Detection of anti-hsp70 immunoglobulin G antibodies indicates better outcome in coronary artery bypass grafting patients suffering from severe preoperative angina

Vogt, Sebastian; Portig, Irene; Kusch, B.; Pankuweit, Sabine; Sirat, Abdul Sami; Troitzsch, D; Maisch, Bernhard; Moosdorf, Rainer

doi:10.1016/j.athoracsur.2004.03.082

Cited by 12 publications

(11 citation statements)

References 22 publications

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“…Detection of anti-HSP70 antibodies have been shown to correlate with better outcome of patients after CABG surgery, and may play a role in regulation of HSP70 expression known to protect cardiac tissue from ischemic injury. In accordance with this finding, the detection of these antibodies was directly correlated with a low antioxidative capacity of patient's sera [9].…”

Section: Pulmonary Parameterssupporting

confidence: 68%

Different Profile of Antioxidative Capacity Results in Pulmonary Dysfunction and Amplified Inflammatory Response After CABG Surgery

Vogt

Sattler

Sirat

et al. 2007

Journal of Surgical Research

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Section: Pulmonary Parameterssupporting

confidence: 68%

Different Profile of Antioxidative Capacity Results in Pulmonary Dysfunction and Amplified Inflammatory Response After CABG Surgery

Vogt

Sattler

Sirat

et al. 2007

Journal of Surgical Research

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“…However, no association between antibodies to Hsp70 and cardiovascular diseases was observed in investigations from distinct laboratories including our own (Portig et al 1997;Yang et al 2004a), although Hsp70 is known to play a key role in cytoprotection of heart from ischemia and other harmful stimuli. Recently, antibodies to Hsp70 were found in patients with severe angina, but not chronic angina, and interestingly, the former patients had an improved outcome following coronary artery bypass grafting (Vogt et al 2004). Rea et al (2001) observed that Hsp60, Hsp70, antiHsp60, anti-Hsp65, and anti-Hsp70 were detectable in 60 healthy individuals aged from 20 to 96 years.…”

Section: Cardiovascular Diseases and Cerebral Injurymentioning

confidence: 99%

Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?

Tanguay²

2006

Cell Stress Chaper

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Heat shock proteins (Hsps) can be found in two forms, intracellular and extracellular. The intracellular Hsps are induced as a result of stress and have been found to be cytoprotective in many instances due to their chaperone functions in protein folding and in protein degradation. The origin and role of extracellular Hsps is less clear. Although they were suspected originally to be released from damaged cells (necrosis), their presence in most normal individuals rather suggests that they have regulatory functions in circulation. As immunodominant molecules, Hsps can stimulate the immune system, leading to the production of autoantibodies recognizing epitopes shared by microbial and human Hsps. Thus, extracellular Hsps can influence the inflammatory response as evidenced by the production of inflammatory cytokines. Antibodies to Hsps have been found under normal conditions but seem to be increased in certain stresses and diseases. Such antibodies could regulate the inflammatory response positively or negatively. Here, we review the literature on the findings of antibodies to Hsps in situations of environmental or occupational stress and in a number of diseases and discuss their possible significance for the diagnosis, prognosis, or pathogenesis of these diseases.

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“…A small study has documented that patients with stable (n=40) and unstable angina (n=91) exhibit lower serum anti-Hsp70 antibody levels compared to controls (n=18; Herz et al, 2006). In addition, the presence of anti-Hsp70 IgG indicated a better outcome in patients suffering from severe angina undergoing coronary artery bypass grafting (n=17; Vogt et al 2004). …”

Section: Introductionmentioning

confidence: 99%

Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome

Zhang

Zhou

et al. 2010

Cell Stress and Chaperones

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Although immune reactions against heat shock proteins have been implicated in the pathogenesis of atherosclerosis, conflicting associations between Hsp70, anti-Hsp70 antibody and coronary heart disease (CHD) have been reported. This study assessed whether there is a significant association between extracellular human Hsp70, anti-Hsp70 antibody and acute coronary syndrome (ACS) and stable angina (SA), and examined dynamic changes in Hsp70 and anti-Hsp70 antibody levels induced by acute myocardial infarction (AMI). Plasma Hsp70 and anti-Hsp70 antibody levels in 291 patients with ACS (179 AMI, 112 unstable angina), 126 patients with SA and 417 age and sex-matched healthy subjects, and in 40 patients after admission for AMI, and on day 2, 3, and 7 after the onset of AMI were determined using enzyme-linked immunosorbent assays. Hsp70 levels were significantly higher in ACS and SA and anti-Hsp70 antibody levels were only markedly lower in ACS than controls. After adjustment for traditional CHD risk factors, increasing levels of Hsp70 were significantly associated with an increased risk and severity of ACS (P for trend<0.001), whereas increasing levels of anti-Hsp70 antibody were associated with a decreased risk of ACS (P for trend= 0.0003). High levels of Hsp70 combined with low levels of anti-Hsp70 antibody had a joint effect on the risk of ACS (OR, 5.14, 95% CI, 3.00-8.79; P<0.0001). In patients with AMI, Hsp70 levels decreased rapidly from days 1-7 after onset, whereas anti-Hsp70 antibody levels increased in patients with AMI. These findings suggest that higher Hsp70 levels or lower anti-Hsp70 antibody levels are independently associated with a higher risk of ACS. Higher Hsp70 levels and lower anti-Hsp70 antibody levels combine to further increase this risk.

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Detection of anti-hsp70 immunoglobulin G antibodies indicates better outcome in coronary artery bypass grafting patients suffering from severe preoperative angina

Cited by 12 publications

References 22 publications

Different Profile of Antioxidative Capacity Results in Pulmonary Dysfunction and Amplified Inflammatory Response After CABG Surgery

Different Profile of Antioxidative Capacity Results in Pulmonary Dysfunction and Amplified Inflammatory Response After CABG Surgery

Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?

Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome

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