliosis or Lyme disease is the most frequently reported tick-borne disease in the Northern Hemisphere. In countries of the Southern Hemisphere, such as Brazil, since the early 1990s, some researchers have argued for the existence of an autochthonous Lyme-like borreliosis, known locally as the Baggio–Yoshinari syndrome (BYS), an alleged “Brazilian borreliosis” supposedly caused by a different strain of Borrelia burgdorferi and transmitted by hard ticks. Currently, the existence of BYS in Brazil is still accepted by a large part of the human health care workers, scientists, medical societies, and patients. In fact, this alleged “Brazilian borreliosis” has been the tick-borne zoonotic disease with the greatest number of reported cases and published studies in Brazil during this century, second only to Brazilian spotted fever. In this manuscript, we reviewed all manuscripts directly related to BYS that have been published in Brazil during the last 35 years. This analysis included 199 individual human cases that have been reported in Brazil since 1989, plus multiple studies on ticks, domestic, and wild animals. Our revision aimed to provide a critical opinion on whether the current published works allow healthcare workers, public health agencies, and patients to accept the existence of Lyme disease, BYS, or other Lyme borreliosis-related disease in Brazil. For this purpose, we evaluated the strengths and weaknesses of each published study, considering the diagnostic methods used, such as serological, microbiological, and molecular analyses. Based on these evaluations, we conclude that there is not enough evidence to support the occurrence of Lyme borreliosis in Brazil or that BYS (Brazilian Lyme-like disease) is caused by a bacterium of the genus Borrelia . This assumption is based on the inaccuracy, unreliability, and misinterpretation of the different diagnostic methods that have been used in Brazil. Recognizing the lack of technical evidence for the occurrence of Lyme borreliosis in Brazil has highly relevant implications. For example, it becomes imperative to raise awareness among the country’s medical profession, as they have adopted unnecessary and extreme therapies recommended for patients with a supposed borrelial infection, including BYS, in Brazil. Finally, the technical analyses carried out in this study could be applied to other countries in the Southern Hemisphere ( e.g. , Argentina, South Africa, Australia), where cases classified and alleged as Lyme disease have been reported.

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Detection of anti-Borrelia burgdorferi antibodies in buffaloes (Bubalus bubalis) in the state of Pará, Brazil

Cited by 4 publications

References 17 publications

First record of Borrelia burgdorferi sensu lato antibodies in stray dogs in the Northwest Region of Parana State, Brazil

First record of Borrelia burgdorferi sensu lato antibodies in stray dogs in the Northwest Region of Parana State, Brazil

The presence of Borrelia theileri in Argentina

Lyme borreliosis in Brazil: a critical review on the Baggio–Yoshinari syndrome (Brazilian Lyme-like disease)

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